Definition
Cardiomyopathies are diseases of heart muscle that are associated with cardiac dysfunction. These disorders are classified on the basis of morphology and function into four categories: hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia and restrictive cardiomyopathy. Dilated cardiomyopathy (DCM) is characterized by dilation and contractile dysfunction of the left (± right) ventricles. DCM may result from a variety of conditions that impair cardiomyocyte function or cause cardiomyocyte injury or loss, including myocardial ischaemia, infection, inflammation, increased pressure or volume load, and toxic agents. In approximately 50% cases, an underlying cause is unable to be identified and DCM is termed idiopathic. Over the past decade, it has been recognized that genetic factors are also an important cause of DCM. When DCM is caused by an inherited gene defect in families, it is known as familial DCM. Studies to date have...
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Acknowledgements
Dr Fatkin is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation.
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© 2005 Springer-Verlag
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Fatkin, D. (2005). Familial Dilated Cardiomyopathy. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_2080
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DOI: https://doi.org/10.1007/3-540-29623-9_2080
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
Online ISBN: 978-3-540-29623-2
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