Abstract
The actin cytoskeleton is a crucial part of the eukaryotic cell. Viruses depend on host cells for their replication, and, as a result, many have developed ways of manipulating the actin network to promote their spread. This chapter reviews the various ways in which viruses utilize the actin cytoskeleton at discrete steps in their life cycle, from entry into the host cell, replication, and assembly of new progeny to virus release. Various actin inhibitors that function in different ways to affect proper actin dynamics can be used to parse the role of actin at these steps.
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Acosta EG, Castilla V, Damonte EB (2011) Infectious dengue-1 virus entry into mosquito C6/36 cells. Virus Res 160:173–179
Aggarwal A, Iemma TL, Shih I, Newsome TP, McAllery S, Cunningham AL, Turville SG (2012) Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells. PLoS Pathog 8, e1002762
Akhtar J, Shukla D (2009) Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry. FEBS J 276:7228–7236
Akula SM, Naranatt PP, Walia NS, Wang FZ, Fegley B, Chandran B (2003) Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis. J Virol 77:7978–7990
Alonso C, Galindo I, Cuesta-Geijo MA, Cabezas M, Hernaez B, Munoz-Moreno R (2013) African swine fever virus-cell interactions: from virus entry to cell survival. Virus Res 173:42–57
Amyere M, Payrastre B, Krause U, Van Der Smissen P, Veithen A, Courtoy PJ (2000) Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C. Mol Biol Cell 11:3453–3467
Arakawa Y, Cordeiro JV, Schleich S, Newsome TP, Way M (2007a) The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host Microbe 1:227–240
Arakawa Y, Cordeiro JV, Way M (2007b) F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during vaccinia virus infection. Cell Host Microbe 1:213–226
Araki N, Johnson MT, Swanson JA (1996) A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J Cell Biol 135:1249–1260
Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805–809
Arhel N, Genovesio A, Kim KA, Miko S, Perret E, Olivo-Marin JC, Shorte S, Charneau P (2006) Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nat Methods 3:817–824
Aspenstrom P, Fransson A, Saras J (2004) Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J 377:327–337
Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y (2014) Influenza A virus uses the aggresome processing machinery for host cell entry. Science 346:473–477
Barrero-Villar M, Cabrero JR, Gordon-Alonso M, Barroso-Gonzalez J, Alvarez-Losada S, Munoz-Fernandez MA, Sanchez-Madrid F, Valenzuela-Fernandez A (2009) Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J Cell Sci 122:103–113
Bastiani M, Parton RG (2010) Caveolae at a glance. J Cell Sci 123:3831–3836
Bear JE, Krause M, Gertler FB (2001) Regulating cellular actin assembly. Curr Opin Cell Biol 13:158–166
Berg JS, Powell BC, Cheney RE (2001) A millennial myosin census. Mol Biol Cell 12:780–794
Berghall H, Wallen C, Hyypia T, Vainionpaa R (2004) Role of cytoskeleton components in measles virus replication. Arch Virol 149:891–901
Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW (2014) Nuclear herpesvirus capsid motility is not dependent on F-actin. MBio 5:e01909–e01914
Boucrot E, Saffarian S, Massol R, Kirchhausen T, Ehrlich M (2006) Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res 312:4036–4048
Braet F, De Zanger R, Jans D, Spector I, Wisse E (1996) Microfilament-disrupting agent latrunculin A induces and increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B. Hepatology 24:627–635
Brandenburg B, Lee LY, Lakadamyali M, Rust MJ, Zhuang X, Hogle JM (2007) Imaging poliovirus entry in live cells. PLoS Biol 5, e183
Bravo-Cordero JJ, Magalhaes MA, Eddy RJ, Hodgson L, Condeelis J (2013) Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol 14:405–415
Burke E, Mahoney NM, Almo SC, Barik S (2000) Profilin is required for optimal actin-dependent transcription of respiratory syncytial virus genome RNA. J Virol 74:669–675
