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Biochemistry of Adrenomedullin

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Book cover Adrenomedullin in Cardiovascular Disease

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 19))

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References

  • Andreis, P.G., Mazzocchi, G., Rebuffat, P., Nussdorfer, G.G. (1997) Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide on rat zona glomerulosa cells. Life Sci., 60: 1693–1697.

    Article  PubMed  Google Scholar 

  • Bean, A.J., Zhang, X. and Hoekfelt, T. (1994) Peptide secretion: what do we know? FASEB Journal., 8: 630–638.

    PubMed  Google Scholar 

  • Bradbury, A.F., Smyth, D.G. (1991) Modification of the N-and C-termini of bioactive peptides. In: Fricker LD (ed) Peptide Biosynthesis and Processing. CRC Press, Boca Raton, FL,: pp. 231–250.

    Google Scholar 

  • Chun, T-H., Itoh, H., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Doi, K., Inoue, M., Masatsugu, K., Korenaga, R., Ando, J., Nakao, K. (1997) Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension, 29: 1296–1302.

    PubMed  Google Scholar 

  • Cooper, C.J.S., Willis, A.C., Clark, A., Turner, R.C., Sim, R.B. and Reid, K.B.M. (1987) Purification and characterization of a peptide from amyloidrich pancreases of type 2 diabetic patients. Proc. Natl. Acad. Sci. U.S.A., 8: 8628–8632.

    Google Scholar 

  • Eguchi, S., Hirata, Y, Iwasaki, H., Sato, K., Watanabe, T.X., Inui, T., Nakajima, K., Sakakibara, S., Marumo, F. (1994a) Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology, 135: 2454–2458.

    Article  PubMed  Google Scholar 

  • Eguchi, S., Hirata, Y., Kano, H., Sato, K., Watanabe, Y., Watanabe, TX., Nakajima, K., Sakakibara, S., Maruno, F. (1994b) Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett., 340: 226–230.

    Article  PubMed  Google Scholar 

  • Fink, J.S., Verhave, M., Kasper, S. Tsukada, T., Mandel, G. and Goodman, R.H. (1988) The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated Proc. Nati. Acad. Sci. USA., 85: 6662–6666.

    Google Scholar 

  • Imagawa, M., Chiu, R. and Karin M. (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell, 51: 251–260.

    Article  PubMed  Google Scholar 

  • Ishimitsu, T., Kojima, M., Kangawa, K., Hino, J., Matsuoka, H., Kitamura, K., Eto, T. and Matsuo, H. (1994) Genomic structure of human adrenomedullin gene. Biochem. Biophys. Res. Commun., 203: 631–639.

    Article  PubMed  Google Scholar 

  • Ishimitsu, T., Miyata, A., Matsuoka, H., Kangawa, K. (1998) Transcriptional regulation of human adrenomedullin gene in vascular endothelial cells. Biochem. Biophys. Res. Commun., 243: 463–470.

    Article  PubMed  Google Scholar 

  • Iwasaki, H., Hirata, Y., Iwashina, M., Sato, K., Marumo, F. (1996) Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat. Endocrinology., 137: 3045–50.

    Article  PubMed  Google Scholar 

  • Kato, J., Kitamura, K., Kangawa, K. and Eto, T. (1995) Receptors for adrenomedullin in human vascular endothelial cells. Eur. J. Pharmacol., 289: 383–385.

    Article  PubMed  Google Scholar 

  • Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y. Matsuo, H. and Eto, T. (1992) Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. Biochem. Biophys. Res. Commun., 185: 134–141.

    Article  PubMed  Google Scholar 

  • Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y., Nakamura, S., Matsuo, H. and Eto, T. (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun., 192: 553–560.

    Article  PubMed  Google Scholar 

  • Kitamura, K., Kangawa, K., Kojima, M., Ichiki, Y., Matsuo, H. and Eto, T. (1994) Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor. FEBS Letters., 338: 6–10.

    Article  PubMed  Google Scholar 

  • Kobayashi, H. Yamamoto, R. Kitamura, K., Kuwasako, K. Minami, S., Yanagita, T. Shiraishi, S Yokoo, H., Eo, T., Wada, A. (2000) Selective inhibition of nicotinic receptors by proadrenimedullin N-terminal 12 peptide in bovine adrenal chromaffin cells. Molecular brain Reseach, 87: 175–183.

    Article  Google Scholar 

  • Macri, C.J., Martinez, A., Moody, T.W., Gray, K.D., Miller, M.J., Gallagher, M., Cuttitta, F. (1996) Detection of adrenomedullin, a hypotensive peptide, in amniotic fluid and fetal membranes. Am. J. Obstet. Gynecol., 175: 906–911.

    PubMed  Google Scholar 

  • Martinez, A., Cuttitta, F., Teitelman, G. (1998) Expression pattem for adrenomedullin during pancreatic development in the rat reveals a common precursor with other endocrine cell types. Cell Tissue Res., Jul; 293: 95–100.

    Google Scholar 

  • Martinez, A., Miller, M.J., Unsworth, E.J., Siegfried, J.M., and Cuttitta, F. (1995) Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology, 136: 4099–4105.

    Article  PubMed  Google Scholar 

  • Morris, H.R., Panico, M., Etienne, T., Tippins, J., Girgis, S.I. and Maclntyre, I. (1984) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature, 308: 768–748.

