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Substance Use Disorders pp 373–393Cite as

Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 258))

Abstract

Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices. Thus, an understanding of the molecular mechanisms underlying nicotine pharmacology and dependence is required to ascertain novel approaches to treat drug dependence. In this chapter, we review the field’s current understanding of nicotine’s actions in the brain, the neurocircuitry underlying drug dependence, factors that modulate the function of nicotinic acetylcholine receptors, and the role of specific genes in mitigating the vulnerability to develop nicotine dependence. In addition to nicotine’s direct actions in the brain, other constituents in nicotine and tobacco products have also been found to alter drug use, and thus, evidence is provided to highlight this issue. Finally, currently available pharmacotherapeutic strategies are discussed, along with an outlook for future therapeutic directions to achieve to the goal of long-term nicotine cessation.

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Authors and Affiliations

  1. Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA

    Christie D. Fowler

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA

    Jill R. Turner

  3. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA

    M. Imad Damaj

  4. Translational Research Initiative for Pain and Neuropathy at VCU, Richmond, VA, USA

    M. Imad Damaj

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  1. Christie D. Fowler
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  2. Jill R. Turner
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  3. M. Imad Damaj
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Correspondence to M. Imad Damaj .

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  1. Wake Forest School of Medicine, Winston-Salem, NC, USA

    Michael A. Nader

  2. Addiction Institute of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Yasmin L. Hurd

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Fowler, C.D., Turner, J.R., Imad Damaj, M. (2019). Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. In: Nader, M., Hurd, Y. (eds) Substance Use Disorders. Handbook of Experimental Pharmacology, vol 258. Springer, Cham. https://doi.org/10.1007/164_2019_252

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