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Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity

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Bioinorganic Chemistry

Part of the book series: Structure and Bonding ((STRUCTURE,volume 70))

Abstract

Current interest in the biological chemistry of phosphines and their metal complexes ranges from the widespread application of PH3 as a fumigant, to the clinical use of a Au(I)PEt3 complex as an anti-arthritic drug. Metal phosphine complexes also offer potential as heart-imaging agents and anti-cancer drugs. Data on cytotoxicity and anticancer activity are surveyed in detail with particular emphasis on diphosphines and their copper, silver and gold complexes. Chemistry of likely relevance to pharmacology is discussed: especially redox reactions (disulphide reduction, oxygen abstraction), radical reactions and metal binding. Much phosphine chemistry of relevance to biology has yet to be explored.

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  1. Department of Chemistry, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK

    Susan J. Berners-Price & Peter J. Sadler

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Berners-Price, S.J., Sadler, P.J. (1988). Phosphines and metal phosphine complexes: Relationship of chemistry to anticancer and other biological activity. In: Bioinorganic Chemistry. Structure and Bonding, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-50130-4_2

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