Carlier MF, Pernier J, Montaville P, Shekhar S, Kuhn S; Cytoskeleton Dynamics and Motility Group (2015) Control of polarized assembly of actin filaments in cell motility. Cell Mol Life Sci 72:3051–3067
Carlson LA, de Marco A, Oberwinkler H, Habermann A, Briggs JA, Krausslich HG, Grunewald K (2010) Cryo electron tomography of native HIV-1 budding sites. PLoS Pathog 6, e1001173
Charlton CA, Volkman LE (1993) Penetration of Autographa californica nuclear polyhedrosis virus nucleocapsids into IPLB Sf 21 cells induces actin cable formation. Virology 197:245–254
Chhabra ES, Higgs HN (2007) The many faces of actin: matching assembly factors with cellular structures. Nat Cell Biol 9:1110–1121
Cibulka J, Fraiberk M, Forstova J (2012) Nuclear actin and lamins in viral infections. Viruses 4:325–347
Clement C, Tiwari V, Scanlan PM, Valyi-Nagy T, Yue BY, Shukla D (2006) A novel role for phagocytosis-like uptake in herpes simplex virus entry. J Cell Biol 174:1009–1021
Conti MA, Adelstein RS (2008) Nonmuscle myosin II moves in new directions. J Cell Sci 121:11–18
Cooper JA (1987) Effects of cytochalasin and phalloidin on actin. J Cell Biol 105:1473–1478
Cordeiro JV, Guerra S, Arakawa Y, Dodding MP, Esteban M, Way M (2009) F11-mediated inhibition of RhoA signalling enhances the spread of vaccinia virus in vitro and in vivo in an intranasal mouse model of infection. PLoS One 4, e8506
Coue M, Brenner SL, Spector I, Korn ED (1987) Inhibition of actin polymerization by latrunculin A. FEBS Lett 213:316–318
Cramer LP (1999) Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr Biol 9:1095–1105
Cudmore S, Cossart P, Griffiths G, Way M (1995) Actin-based motility of vaccinia virus. Nature 378:636–638
Cudmore S, Reckmann I, Griffiths G, Way M (1996) Vaccinia virus: a model system for actin-membrane interactions. J Cell Sci 109(Pt 7):1739–1747
Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP (2009) Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog 5, e1000394
Dietzel E, Kolesnikova L, Maisner A (2013) Actin filaments disruption and stabilization affect measles virus maturation by different mechanisms. Virol J 10:249
Disanza A, Steffen A, Hertzog M, Frittoli E, Rottner K, Scita G (2005) Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement. Cell Mol Life Sci 62:955–970
Dixit R, Tiwari V, Shukla D (2008) Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread. Neurosci Lett 440:113–118
Doceul V, Hollinshead M, van der Linden L, Smith GL (2010) Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science 327:873–876
Dolnik O, Kolesnikova L, Welsch S, Strecker T, Schudt G, Becker S (2014) Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells. PLoS Pathog 10, e1004463
Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T (2004) Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 118:591–605
Fackler OT, Kienzle N, Kremmer E, Boese A, Schramm B, Klimkait T, Kucherer C, Mueller-Lantzsch N (1997) Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization. Eur J Biochem 247:843–851
Favoreel HW, Enquist LW, Feierbach B (2007) Actin and Rho GTPases in herpesvirus biology. Trends Microbiol 15:426–433
Feierbach B, Piccinotti S, Bisher M, Denk W, Enquist LW (2006) Alpha-herpesvirus infection induces the formation of nuclear actin filaments. PLoS Pathog 2, e85
Forzan M, Marsh M, Roy P (2007) Bluetongue virus entry into cells. J Virol 81:4819–4827
Frischknecht F, Cudmore S, Moreau V, Reckmann I, Rottger S, Way M (1999) Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella. Curr Biol 9:89–92
Fuchsova B, Serebryannyy LA, de Lanerolle P (2015) Nuclear actin and myosins in adenovirus infection. Exp Cell Res 338:170–182
Galindo I, Cuesta-Geijo MA, Hlavova K, Munoz-Moreno R, Barrado-Gil L, Dominguez J, Alonso C (2015) African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis. Virus Res 200:45–55
Gaudin R, de Alencar BC, Arhel N, Benaroch P (2013) HIV trafficking in host cells: motors wanted! Trends Cell Biol 23:652–662
