Skip to main content
SpringerLink
Log in

Inflammatory Response to Metals and Ceramics

  • Chapter
Integrated Biomaterials Science

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 379.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agins, H.J., Alcock, N.W., Bansal, M., Salvati, E.A., Wilson, P.D., Pellicci, P.M., Bullough, P. G. 1988. Metallic wear in failed titanium alloy total hip replacements. A histological and quantitative analysis, J. Bone Jt. Surg. 70, 347–356.

    Google Scholar 

  • al-Saffar, N., Mah, J.T., Kadoya, Y., Revell, P.A. 1995a. Neovascularisation and the induction of cell adhesion molecules in response to degradation products from orthopaedic implants, Ann. Rheum. Dis. 54, 201–208.

    Article  Google Scholar 

  • al-Saffar, N., Revell, P.A., Khwaja, H.A. Bonfield, W. 1995b. Assessment of the role of cytokines in bone resorption in patients with total joint replacement, J. Mat. Sci. Mater. Med. 6, 762–767.

    Google Scholar 

  • Alenius, H., Palosuo, T., Kelly, K., Kurup, V., Reunala, T., Makinen-Kiljunen, S., Turjanmaa, K., Fink, J. 1993. IgE reactivity to 14 KD and 27 KD natural rubber proteins in latex allergic children with spina bifida and other congenital anomalies, Int. Arch. Allerg. Immunol. 102, 61–66.

    Google Scholar 

  • Alliot-Licht, B., Jean, A., Gregoire, M. 1994. Comparative effect of calcium hydroxide and hydroxyapatite on the cellular activity of human pulp fibroblasts in vitro, Arch. Oral Biol. 39, 481–489.

    Google Scholar 

  • Amstutz, H.C., Grigoris, P. 1996. Metal on metal bearings in hip arthroplasty, Clin. Orthop. s329, S11–34.

    Google Scholar 

  • Arnaout, M.A. 1990. Structure and function of the leukocyte adhesion molecules CD11/CD18, Blood 75, 1037–1050.

    Google Scholar 

  • Beard, R.B., Carim, H., De Rosa, J.F., Dubin, S., Koerner, R., Miller, A.S. 1976. Biocompatibility of electrodes for implantable power sources, in: Biocompatibility of Implant Materials (D.F. Williams, ed.), Chap. 16, Sector Publishing, London.

    Google Scholar 

  • Biselli, R., Matricardi, P.M., D’Amelip, R., Fattorossi, A. 1992. Multiparametric flow cytometric R., analysis of the kinetics of surface molecule expression after polyclonal activation of human peripheral blood T lymphocytes, Scand. J. Immunol. 35, 439–447.

    Google Scholar 

  • Bjurholm, A., al-Tawil, N.A., Marcusson, J.A., Netz, P. 1990. The lymphocyte response to nickel salt in patients with orthopedic implants, Acta Orthop. Scand. 61, 248–250.

    Google Scholar 

  • Blaheta, R.A., Franz, M., Auth, M.K.H., Wenish, H.J.C., Markus, B.H. 1991. A rapid nonradioactive fluorescence assay for the measurement of both cell number and proliferation, J. Immunol. Meth., 142, 199–206.

    Article  Google Scholar 

  • Blaine, T.A., Pollice, P.F., Rosier, R.N., Reynolds, P.R., Puzas, J.E., O’Keefe, R.J. 1997. Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms, J. Bone Jt. Surg., Am. Vol. 79, 1519–1528.

    Google Scholar 

  • Bloebaum, R.D., Lundeen, G.A., Bachus, K.N., Ison, I., Hofmann, A.A. 1998. Dissolution of partiulate hydroxyapatite in a macrophage organelle model, J. Biomed Mater. Res. 40, 104–114.

    Article  Google Scholar 

  • Bohne, W., Pouezat, J.A., Peru, L., Daculsi, G. 1993. Heating of calcium phosphate crystals: morphological consequences and biological implications, Cells Mater. 3, 377–382.

    Google Scholar 

  • Bosetti, M., Ottani, V., Kozel, D., Raspanti, M., De Pasquale, V., Ruggeri, A., Cannas, M. 1999. Structural and functional macrophages alterations by ceramics of different composition, Biomaterials 20, 363–370.

