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Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles

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Peptidomimetics II

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 49))

Abstract

Iminium ion chemistry represents a versatile transformation capable of introducing structurally diverse constraints into peptide backbones. The compatibility of iminium ion chemistry with traditional solid-phase peptide synthesis methods enables the introduction of constraints without requiring solution-phase synthesis. This chapter describes the introduction of constrained molecular scaffolds composed of single, fused, and bridged heterocycles into peptide backbones.

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Acknowledgment

This work was supported by the Department of Chemistry and Biochemistry, University of Notre Dame as well as the projects P207/12/0473 from Czech Science Foundation (GACR) and CZ.1.07/2.3.00/30.0060 and 1.07/2.3.00/30.0004 from the European Social Fund.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Science, Institute of Molecular and Translational Medicine, Palacky University, 771 46, Olomouc, Czech Republic

    Agustina La-Venia, Pilar Ventosa-Andrés & Viktor Krchňák

  2. Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Center, Notre Dame, IN, 46556, USA

    Viktor Krchňák

Authors
  1. Agustina La-Venia
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  2. Pilar Ventosa-Andrés
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  3. Viktor Krchňák
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Corresponding author

Correspondence to Viktor Krchňák .

Editor information

Editors and Affiliations

  1. Départemente de Chimie, Université de Montréal Départemente de Chimie, MONTREAL, Québec, Canada

    William Lubell

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La-Venia, A., Ventosa-Andrés, P., Krchňák, V. (2015). Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles. In: Lubell, W. (eds) Peptidomimetics II. Topics in Heterocyclic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/7081_2015_194

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