Giuffre RM, Tovell DR, Kay CM, Tyrrell DL (1982) Evidence for an interaction between the membrane protein of a paramyxovirus and actin. J Virol 42:963–968
Goley ED, Ohkawa T, Mancuso J, Woodruff JB, D'Alessio JA, Cande WZ, Volkman LE, Welch MD (2006) Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein. Science 314:464–467
Gouin E, Welch MD, Cossart P (2005) Actin-based motility of intracellular pathogens. Curr Opin Microbiol 8:35–45
Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, Chenouard N, de Chaumont F, Martino A, Enninga J, Olivo-Marin JC, Mannel D, Zurzolo C (2009) Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 11:328–336
Greene W, Gao SJ (2009) Actin dynamics regulate multiple endosomal steps during Kaposi's sarcoma-associated herpesvirus entry and trafficking in endothelial cells. PLoS Pathog 5, e1000512
Gudheti MV, Curthoys NM, Gould TJ, Kim D, Gunewardene MS, Gabor KA, Gosse JA, Kim CH, Zimmerberg J, Hess ST (2013) Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin. Biophys J 104:2182–2192
Handa Y, Durkin CH, Dodding MP, Way M (2013) Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling. Cell Host Microbe 14:51–62
Hao X, Shang X, Wu J, Shan Y, Cai M, Jiang J, Huang Z, Tang Z, Wang H (2011) Single-particle tracking of hepatitis B virus-like vesicle entry into cells. Small 7:1212–1218
Harries PA, Park JW, Sasaki N, Ballard KD, Maule AJ, Nelson RS (2009) Differing requirements for actin and myosin by plant viruses for sustained intercellular movement. Proc Natl Acad Sci U S A 106:17594–17599
Hartman MA, Spudich JA (2012) The myosin superfamily at a glance. J Cell Sci 125:1627–1632
Hassan SS, Roy P (1999) Expression and functional characterization of bluetongue virus VP2 protein: role in cell entry. J Virol 73:9832–9842
Hasson T (2003) Myosin VI: two distinct roles in endocytosis. J Cell Sci 116:3453–3461
Hernaez B, Alonso C (2010) Dynamin- and clathrin-dependent endocytosis in African swine fever virus entry. J Virol 84:2100–2109
Hofmann W, Reichart B, Ewald A, Muller E, Schmitt I, Stauber RH, Lottspeich F, Jockusch BM, Scheer U, Hauber J, Dabauvalle MC (2001) Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol 152:895–910
Hollinshead M, Rodger G, Van Eijl H, Law M, Hollinshead R, Vaux DJ, Smith GL (2001) Vaccinia virus utilizes microtubules for movement to the cell surface. J Cell Biol 154:389–402
Horsington J, Lynn H, Turnbull L, Cheng D, Braet F, Diefenbach RJ, Whitchurch CB, Karupiah G, Newsome TP (2013) A36-dependent actin filament nucleation promotes release of vaccinia virus. PLoS Pathog 9, e1003239
Humphries AC, Way M (2013) The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread. Nat Rev Microbiol 11:551–560
Humphries AC, Dodding MP, Barry DJ, Collinson LM, Durkin CH, Way M (2012) Clathrin potentiates vaccinia-induced actin polymerization to facilitate viral spread. Cell Host Microbe 12:346–359
Humphries AC, Donnelly SK, Way M (2014) Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation. J Cell Sci 127:673–685
Iyengar S, Hildreth JE, Schwartz DH (1998) Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells. J Virol 72:5251–5255
Jimenez-Baranda S, Gomez-Mouton C, Rojas A, Martinez-Prats L, Mira E, Ana Lacalle R, Valencia A, Dimitrov DS, Viola A, Delgado R, Martinez AC, Manes S (2007) Filamin-A regulates actin-dependent clustering of HIV receptors. Nat Cell Biol 9:838–846
Jouvenet N, Windsor M, Rietdorf J, Hawes P, Monaghan P, Way M, Wileman T (2006) African swine fever virus induces filopodia-like projections at the plasma membrane. Cell Microbiol 8:1803–1811
Kadiu I, Gendelman HE (2011) Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. J Neuroimmune Pharmacol 6:658–675
Kalia M, Khasa R, Sharma M, Nain M, Vrati S (2013) Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism. J Virol 87:148–162
Kalin S, Amstutz B, Gastaldelli M, Wolfrum N, Boucke K, Havenga M, DiGennaro F, Liska N, Hemmi S, Greber UF (2010) Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J Virol 84:5336–5350