    Article  Google Scholar 

  • Boyden, S. 1962. The chemotactic effect of mixtures antibody and antigen on polymorphonuclear leucocytes, J. Exp. Med. 115, 453–458.

    Article  Google Scholar 

  • Campoccia, D., Hunt, J.A., Doherty, P.J., Zhong, S.P., Callegaro, L., Benedetti, L., Williams, D.F. 1993. Human neutrophil chemokinesis and polarization induced by hyaluronic acid derivatives, Biomaterials 14, 1135–1139.

    Article  Google Scholar 

  • Cancilleri, F., De Giorgis, P., Verdoia, C., Parrini, L., Lodi, A., Crosti, C. 1992. Allergy to components of total hip arthroplasty before and after surgery, Ital. J. Orthop. Traumatol. 18, 407–410.

    Google Scholar 

  • Carlsson, A., Moller, H. 1989. Implantation of orthopaedic devices in patients with metal allergy, Acta Derm. Venereol. 69, 62–66.

    Google Scholar 

  • Carlsson, A., Magnusson, B., Moller, H. 1980. Metal sensitivity in patients with metal-to-plastic total hip arthroplasties, Acta Orthop. Scand. 51, 57–62.

    Google Scholar 

  • Carracedo, J., Ramirez, R., Martin Malo, A., Rodriguez, M., Aljama, P. 1998. Nonbiocompatible hemodialysis membranes induce apoptosis in mononuclear cells: the role of G-protein, J. Am. Soc. Nephrol. 9, 46–53.

    Google Scholar 

  • Case, C.P., Langlamer, V.G., James, C., Palmer, M.R., Kemp, A.J., Heap, P.F., Solomon, L. 1994. Widespread dissemination of metal debris from implant, J. Bone Jt. Surg. Br. Vol. 76, 701–712.

    Google Scholar 

  • Cheung, H.S., Haak, M.H. 1989. Growth of osteoblasts on porous calcium phosphate ceramics: an in vitro model for biocompatibility study, Biomaterials 10, 63–67.

    Article  Google Scholar 

  • Chiba, J., Rubash, H.E., Kim, K.J., Iwaki, Y. 1994. The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis, Clin. Orthop. 300, 304–312.

    Google Scholar 

  • Ciapetti, G., Roda, P., Landi, L., Facchini, A., Pizzoferrato, A. 1992. In vitro methods to evaluate metal-cell interactions, Int. J. Artif. Organs 15, 62–66.

    Google Scholar 

  • Ciapetti, G., Cenni, E., Pratelli, L., Pizzoferrato, A. 1993. In vitro evaluation of cell/biomaterial interaction by MTT assay, Biomaterials 14(5), 359–364.

    Article  Google Scholar 

  • Ciapetti, G., Granchi, D., Verri, E., Savarino, L., Savioli, F., Dallari, D., Gualtieri, G., Pizzoferrato, A. 1997. Effect of metal ions on leucocytes from patients with metal implants, 13th European Conference on Biomaterials, Goteborg (Sweden), 4–7 September 1997, Abstract P127.

    Google Scholar 

  • Ciapetti, G., Granchi, D., Verri, E., Savarino, L., Cenni, E., Savioli, F., Pizzoferrato, A. 1998. Fluorescent microplate assay for respiratory burst of PMNs challenged in vitro with orthopedic metals, J. Biomed. Mater. Res. 41, 455–460.

    Article  Google Scholar 

  • Daculsi, G., Passuti, N. 1990a. Effect of the macroporosity for osseous substitution of calcium phosphate ceramics, Biomaterials 11, 86–87.

    Google Scholar 

  • Daculsi, G., LeGeros, R.Z., Heughebaert, J.C., Barbieux, I. 1990. Formation of carbonate-apatite crystals after implantation of calcium phosphate ceramics, Calcif. Tissue Int. 46, 20–27.

    Google Scholar 

  • Daniels, A.U., Barnes, F.H., Charlebois, S.J., Smith, R.A. 2000. Macrophage cytokine response to particles and lypopolysaccharide in vitro, J. Biomed. Mater. Res. 49, 469–478.

