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Molecular Response to Osmotic Shock

  • Chapter
Systems Biology

Part of the book series: Cell Engineering ((CEEN,volume 5))

Abstract

The cellular responses of cultured mammalian cells and non-mammalian organisms to changes in osmolarity are discussed. A number of common themes including activation of protein kinase cascades can be observed in a diverse group of organisms. A combination of physiological and transcriptional studies has been performed to identify regulatory factors and proteins that play a causal role in the cellular responses to osmotic changes. These factors may serve as targets for cellular engineering strategies to improve the productivity of cultured mammalian cells, particularly in response to osmotic shock

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Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590

    Susan T. Sharfstein, Duan Shen, Thomas R. Kiehl & Rui Zhou

Authors
  1. Susan T. Sharfstein
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  2. Duan Shen
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  3. Thomas R. Kiehl
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  4. Rui Zhou
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Editor information

Editors and Affiliations

  1. University College Dublin, Ireland

    Mohamed Al-Rubeai

  2. Swiss Federal Institute of Technology, ETH Hoenggeerberg HCI Institute of Chemical and Bioengineering ICB, Zurich, Switzerland

    Martin Fussenegger

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© 2007 Springer

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Sharfstein, S.T., Shen, D., Kiehl, T.R., Zhou, R. (2007). Molecular Response to Osmotic Shock. In: Al-Rubeai, M., Fussenegger, M. (eds) Systems Biology. Cell Engineering, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5252-9_7

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