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THE ARTERIAL CHEMORECEPTORS pp 267–274Cite as

Gene Expression and Signaling Pathways by Extracellular Acidification

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Part of the book series: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY ((AEMB,volume 580))

Abstract

The respiratory response to extracellular acidosis by hypercapnia is mediated by central chemoreceptor neurons in the medulla oblongata [1]. There are actually two defined groups of respiratory neurons. The dorsal group of neurons is located in and near the nucleus of the tractus solitarius and their activity is regulated by changes in the arterial partial pressure of CO2 (Pco2), O2 (Po2) or H+. The ventral group is a long column of neurons that extends through the nucleus ambiguous and retroambiguous in the ventrolateral medulla. In addition to reacting to peripheral stimuli, the ventral neurons detect changes in the H+ and/or CO2 concentrations in the cerebrospinal fluid (CSF) and brain interstitial fluid [2]. The capacity to detect these changes is called central chemosensitivity.

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Author information

Authors and Affiliations

  1. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, japan

    NORIAKI SHIMOKAWA, MARINA LONDOÑO & NORIYUKI KOIBUCHI

Authors
  1. NORIAKI SHIMOKAWA
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  2. MARINA LONDOÑO
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  3. NORIYUKI KOIBUCHI
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Editor information

Editors and Affiliations

  1. International Buddhist University, Osaka, Japan

    Yoshiaki Hayashida

  2. University of Valladolid, Valladolid, Spain

    Constancio Gonzalez

  3. Tohoku University, Sendai, Japan

    Hisatake Kondo

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© 2006 Springer

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SHIMOKAWA, N., LONDOÑO, M., KOIBUCHI, N. (2006). Gene Expression and Signaling Pathways by Extracellular Acidification. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_42

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