    Article  Google Scholar 

  • Darzynkievicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M.A., Lassota, P., Traganos, F. 1992. Features of apoptotic cells measured by flow cytometry, Cytometry 13, 795–808.

    Google Scholar 

  • de Groot, K. 1983. Ceramics of calcium phosphates, preparation and properties, in: Bioceramics of Calcium-Phosphate (de Groot K, ed.), pp. 99–114, CRC Press, Boca Raton.

    Google Scholar 

  • de Groot, K., Wolke, J.G.C., Jansen, J.A. 1998. Calcium phosphate coatings for medical implants, J. Eng. Med. 212, 137–148.

    Article  Google Scholar 

  • Deutman, R., Mulder, T.J., Brian, R., Nater J.P. 1977. Metal sensitivity before and after total hip arthroplasty, J. Bone Jt. Surg. Am. Vol. 59, 862–865.

    Google Scholar 

  • Dobbs, H.S., Minski, M.J. 1980. Metal ion release after total hip replacement, Biomaterials 1, 193–198.

    Article  Google Scholar 

  • Dowsett, S.A., Hyvonen, P.M., Kowolik, M.J. 1997. Functional integrity of human neutrophils following 24 hour incubation with hydroxyapatite and fluoride, J. Biolumin. Chemilumin. 12, 215–221.

    Article  Google Scholar 

  • Ducheyne, P., Lemons, J.E. (eds.), 1988. Bioceramics: Materials Characteristics versus In Vivo Behavior, NY Academic Science, New York.

    Google Scholar 

  • Ducheyne, P., Qiu, Q. 1999. Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function, Biomaterials 20, 2287–2303.

    Article  Google Scholar 

  • Dupraz, A., Delecrin, J., Moreau, A., Pilet, P., Passuti, N. 1998. Long-term bone response to particulate injectable ceramic, J. Biomed. Mater. Res. 42, 368–375.

    Article  Google Scholar 

  • Elwing, H., Tengvall, P., Askendal, A., Lundstrom, I. 1991. “Lens-on-surface”: a versatile method for the investigation of plasma protein exchange reactions on solid surfaces, J. Biomater. Sci. Polym. Ed. 3, 7–15.

    Google Scholar 

  • Endler, M., Endler, T.A., Zielinski, C. 1982. Influence of hip arthroplasty upon chemotactic behaviour of leucocytes, Acta Orthop. Scand. 53, 795–799.

    Google Scholar 

  • Freyria, A.M., Chignier, E., Guidollet, J., Luisot, P. 1991. Peritoneal macrophage response: an in vivo model for the study of synthetic materials, Biomaterials 12, 111–118.

    Article  Google Scholar 

  • Fukuchi, N., Akao, M., Sato, A. 1995. Effect of hydroxyapatite microcrystals on macrophage activity, Biomed. Mater. Eng. 5, 219–231.

    Google Scholar 

  • Gangarosa, E.J., Inglefield, J.T., Thomas, C.G.A., Morgan, H.R. 1955. Studies on hypersensitivity of human tissues in vitro, J. Exp. Med. 101, 425–433.

    Google Scholar 

  • Giudiceandrea, F., lacona, A., Cervelli, G., Grimaldi, M., Maggiulli, G., Cococcetta, N., Cervelli, V. 1998. Mechanisms of bone resorption: analysis of proinflammatory cytokines in peritoneal macrophages from titanium implant — an experimental design, J. Craniofac. Surg. 9, 254–259.

    Google Scholar 

  • Glant T.T., Jacobs, J.J., Molnar, G., Shanbhag, A.S., Valyon, M., Galante, J.O. 1993. Bone resorption activity of particulate-stimulated macrophages, J. Bone Miner. Res. 8, 1071–1079.

    Article  Google Scholar 

  • Goebeler, M., Meinardus-Hager, G., Roth, J., Goerdt, S. and Sorg, C., 1993, Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells, J. Invest. Dermatol. 100, 759–765.

    Article  Google Scholar 

  • Goebeler, M., Roth, J., Brocker, E.B., Sorg, C., Schulze-Osthoff, K. 1995. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt, J. Immunol. 155, 2459–2467.