Kallewaard NL, Bowen AL, Crowe JE Jr (2005) Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus. Virology 331:73–81
Khaitlina SY (2014) Intracellular transport based on actin polymerization. Biochemistry (Mosc) 79:917–927
Kimura T, Hashimoto I, Yamamoto A, Nishikawa M, Fujisawa JI (2000) Rev-dependent association of the intron-containing HIV-1 gag mRNA with the nuclear actin bundles and the inhibition of its nucleocytoplasmic transport by latrunculin-B. Genes Cells 5:289–307
Koga R, Sugita Y, Noda T, Yanagi Y, Ohno S (2015) Actin-modulating protein cofilin is involved in the formation of measles virus ribonucleoprotein complex at the perinuclear region. J Virol 89:10524–10531
Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S (2010) Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol 188:547–563
Kumakura M, Kawaguchi A, Nagata K (2015) Actin-myosin network is required for proper assembly of influenza virus particles. Virology 476:141–150
Lakadamyali M, Rust MJ, Babcock HP, Zhuang X (2003) Visualizing infection of individual influenza viruses. Proc Natl Acad Sci U S A 100:9280–9285
Lanier LM, Volkman LE (1998) Actin binding and nucleation by Autographa california M nucleopolyhedrovirus. Virology 243:167–177
Lehmann MJ, Sherer NM, Marks CB, Pypaert M, Mothes W (2005) Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol 170:317–325
Lehmann M, Nikolic DS, Piguet V (2011) How HIV-1 takes advantage of the cytoskeleton during replication and cell-to-cell transmission. Viruses 3:1757–1776
Leite F, Way M (2015) The role of signalling and the cytoskeleton during Vaccinia Virus egress. Virus Res 209:87–99
Lim JP, Gleeson PA (2011) Macropinocytosis: an endocytic pathway for internalising large gulps. Immunol Cell Biol 89:836–843
Liu Y, Belkina NV, Shaw S (2009) HIV infection of T cells: actin-in and actin-out. Sci Signal. 2:pe23
Marek M, Merten OW, Galibert L, Vlak JM, van Oers MM (2011) Baculovirus VP80 protein and the F-actin cytoskeleton interact and connect the viral replication factory with the nuclear periphery. J Virol 85:5350–5362
Mattila PK, Lappalainen P (2008) Filopodia: molecular architecture and cellular functions. Nat Rev Mol Cell Biol 9:446–454
Mayor S, Pagano RE (2007) Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol 8:603–612
McMahon HT, Boucrot E (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 12:517–533
McNiven MA, Kim L, Krueger EW, Orth JD, Cao H, Wong TW (2000) Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J Cell Biol 151:187–198
Meier O, Greber UF (2004) Adenovirus endocytosis. J Gene Med 6(Suppl 1):S152–S163
Meier O, Boucke K, Hammer SV, Keller S, Stidwill RP, Hemmi S, Greber UF (2002) Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J Cell Biol 158:1119–1131
Mercer J, Helenius A (2008) Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 320:531–535
Mercer J, Helenius A (2009) Virus entry by macropinocytosis. Nat Cell Biol 11:510–520
Merrifield CJ, Moss SE, Ballestrem C, Imhof BA, Giese G, Wunderlich I, Almers W (1999) Endocytic vesicles move at the tips of actin tails in cultured mast cells. Nat Cell Biol 1:72–74
Merrifield CJ, Feldman ME, Wan L, Almers W (2002) Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits. Nat Cell Biol 4:691–698
Mitchison T, Kirschner M (1988) Cytoskeletal dynamics and nerve growth. Neuron 1:761–772
Moreau V, Frischknecht F, Reckmann I, Vincentelli R, Rabut G, Stewart D, Way M (2000) A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nat Cell Biol 2:441–448
Naghavi MH, Goff SP (2007) Retroviral proteins that interact with the host cell cytoskeleton. Curr Opin Immunol 19:402–407
Nanbo A, Imai M, Watanabe S, Noda T, Takahashi K, Neumann G, Halfmann P, Kawaoka Y (2010) Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog 6, e1001121
Newsome TP, Scaplehorn N, Way M (2004) SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus. Science 306:124–129
