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Pharmacological Modulation of the Heat Shock Response

  • Chapter
Molecular Chaperones in Health and Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 172))

Abstract

Life presents a continuous series of stresses. Increasing the adaptation capacity of the organism is a long-term survival factor of various organisms and has become an attractive field of intensive therapeutic research. Induction of the heat shock response promotes survival after a wide variety of environmental stresses. Preclinical studies have proven that physiological and pharmacological chaperone inducers and co-inducers are an efficient therapeutic approach in different acute and chronic diseases. In this chapter, we summarize current knowledge of the current state of chaperone modulation and give a comprehensive list of the main drug candidates.

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  1. Department of Medical Chemistry, Semmelweis University, P.O. Box 260, 1444, Budapest, Hungary

    C. Sőti & P. Csermely

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  1. C. Sőti
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  2. P. Csermely
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Correspondence to P. Csermely .

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  1. Freiburg i.

    K. Starke

  2. Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Matthias Gaestel (Professor) (Professor)

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© 2006 Springer-Verlag Berlin Heidelberg

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Sőti, C., Csermely, P. (2006). Pharmacological Modulation of the Heat Shock Response. In: Starke, K., Gaestel, M. (eds) Molecular Chaperones in Health and Disease. Handbook of Experimental Pharmacology, vol 172. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29717-0_17

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