    Google Scholar 

  • Goldring, S.R., Jasty, M., Roelke, M.S., Rourke, C.M., Bringhurst, F.R., Harris, W.H. 1986 Formation of a synovial-like membrane at the bone-cement interface: its role in bone resorption and implant loosening after total hip replacement, Arthritis Rheumatol. 29, 836–842.

    Google Scholar 

  • Gonzales, J.B., Purdon, M.A., Horowitz, S.M. 1996. In vitro studies on the role of titanium in aseptic loosening, Clin. Orthop. 330, 244–250.

    Google Scholar 

  • Goodman, S.B., Fornasier, V.L., Lee, J., Kei, J. 1990. The effects of bulk versus particulate titanium and cobalt chrome alloy implanted into the rabbit tibia, J. Biomed. Mater. Res. 24, 1539–1549.

    Google Scholar 

  • Goodman, S.B., Aspenberg, P., Spang, Y., Doshi, A., Regula, D., Lidgren L. 1995. Effects of particulate high-density polyethylene and titanium alloy on tissue ingrowth into bone harvest chamber in rabbits, J. Appl. Biomater. 6, 27–33.

    Google Scholar 

  • Goodman, S.B., Davidson, J.A., Song, Y., Martial, N., Fornasier, V.L. 1996a. Histomorphological reaction of bone to different concentrations of phagocytosable particles of high-density polyethylene and Ti-6A1-4V alloy in vivo, Biomaterials, 17, 1943–1947.

    Google Scholar 

  • Goodman, S.B., Knoblich, G., O’connor, M., Song, Y., Huie, P., Sibley, R. 1996b. Heterogeneity in cellular and cytokine profiles from multiple samples of tissue surrounding revised hip prostheses, J. Biomed. Mater. Res. 31, 421–428.

    Article  Google Scholar 

  • Granchi, D., Ciapetti, G., Stea, S., Cavedagna, D., Bettini, N., Bianco, T., Fontanesi, G., Pizzoferrato, A. 1995. Evaluation of several immunological parameters in patients with aseptic loosening of hip arthroplasty, Chir. Organi Mov. 80, 399–408.

    Google Scholar 

  • Granchi, D., Verri, E., Ciapetti, G., Savarino, L., Cenni, E., Gori, A., Pizzoferrato, A. 1998a. Effects of chromium extract on cytokine release by mononuclear cells, Biomaterials 19, 283–291.

    Google Scholar 

  • Granchi, D., Verri, E., Ciapetti, G., Stea, S., Savarino, L., Sudanese, A., Mieti, M., Rotini, R., Dallari, D., Zinghi, G., Montanaro, L. 1998b. Bone resorbing cytokines in serum of patients with aseptic loosening of hip prosthesis, J. Bone Jt. Surg. 80, 912–917.

    Google Scholar 

  • Granchi, D., Cenni, E., Ciapetti, G., Savarino, L., Stea, S., Gamberini, S., Gori, A., Pizzoferrato, A. 1998c. Cell death induced by metal ions, necrosis or apoptosis? J. Mater. Sci., Mater. Med. 9, 31–37.

    Article  Google Scholar 

  • Granchi, D., Ciapetti, G., Stea, S., Savarino, L, Filippini, F., Sudanese, A., Zinghi, G., Montanaro L. 1999. Cytokine release in mononuclear cells of patients with Co-Cr hip prosthesis, Biomaterials 20, 1079–1086.

    Article  Google Scholar 

  • Greppi, A.L., Smith, D.C., Woodside, D.G. 1989. Nickel hypersensitivity reactions in orthodontic patients. A literature review, Univ. Tor. Dent. J. 3, 11–14.

    Google Scholar 

  • Gruber, H.E. 1991. Bone and the immune system, Proc. Soc. Exp. Biol. Med. 197, 219–225.

    Google Scholar 

  • Harada, Y., Wang, J.T., Doppalapudi, V.A., Willis, A.A., Jasty, M., Harris, W.H., Nagase, M., Goldring, S.R. 1996. Differential effects of different forms of hydroxyapatite and hydroxyapatite/tricalcium phosphate particulates on human monocyte/macrophages in vitro, J. Biomed. Mater. Res. 31, 19–26.