Newsome TP, Weisswange I, Frischknecht F, Way M (2006) Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cell Microbiol 8:233–241
Oh MJ, Akhtar J, Desai P, Shukla D (2010) A role for heparan sulfate in viral surfing. Biochem Biophys Res Commun 391:176–181
Ohkawa T, Volkman LE (1999) Nuclear F-actin is required for AcMNPV nucleocapsid morphogenesis. Virology 264:1–4
Ohkawa T, Rowe AR, Volkman LE (2002) Identification of six Autographa californica multicapsid nucleopolyhedrovirus early genes that mediate nuclear localization of G-actin. J Virol 76:12281–12289
Ohkawa T, Volkman LE, Welch MD (2010) Actin-based motility drives baculovirus transit to the nucleus and cell surface. J Cell Biol 190:187–195
Pelkmans L, Puntener D, Helenius A (2002) Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae. Science 296:535–539
Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112:453–465
Pollard TD, Blanchoin L, Mullins RD (2000) Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 29:545–576
Praefcke GJ, McMahon HT (2004) The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 5:133–147
Raftopoulou M, Hall A (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265:23–32
Raghu H, Sharma-Walia N, Veettil MV, Sadagopan S, Chandran B (2009) Kaposi’s sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. J Virol 83:4895–4911
Reeves PM, Bommarius B, Lebeis S, McNulty S, Christensen J, Swimm A, Chahroudi A, Chavan R, Feinberg MB, Veach D, Bornmann W, Sherman M, Kalman D (2005) Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nat Med 11:731–739
Rey O, Canon J, Krogstad P (1996) HIV-1 Gag protein associates with F-actin present in microfilaments. Virology 220:530–534
Rietdorf J, Ploubidou A, Reckmann I, Holmstrom A, Frischknecht F, Zettl M, Zimmermann T, Way M (2001) Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus. Nat Cell Biol 3:992–1000
Roberts KL, Manicassamy B, Lamb RA (2015) Influenza A virus uses intercellular connections to spread to neighboring cells. J Virol 89:1537–1549
Rohrmann GF, Erlandson MA, Theilmann DA (2013) The genome of a baculovirus isolated from Hemileuca sp. encodes a serpin ortholog. Virus Genes 47:357–364
Rust MJ, Lakadamyali M, Zhang F, Zhuang X (2004) Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat Struct Mol Biol 11:567–573
Saeed MF, Kolokoltsov AA, Albrecht T, Davey RA (2010) Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. PLoS Pathog 6, e1001110
Saffarian S, Cocucci E, Kirchhausen T (2009) Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol 7, e1000191
Sanchez EG, Quintas A, Perez-Nunez D, Nogal M, Barroso S, Carrascosa AL, Revilla Y (2012) African swine fever virus uses macropinocytosis to enter host cells. PLoS Pathog 8, e1002754
Schelhaas M, Ewers H, Rajamaki ML, Day PM, Schiller JT, Helenius A (2008) Human papillomavirus type 16 entry: retrograde cell surface transport along actin-rich protrusions. PLoS Pathog 4, e1000148
Schelhaas M, Shah B, Holzer M, Blattmann P, Kuhling L, Day PM, Schiller JT, Helenius A (2012) Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis. PLoS Pathog 8, e1002657
Schmidt FI, Mercer J (2012) Vaccinia virus egress: actin OUT with clathrin. Cell Host Microbe 12:263–265
Schmidt FI, Bleck CK, Helenius A, Mercer J (2011) Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture. EMBO J 30:3647–3661
Schudt G, Kolesnikova L, Dolnik O, Sodeik B, Becker S (2013) Live-cell imaging of Marburg virus-infected cells uncovers actin-dependent transport of nucleocapsids over long distances. Proc Natl Acad Sci U S A 110:14402–14407
Sherer NM, Lehmann MJ, Jimenez-Soto LF, Horensavitz C, Pypaert M, Mothes W (2007) Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol 9:310–315
Simpson-Holley M, Ellis D, Fisher D, Elton D, McCauley J, Digard P (2002) A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions. Virology 301:212–225
Snapper SB, Takeshima F, Anton I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW (2001) N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol 3:897–904
