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Dopamine changes in a rat model of intracerebral hemorrhage

  • Conference paper
Brain Edema XIII

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 96))

Summary

Recent case reports suggest that dopamine (DA) replacement may reduce behavioral deficits resulting from hemorrhages along the nigrostriatal tract. In the rat model of intracerebral hemorrhage (ICH), behavioral deficits are first evident on day 1, with return to near control levels by day 28. The current study was conducted to determine if striatal dopamine alterations are correlated with behavioral deficits. Gamma-aminobutyric acid (GABA) levels were measured to determine selectivity. Striatal DA, DA metabolites, and GABA were determined at days 1, 3, 7, and 28 after ICH by highpressure liquid chromatography with electrochemical detection. ICH resulted in significant increases above control in DA contralateral to the lesion (177 to 361% above control, days 1 to 28). There were also significant, but much less marked changes in GABA. In the ipsilateral striatum, significant DA increases also occurred (∼200% at day 3 and ∼275% day 28), while GABA alterations were not significant. These results indicate that the striatal DA system is selectively altered after ICH. Further studies will be needed to determine if regional dopamine alterations occur relative to the location of the hematoma.

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Author information

Authors and Affiliations

  1. Crosby Neurosurgical Laboratories, University of Michigan Medical School, R5550 Kresge I Bldg., 200 Zina Pitcher Place, Ann Arbor, MI, 48109-0532, USA

    G. Xi

  2. Department of Environmental Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    J. R. Cannon & R. J. Richardson

  3. Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA

    J. R. Cannon, T. Nakamura, R. F. Keep, Y. Hua & G. Xi

  4. Department of Physiology, University of Michigan Medical School, Ann Arbor, MI, USA

    R. F. Keep

Authors
  1. J. R. Cannon
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  2. T. Nakamura
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  3. R. F. Keep
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  4. R. J. Richardson
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  5. Y. Hua
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  6. G. Xi
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA

    Julian T. Hoff , Richard F. Keep , Guohua Xi  & Ya Hua , ,  & 

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© 2006 Springer-Verlag

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Cannon, J.R., Nakamura, T., Keep, R.F., Richardson, R.J., Hua, Y., Xi, G. (2006). Dopamine changes in a rat model of intracerebral hemorrhage. In: Hoff, J.T., Keep, R.F., Xi, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_48

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  • DOI: https://doi.org/10.1007/3-211-30714-1_48

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-30712-0

  • Online ISBN: 978-3-211-30714-4

  • eBook Packages: MedicineMedicine (R0)

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