    Article  Google Scholar 

  • Harms, J., Mausle, E. 1979. Tissue reaction to ceramic implant material, J. Biomed. Mater. Res. 13(1), 67–87.

    Article  Google Scholar 

  • Haynes, D.R., Rogers, S.D., Hay, S., Pearcy, M.J., Howie, D.W. 1993. The difference in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles, J. Bone Jt. Surg., Am. Vol. 75, 825–834.

    Google Scholar 

  • Haynes, D.R., Rogers, S.D., Howie, D.W., Pearcy, M.J., Vernon-Roberts, B. 1996. Drug inhibition of the macrophage response to metal wear particles in vitro, Clin. Orthop. 323, 316–326.

    Google Scholar 

  • Haynes D.R., Hay, S.J., Rogers, S.D., Ohta, S., Howie, D.W., Graves, S.E. 1997. Regulation of bone cells by particle-activated mononuclear phagocytes, J. Bone Jt. Surg., Br. Vol. 79, 988–994.

    Google Scholar 

  • Haynes, D.R., Boyle, S.J., Rogers, S.D., Howie, D.W., Vernon-Roberts, B. 1998. Variation in cytokines induced by particles from different prosthetic materials, Clin. Orthop. 352, 223–230.

    Google Scholar 

  • Haynes, D.R., Crotti, T.N., Haywood, M.R. 2000. Corrosion of and changes in biological effects of cobalt chrome alloy and 316L stainless steel prosthetic particles with age, J. Biomed. Mater. Res. 49, 167–175.

    Article  Google Scholar 

  • Heese, A., Peters, K.P., Koch, H. 1997. Type I allergies to latex and the aeroallergenic problem, Eur. J. Surg. Suppl. 579, 19–22.

    Google Scholar 

  • Hickmann, J.A., Boyle, C.C. 1996. Apoptosis and cytotoxins, Br. Med. Bull., 52, 632–643.

    Google Scholar 

  • Hirakawa, K., Bauer, T.W., Stulberg, B.N., Wilde, A.H. 1996. Comparison and quantitation of wear debris of failed total hip and knee arthroplasty, J. Biomed. Mater. Res. 31, 257–263.

    Article  Google Scholar 

  • Horowitz, S.M., Luchetti, W.T., Gonzales, J.B., Ritchie, C.K. 1998. The effects of cobalt chromium upon macrophages, J. Biomed. Mater. Res. 41, 468–473.

    Article  Google Scholar 

  • Hujanen E.S., Seppa S.T., Virtanen K. 1995. Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro, Biochim. Biophys. Acta 1245, 145–152.

    Google Scholar 

  • Hukkanen, M., Corbett, S.A., Batten, J., Konttinen, Y.T., McCarthy, I.D., Maclouf, J., Santavirta, S., Hughes, S.P., Polak, J.M. 1997. Aseptic loosening of total hip replacement. Macrophage expression of inducible nitric oxide synthase and cyclo-oxygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure, J. Bone Jt. Surg., Br. Vol. 79, 467–474.

    Google Scholar 

  • Hunt, J.A., Remes, A., Williams, D.F. 1992. Stimulation of neutrophil movement by metal ions, J. Biomed. Mater. Res. 26, 819–828.

    Article  Google Scholar 

  • Ibbotson, K.J., Twardzic, D.R., D’Souza, S.M., Hargreaves, W.A., Todaro, G.K., Mundy, G.R. 1985. Stimulation of bone resorption in vitro by systemic transforming growth factoralpha, Science 228, 1007–1011.

    Google Scholar 

  • Ishiguro, N., Kojima, T., Ito, T., Saga, S., Anma, H., Kurokouchi, K., Iwahori, Y., Iwase, T., Iwata, H. 1997. Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components, J. Biomed. Mater. Res. 35, 399–406.

    Article  Google Scholar 

  • Jacobs, J., Urban, R.M., Gilbert, J.L., Skipor, A.K., Black, J., Jasty, M., Galante, J.O. 1995. Local and distant products from modularity, Clin. Orthop. 319, 94–105.

