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Funktionelle Genomik und Proteomik

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Pädiatrische Hämatologie und Onkologie

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Zusammenfassung

»Für die Entstehung der Tumorzelle sind offenbar Vorgänge an bestimmten Strukturen im Zellplasma und Kern entscheidend« (Domagk 1956). Trotz seines Alters hat dieser Satz auch heute noch uneingeschränkte Aktualität. Die Eigenschaften von Zellen und Geweben werden im Wesentlichen durch das Zusammenspiel der in diesen Zellen und Geweben vorliegenden Proteine bestimmt. Unterschiede in der Zusammensetzung und im Zustand dieser Proteine zwischen Tumorzellen und den entsprechenden normalen Zellen sind nach unserer heutigen Vorstellung für Tumorentstehung und -progression entscheidend verantwortlich. Diese Parameter werden durch genetische und epigenetische Mechanismen gesteuert. Die Aufklärung solcher Mechanismen — keineswegs beschränkt auf Fragen der Krebsforschung — ist Gegenstand der relativ neuen Forschungsgebiete der funktionellen Genomik und Proteomik.

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Author information

Authors and Affiliations

  1. Kinderklinik und Poliklinik der TU München Kinderklinik Schwabing, Kölner Platz 1, 80804, München

    Prof. Dr. Stefan Burdach

  2. Zentrum für Kinderheilkunde, Universitätsklinik und Poliklinik für Kinder- und Jugendmedizin Hämatologie/Onkologie, Ernst-Grube-Str. 40, 06097, Halle

    Dr. Martin S. Staege

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  1. Prof. Dr. Stefan Burdach
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  2. Dr. Martin S. Staege
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Editors and Affiliations

  1. Forschungsinstitut für krebskranke Kinder, St. Anna Kinderspital, Kinderspitalgasse 6, 1090, Wien, Österreich

    Helmut Gadner

  2. Klinik für Allgemeine Pädiatrie und Knochenmarktransplantation, Charité Campus Virchow-Klinikum Otto-Heubner-Centrum für Kinder- und Jugendmedizin, Augustenburger Platz 1, 13353, Berlin

    Gerhard Gaedicke

  3. Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Freiburg, Mathildenstr. 1, 79106, Freiburg

    Charlotte Niemeyer

  4. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129, Münster

    Jörg Ritter

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© 2006 Springer Medizin Verlag Heidelberg

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Burdach, S., Staege, M.S. (2006). Funktionelle Genomik und Proteomik. In: Gadner, H., Gaedicke, G., Niemeyer, C., Ritter, J. (eds) Pädiatrische Hämatologie und Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29036-2_49

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  • DOI: https://doi.org/10.1007/3-540-29036-2_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-03702-6

  • Online ISBN: 978-3-540-29036-0

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