Spector I, Shochet NR, Kashman Y, Groweiss A (1983) Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science 219:493–495
Spudich JA (1989) In pursuit of myosin function. Cell Regul 1:1–11
Stevens JM, Galyov EE, Stevens MP (2006) Actin-dependent movement of bacterial pathogens. Nat Rev Microbiol 4:91–101
Stradal TE, Rottner K, Disanza A, Confalonieri S, Innocenti M, Scita G (2004) Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol 14:303–311
Sun X, Whittaker GR (2007) Role of the actin cytoskeleton during influenza virus internalization into polarized epithelial cells. Cell Microbiol 9:1672–1682
Swanson JA, Watts C (1995) Macropinocytosis. Trends Cell Biol 5:424–428
Tahara M, Takeda M, Yanagi Y (2007) Altered interaction of the matrix protein with the cytoplasmic tail of hemagglutinin modulates measles virus growth by affecting virus assembly and cell-cell fusion. J Virol 81:6827–6836
Taunton J (2001) Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr Opin Cell Biol 13:85–91
Taylor MJ, Lampe M, Merrifield CJ (2012) A feedback loop between dynamin and actin recruitment during clathrin-mediated endocytosis. PLoS Biol 10, e1001302
Thomas A, Mariani-Floderer C, Lopez-Huertas MR, Gros N, Hamard-Peron E, Favard C, Ohlmann T, Alcami J, Muriaux D (2015) Involvement of the Rac1-IRSp53-Wave2-Arp2/3 signaling pathway in HIV-1 Gag particle release in CD4 T cells. J Virol 89:8162–8181
Valderrama F, Cordeiro JV, Schleich S, Frischknecht F, Way M (2006) Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311:377–381
van der Schaar HM, Rust MJ, Chen C, van der Ende-Metselaar H, Wilschut J, Zhuang X, Smit JM (2008) Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathog 4, e1000244
Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR (2009) Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol 10:778–790
Wakimoto H, Shimodo M, Satoh Y, Kitagawa Y, Takeuchi K, Gotoh B, Itoh M (2013) F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin. J Virol 87:1974–1984
Wang S, Huang X, Huang Y, Hao X, Xu H, Cai M, Wang H, Qin Q (2014) Entry of a novel marine DNA virus, Singapore grouper iridovirus, into host cells occurs via clathrin-mediated endocytosis and macropinocytosis in a pH-dependent manner. J Virol 88:13047–13063
Wang Y, Zhang Y, Han S, Hu X, Zhou Y, Mu J, Pei R, Wu C, Chen X (2015) Identification of a novel regulatory sequence of actin nucleation promoting factor encoded by Autographa californica multiple nucleopolyhedrovirus. J Biol Chem 290:9533–9541
Ward BM, Moss B (2001) Vaccinia virus intracellular movement is associated with microtubules and independent of actin tails. J Virol 75:11651–11663
Weisswange I, Newsome TP, Schleich S, Way M (2009) The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature 458:87–91
Welch MD, Mullins RD (2002) Cellular control of actin nucleation. Annu Rev Cell Dev Biol 18:247–288
Wild TF, Malvoisin E, Buckland R (1991) Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion. J Gen Virol 72(Pt 2):439–442
Xiang Y, Zheng K, Ju H, Wang S, Pei Y, Ding W, Chen Z, Wang Q, Qiu X, Zhong M, Zeng F, Ren Z, Qian C, Liu G, Kitazato K, Wang Y (2012) Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication. J Virol 86:8440–8451
Yarar D, Waterman-Storer CM, Schmid SL (2005) A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell 16:964–975
Yoder A, Yu D, Dong L, Iyer SR, Xu X, Kelly J, Liu J, Wang W, Vorster PJ, Agulto L, Stephany DA, Cooper JN, Marsh JW, Wu Y (2008) HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134:782–792
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Marzook, N.B., Newsome, T.P. (2016). Viruses That Exploit Actin-Based Motility for Their Replication and Spread. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_41
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DOI: https://doi.org/10.1007/164_2016_41
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