    Google Scholar 

  • Jacobs, J., Skipor, A., Doorn, P., Campbell, P., Schmalzried, T., Black, J., Amstutz, H. 1996. Cobalt and chromium concentrations in patients with metal on metal total hip replacements, Clin. Orthop. 3295, S256–S263.

    Google Scholar 

  • Jahns, G., Haeffner-Cavaillon, N., Nyddegger, U.E., Kazatchkine, M.D. 1993. Complement activation and cytokine production as consequences of immunological bioincompatibility of extracorporeal circuits, Clin. Mater. 14, 303–336.

    Article  Google Scholar 

  • Jarcho, M., 1981, Calcium phosphate ceramics as hard tissue prosthetics, Clin. Orthop. Relat. Res. 157, 259–278.

    Google Scholar 

  • Jia, W., Beatty, M.W., Reinhardt, R.A., Petro, T.M., Cohen, D.M. 1999. Nickel release from orthodontic arch wires and cellular immune response to various nickel concentrations, J. Biomed. Mater. Res. 48, 488–495.

    Article  Google Scholar 

  • Jiranek, W.J., Machado, M., Jasty, M., Jesevar, D., Wolfe, H.J., Goldring, S.R., Goldberg M.J., Harris, W.H. 1993. Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization, J. Bone Jt. Surg., Am. Vol. 75, 863–879.

    Google Scholar 

  • Kanagaraja, S., Lundstrom, I., Nygren, H., Tengvall, P. 1996. Platelet binding and protein adsorption to titanium and gold after short time exposure to heparinized plasma and whole blood, Biomaterials 17, 2225–2235.

    Article  Google Scholar 

  • Kane, DeHeer, D.H., Owens, S.R., Beebe, J.D., Swanson, A.B. 1994. Adsorption of collagenase to particulate titanium: a possible mechanism for collagenase localization in periprosthetic tissue, J. Appl. Biomater. 5, 353–360.

    Article  Google Scholar 

  • Kansas, G.S., 1992, Structure and function of L-selectin, APMIS 100, 287–293.

    Article  Google Scholar 

  • Kaplan, S.S., Basford, R.E., Kormos, R.L., Hardesty, R.L., Simmons, R.L., Mora, E.M., Cardona, M., Griffith, B.L. 1990. Biomaterial associated impairment of local neutrophil function, ASAIO Trans. 36, M172–175.

    Google Scholar 

  • Kaplan, S.S., Simmons, R.L. 1995. Neutrophil biomaterial interactions: implications for host defense and inflammation, in: Encyclopedic Handbook of Biomaterials and Bioengineering, Part A: Materials, Vol. 1 (D.L. Wise, D.J. Trantolo, D.E. Altobelli, M.J. Yaszemski, J.D. Gresser, E.R. Schwartz, eds.), pp. 457–491, Marcel Dekker, Inc., New York.

    Google Scholar 

  • Katou, F., Andoh, N., Motegi, K., Nagura, H. 1996. Immuno-inflammatory responses in the tissues adjacent to titanium miniplates used in the treatment of mandibular fractures, J. Craniomaxillofac. Surg. 24, 155–162.

    Google Scholar 

  • Kim, H., Johnson, J.W. 1999. Corrosion of stainless steel, nickel-titanium, coated nickeltitanium, and titanium orthodontic wires, Angle Orthod. 69, 39–44.

    Google Scholar 

  • Kim, K.J., Sato, K., Kotake, S., Katoh, Y., Itoh, T. 1993. Biochemical and histochemical analysis of bone marrow cells activated by HA particles, in: Bioceramics, Vol. 6 (P. Ducheyne, D. Christiansen, eds.), pp. 365–369, Butterworth-Heinemann Ltd., Philadelphia.

    Google Scholar 

  • Klein, C.L., Nieder, P., Wagner, M., Kohler, H., Bittinger, F., Kirkpatrick, C.J., Lewis, J.C. 1994. The role of metal corrosion in inflammatory processes: induction of adhesion molecules by heavy metal ions, J. Mater. Sci., Mater. Med. 5, 798–807.

    Google Scholar 

  • Klein, C.P., Driessen, A.A., de Groot, K. 1983a. Biodegradation behaviour of various calcium phosphate materials in bone tissue, J. Biomed. Mater. Res. 17, 769–784.

