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Solid-State Nanopores for Biomolecular Analysis and Detection

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Advances in Biochemical Engineering/Biotechnology

Abstract

Advances in nanopore technology and data processing have rendered DNA sequencing highly accessible, unlocking a new realm of biotechnological opportunities. Commercially available nanopores for DNA sequencing are of biological origin and have certain disadvantages such as having specific environmental requirements to retain functionality. Solid-state nanopores have received increased attention as modular systems with controllable characteristics that enable deployment in non-physiological milieu. Thus, we focus our review on summarizing recent innovations in the field of solid-state nanopores to envision the future of this technology for biomolecular analysis and detection. We begin by introducing the physical aspects of nanopore measurements ranging from interfacial interactions at pore and electrode surfaces to mass transport of analytes and data analysis of recorded signals. Then, developments in nanopore fabrication and post-processing techniques with the pros and cons of different methodologies are examined. Subsequently, progress to facilitate DNA sequencing using solid-state nanopores is described to assess how this platform is evolving to tackle the more complex challenge of protein sequencing. Beyond sequencing, we highlight the recent developments in biosensing of nucleic acids, proteins, and sugars and conclude with an outlook on the frontiers of nanopore technologies.

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Author notes

  1. Annina Stuber, Tilman Schlotter, and Julian Hengsteler contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zürich, Zürich, Switzerland

    Annina Stuber, Tilman Schlotter, Julian Hengsteler & Nako Nakatsuka

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  1. Annina Stuber
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  2. Tilman Schlotter
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Correspondence to Nako Nakatsuka .

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The authors acknowledge ETH Zurich for funding and Prof. Janos Vörös for helpful discussions.

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The authors declare no competing financial interest.

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Stuber, A., Schlotter, T., Hengsteler, J., Nakatsuka, N. (2023). Solid-State Nanopores for Biomolecular Analysis and Detection. In: Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2023_240

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