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Sliding Filament Mechanism in Muscle Contraction pp 45–60Cite as

X-Ray Diffraction Studies of Striated Muscles

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 565))

7. Conclusion

In this short review a number of recent X-ray diffraction results on the highly ordered striated muscles in insects and in bony fish have been briefly described. What is clear is that this technique applied to muscles which are amenable to rigorous analysis, taken together with related data from other sources (e.g. protein crystallography, biochemistry, mechanics, computer modelling) can provide not only the best descriptions yet available on the myosin head organisations on different myosin filaments in the relaxed state, but can also show the sequence of molecular events that occurs in the contractile cycle, and may also help to explain such phenomena as stretch-activation. X-ray diffraction is clearly an enormously powerful tool in studies of muscle. It has already provided a wealth of detail on muscle ultrastructure; it is providing ever more fascinating insights into molecular events in the 50-year old sliding filament mechanism, and there remains a great deal more potential that is as yet untapped.

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Authors and Affiliations

  1. Biological Structure and Function Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Exhibition Road, London, SW7 2AZ, UK

    John M. Squire, Carlo Knupp, Hind A. AL-Khayat, Felicity Eakins, Ngai-Shing Mok & Jeffrey J. Harford

  2. School of Optometry and Vision Sciences, University of Cardiff, Cardiff, CF10 3NB

    Carlo Knupp

  3. ESRF, rue Jules Horowitz, Grenoble, France

    Manfred Roessle

  4. BioCAT, Dept. Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, IL, 60616, USA

    Thomas C. Irving

  5. Dept of Cell Biology, Duke University, Durham, NC, 27710, USA

    Michael K. Reedy

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  1. John M. Squire
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  4. Hind A. AL-Khayat
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Editors and Affiliations

  1. Teiko University, Tokyo, Japan

    Haruo Sugi

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Squire, J.M. et al. (2005). X-Ray Diffraction Studies of Striated Muscles. In: Sugi, H. (eds) Sliding Filament Mechanism in Muscle Contraction. Advances in Experimental Medicine and Biology, vol 565. Springer, Boston, MA. https://doi.org/10.1007/0-387-24990-7_5

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  • DOI: https://doi.org/10.1007/0-387-24990-7_5

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