    Article  Google Scholar 

  • Klein, C.P., de Groot, K., van Kamp, G. 1983b. Activation of complement C3 by different calcium phosphate powders, Biomaterials 4, 181–184.

    Article  Google Scholar 

  • Korkusuz, F., Uluoglu, O. 1999. Non-specific inflammation and bone marrow depletion due to intramedullary porous hydroxyapatite application, Bull. Hosp. Jt. Dis. 58, 86–91.

    Google Scholar 

  • Kubo, T., Sawada, K., Hirakawa, K., Shimizu, C., Takamatsu, T., Hirasawa, Y. 1999. Histiocyte reaction in rabbit femurs to UHMWPE, metal, and ceramic particles in different sizes, J. Biomed. Mater. Res. 45, 363–369.

    Article  Google Scholar 

  • Labat, B., Chamson, A., Frey, C. 1995. Effects of γ-alumina and hydroxyapatite coatings on the growth and metabolism of human osteoblasts, J. Biomed. Mater. Res. 29, 1397–1401.

    Article  Google Scholar 

  • Lalor, P.A., Revell, P.A. 1993. T-lymphocytes and Titanium Aluminium Vanadium (TiA1Va) alloy: evidence for immunological events associated with debris deposition, Clin. Mater., 12, 57–62.

    Article  Google Scholar 

  • Le Huec, J.C., Schaeverbeke, T., Clement, D., Faber, J., Le Rebeller, A. 1995. Influence of porosity on the mechanical resistance of hydroxy-apatite ceramics under compressive stress, Biomaterials 16, 113–118.

    Google Scholar 

  • Lee, S.H., Brennan, F.R., Jacobs, J.J., Urban, R.M., Ragasa, D.R., Glant, T.T. 1997. Human monocyte/macrophage response to cobalt-chromium corrosion products and titanium particles in patients with total joint replacements, J. Orthop. Res. 15, 40–49.

    Google Scholar 

  • LeGeros, R.Z., Zheng, R., Kijkowska, R., Fan, D., LeGeros, J.P. 1994. Variations in composition and crystallinity of “hydroxyapatite (HA)” preparations, in: Characterization and Performance of Calcium Phosphate Coatings for Implants (E. Horowitz, J.E. Parr, eds.), pp. 45–53, ASTM STP 1196, American Society for Testing and Materials, Philadelphia.

    Google Scholar 

  • Lerouge, S., Huk, O., Yahia, L.H., Witvoet, J., Sedel, L. 1996. Characterization of in vivo wear debris from ceramic-ceramic total hip arthroplasties, J. Biomed. Mater. Res. 32, 627–633.

    Article  Google Scholar 

  • Lindholm, T.C., Gao, T.J., Lindholm, T.S. 1996. Time-related deviations of fibronectin and type I, II and III collagen on the interface between a hydroxyapatite disc and the rim of a calvarial trephine defect in rabbits, Biomaterials 17, 1515–1520.

    Article  Google Scholar 

  • Liu, H.C., Chang, W.H., Lin, F.H., Lu, K.H., Tsuang, Y.H., Sun, J.S. 1999. Cytokine and prostaglandin release from leukocytes in response to metal ions derived from different prosthetic materials: an in vitro study, Artif. Organs 23, 1099–1106.

    Article  Google Scholar 

  • Lohmann, C.H., Schwartz, Z., Zoster, G., Jahn, U., Buchhorn, G.H., MacDougall, M.J., Casasola, D., Liu, Y., Sylvia, V.L., Dean, D.D., Boyan, B.D. 2000. Phagocytosis and wear debris by osteoblasts affects differentiation and local factor production in a manner dependent on particle composition, Biomaterials, 21, 551–561.

    Google Scholar 

  • Lycott, R.W., Hughes, A.N. 1984. Corrosion, in: Metal and Ceramic Biomaterials, Vol. 2 (P. Ducheyne, G.W. Hastings, eds.) pp. 91–118, CRC Press, Boca Raton.

