Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 172)
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Table of contents (17 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Chaperones in Health and Disease
Editors: K. Starke, Matthias Gaestel
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/3-540-29717-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2006
Hardcover ISBN: 978-3-540-25875-9Published: 27 September 2005
Softcover ISBN: 978-3-642-06524-8Published: 12 February 2010
eBook ISBN: 978-3-540-29717-8Published: 29 December 2005
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: X, 442
Number of Illustrations: 29 b/w illustrations, 5 illustrations in colour
Topics: Biochemistry, general, Pharmacology/Toxicology, Medical Biochemistry, Cell Biology