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Daunomycin-TFO Conjugates for Downregulation of Gene Expression

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Anthracycline Chemistry and Biology II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 283))

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Abstract

Daunomycin has shown interesting properties as a stabilizing agent for the antigene methodology.This approach consists of targeting a polypurine region of a given gene, with a triplex formingoligonucleotide (TFO), realizing a triple helix complex (triplex), with the aim of down-regulatinggene expression. This chapter describes the basic principles of the triplex approach, the chemistry underliningthe binding of daunomycin to oligonucleotides, and some results of gene-inhibition obtained with daunomycin-TFOconjugates with different targets.

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Author information

Authors and Affiliations

  1. ISOF-CNR, Via Gobetti 101, 40129, Bologna, Italy

    Massimo L. Capobianco

  2. Laboratory of Experimental Oncology, IOSI, Via Vela 6, 6500, Bellinzona, Switzerland

    Carlo V. Catapano

Authors
  1. Massimo L. Capobianco
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  2. Carlo V. Catapano
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Correspondence to Massimo L. Capobianco .

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Karsten Krohn

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© 2007 Springer-Verlag Berlin Heidelberg

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Capobianco, M.L., Catapano, C.V. (2007). Daunomycin-TFO Conjugates for Downregulation of Gene Expression. In: Krohn, K. (eds) Anthracycline Chemistry and Biology II. Topics in Current Chemistry, vol 283. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_2

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