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Quasispecies in Time-Dependent Environments

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Book cover Quasispecies: Concept and Implications for Virology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 299))

Abstract

In recent years, quasispecies theory in time-dependent (that is, dynamically changing) environments has made dramatic progress. Several groups have addressed questions such as how the time scale of the changes affect viral adaptation and quasispecies formation, how environmental changes affect the optimal mutation rate, or how virus and host co-evolve. Here, we review these recent developments, and give a nonmathematical introduction to the most important concepts and results of quasispecies theory in time-dependent environments. We also compare the theoretical results with results from evolution experiments that expose viruses to successive regimes of replication in two or more different hosts.

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Author information

Authors and Affiliations

  1. Section of Integrative Biology and Center for Computational Biology and Bioinformatics, University of Texas, Austin, TX, 78712, USA

    C. O. Wilke

  2. Digital Life Laboratory, California Institute of Technology, MC 136-93, Pasadena, CA, 91125, USA

    R. Forster

  3. Department of Medical Microbiology and Immunology, Medical University Ohio, 3055 Arlington Ave., Toledo, OH, 43616, USA

    I. S. Novella

Authors
  1. C. O. Wilke
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  2. R. Forster
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  3. I. S. Novella
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Editor information

Editors and Affiliations

  1. Centro de BiologÍa Molecular “Servero Ochoa” (CSIC-UAM), Universidad Autónoma de Madrid, 28049, Cantoblanco, Madrid, Spain

    Esteban Domingo

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© 2006 Springer-Verlag Berlin Heidelberg

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Wilke, C.O., Forster, R., Novella, I.S. (2006). Quasispecies in Time-Dependent Environments. In: Domingo, E. (eds) Quasispecies: Concept and Implications for Virology. Current Topics in Microbiology and Immunology, vol 299. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26397-7_2

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