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Pyridine N-Oxides and Derivatives Thereof in Organocatalysis

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Heterocyclic N-Oxides

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 53))

Abstract

Pyridine N-oxides are a class of mild Lewis bases that can activate certain kinds of Lewis acidic parts of molecules and hence increase reactivity of its nucleophilic part towards various reactions with electrophiles. This review aims to summarize the applications of various non-chiral and chiral pyridine N-oxides in catalysis of a variety of reactions. In addition, the applications of these reactions in syntheses of natural and bioactive compounds are mentioned as well.

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Notes

  1. 1.

    Trichlorosilyl enolates of aldehydes and ketones as the reagents of the first choice were found not reactive enough for addition to ketones.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Science, Charles University, Albertov 6, 128 43, Praha 2, Czech Republic

    Petr Koukal, Jan Ulč, David Nečas & Martin Kotora

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  1. Petr Koukal
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  2. Jan Ulč
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Correspondence to Martin Kotora .

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  1. University of Texas at San Antonio , San Antonio, Texas, USA

    Oleg V. Larionov

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Koukal, P., Ulč, J., Nečas, D., Kotora, M. (2017). Pyridine N-Oxides and Derivatives Thereof in Organocatalysis. In: Larionov, O. (eds) Heterocyclic N-Oxides. Topics in Heterocyclic Chemistry, vol 53. Springer, Cham. https://doi.org/10.1007/7081_2017_3

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