    Article  Google Scholar 

  • Nagata, N., Kato, J., Kitamura, K., Kawamoto, M., Tanaka, N., Eto, T., Takasaki, M. (1998) Dissociation of adrenomedullin concentrations in plasma and cerebrospinal fluid in pregnant and non-pregnant women. Eur J Endocrinol., 139: 611–614.

    Article  PubMed  Google Scholar 

  • Ohinata, K., Inui, A., Asakawa, A., Wada, K., Wada, E., Yoshikawa, M. (2000) Proadrenomedullin N-terminal 20 peptide (PAMP) elevates blood glucose levels via bombesin receptor in mice. FEBS Lett., 473: 207–211.

    Article  PubMed  Google Scholar 

  • Okazaki, T., Ogawa, Y., Tamura, N., Mori, K., Isse, N., Aoki, T., Rochelle, J.M., Taketo, M.M., Seldin, M.F, Nakao, K. (1996) Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene. Genomics.,: 37: 395–399.

    Article  PubMed  Google Scholar 

  • Roh J, Chang CL, Bhalla A, Klein C, Hsu SY. (2004) Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem. 279:7264–7274.

    Article  PubMed  Google Scholar 

  • Sakata, J., Shimokubo, T., Kitamura, K., Nakamura, S., Kangawa, K., Matsuo H. and Eto, T. (1993) Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem. Biophys. Res. Commun., 195: 921–927.

    Article  PubMed  Google Scholar 

  • Sakata, J., Shimokubo, T. Kitamura, K., Nishizono, M., Ichiki, Y., Kangawa, K., Matsuo, H., and Eto, T. (1994) Distribution and characterization of immunoreactive adrenomedullin in rat tissue and plasma. FEBS Letters., 352:105–108

    Article  PubMed  Google Scholar 

  • Samson, W.K., Murphy, T.C., Resch, Z.T. (1998) Proadrenomedullin N-terminal 20 peptide inhibits adrenocorticotropin secretion from cultured pituitary cells, possibly via activation of a potassium channel. Endocrine., 9: 269–272.

    Article  PubMed  Google Scholar 

  • Shimosawa, T., Ando, K., Fujita, T. 1997) A newly identifed peptide, proadrenomedullin N-terminal 20 peptide, induces hypotensive action via pertussis toxin-sensitive mechanisms. Hypertension., 30: 1009–1014.

    Google Scholar 

  • Shimosawa, T., Ito, Y., Ando, K., Kitamura, K., Kangawa, K. and Fujita, T. (1995) Proadrenomedullin NH2-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings. J. Clin. Invest., 96: 1672–1676.

    PubMed  Google Scholar 

  • Sugo, S., Minamino, N., Kangawa, K., Miyamoto, K., Kitamura, K., Sakata, J., Eto, T. and Matsuo, H. (1994a) Endothelial cells actively synthesize and secrete adrenomedullin. Biochem. Biophys. Res. Commun., 202: 1160–1166.

    Article  Google Scholar 

  • Sugo, S., Minamino, N., Shoji, H., Kangawa, K., Kitamura, K., Eto, T. and Matsuo, H. (1994b) Production and secretion of adrenomedullin from vascular smooth muscle cells. Augmented production by tumor necrosis factor-alpha. Biochem. Biophys. Res. Commun., 203: 719–726.

    Article  PubMed  Google Scholar 

  • Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S. (2004) Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS Lett., 56: 53–58.

    Article  Google Scholar 

  • Tsuruda, T., Kato, J., Kitamura, K., Kuwasako, K., Imamura, T., Koiwaya, Y., Tsuji, T., Kangawa, K., Eto, T. (1998) Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes. Hypertension, 31: 505–510.

    PubMed  Google Scholar 

  • Ueta, Y., Kitamura, K., Isse, T., Shibuya, I., Kabashima, N., Yamamoto, S., Kangawam, K., Matsuo, H., Eto, T., Yamashita, H. (1995) Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat. Neurosci. Lett., 202: 37–40.

    Article  PubMed  Google Scholar 

  • Washimine, H., Asada, Y., Kitamura, K., Ichiki, Y., Hara, S., Yamamoto, Y., Kangawa, K., Sumiyoshi, A. and Eto, T. (1995) Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue. Histochem. Cell Biol., 103: 251–25

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan

    Kazuo Kitamura & Tanenao Eto

  2. National Cardiovascular Research Institute, Suita, Osaka, Japan

    Kenji Kangawa

Authors
  1. Kazuo Kitamura
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  2. Kenji Kangawa
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  3. Tanenao Eto
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Editor information

Editors and Affiliations

  1. Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan

    Toshio Nishikimi MD, PhD

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Kitamura, K., Kangawa, K., Eto, T. (2005). Biochemistry of Adrenomedullin. In: Nishikimi, T. (eds) Adrenomedullin in Cardiovascular Disease. Basic Science for the Cardiologist, vol 19. Springer, Boston, MA. https://doi.org/10.1007/0-387-25405-6_1

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  • DOI: https://doi.org/10.1007/0-387-25405-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25404-3

  • Online ISBN: 978-0-387-25405-0

  • eBook Packages: MedicineMedicine (R0)

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