    Google Scholar 

  • MacNamara, A., Crowley, H.K., Williams, D.F. 1984. Metal-cell incubation products: chemotactic potential, in: Biomaterials and Biomechanics 1983, “Advances in Biomaterials 5” (P. Ducheyne, G. Van der Perre, A.E. Aubert, eds.), pp. 307–312, Elsevier Science Publishers B.V., Amsterdam.

    Google Scholar 

  • Malard, O., Bouler, J.M., Guicheux, J., Heymann, D., Pilet, P., Coquard, C., Daculsi, G. 1999. Influence of biphasic calcium phosphate granulometry on bone ingrowth, ceramic resorption, and inflammatory reactions: preliminary in vitro and in vivo study, J. Biomed. Mater. Res. 46, 103–111.

    Article  Google Scholar 

  • Maloney, W.J., James, R.E., Smith, R.L. 1996. Human macrophages response to retrieved titanium alloy particles in vitro, Clin. Orthop. 322, 268–278.

    Google Scholar 

  • Maloney, W.J., Sun, D.H., Nakashima, Y., James, R., Smith, R.L. 1998. Effects of serum protein opsonization on cytokine release by titanium-alloy particles, J. Biomed. Mater. Res. 41, 371–376.

    Article  Google Scholar 

  • Mangham, D.C., Scoones, D.J., Drayson, M.T. 1993. Complement and the recruitment of mononuclear osteoclasts, J. Clin. Pathol. 46, 517–521.

    Google Scholar 

  • Marchant, R., Hiltner, A., Hamlin, C., Rabinovitch, A., Slobodkin, R., Anderson, J.M. 1983. In vivo biocompatibility studies: I. The cage implant system and a biodegradable hydrogel, J. Biomed. Mater. Res. 17, 301–325.

    Article  Google Scholar 

  • McAlarney, M.E., Oshiro, M.A., McAlarney, C.V. 1996. Effects of titanium dioxide passive film crystal structure, thickness, and crystallinity on C3 adsorption, Int. J. Oral Maxillofac. Implants 11, 73–80.

    Google Scholar 

  • Mebius, R.E., Watson, S.R. 1993. Land E-selectin can recognize the same naturally occurring ligands on high endothelial venules, J. Immunol. 151, 3252–3360.

    Google Scholar 

  • Merkel, K.D., Erdmann, J.M., McHugh, K.P., Abu-Amer, Y., Ross, F.P., Teitelbaum, S.L. 1999. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis, Am. J. Pathol. 154, 203–210.

    Google Scholar 

  • Merritt, K. 1986. Hypersensitivity induction, in Handbook of Biomaterials Evaluation (A.F. Von Recuum, ed.), pp. 179–187, Macmillan Publishing Company, New York.

    Google Scholar 

  • Merritt, K., Brown, S.A. 1985. Biological effects of corrosion products from metal, in: Corrosion and Degradation of Implant Materials (A.C. Fraker, C.D. Griffith, eds.), pp. 195–207, Second Symposium, ASTM STP 859, American Society for Testing and Materials, Philadelphia.

    Google Scholar 

  • Merritt, K., Brown, S.A. 1996. Distribution of cobalt chromium wear and corrosion products and biological reaction, Clin. Orthop. 329, S233–S243.

    Google Scholar 

  • Merritt, K., Mayor, M.B., Brown, S.A. 1980. Evaluation of sensitivity to metallic implants, in: Evaluation of Biomaterials (G. D. Winter, J.L. Leray, K. de Groot, eds.), pp. 315–324, J.Wiley & Sons, New York.

    Google Scholar 

  • Mu, Y., Kobayashi, T., Sumita, M., Yamamoto, A., Hanawa, T. 2000, Metal ion release from titanium with active oxygen species generated by rat macrophages in vitro, J. Biomed. Mater. Res. 49, 238–243.

    Article  Google Scholar 

  • Nagase, M. 1985. Antigenicity of alumina ceramic and calcium phosphate ceramics-genetic control of the immune response, Nippon Seikeigeka Gakkai Zasshi 59, 183–191.

    Google Scholar 

  • Nakashima, Y., Sun, D.H., Trindade, M.C., Chun, L.E., Song, Y., Goodman, S.B., Schurman, D.J., Maloney, W.J., Smith, R.L. 1999a. Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles, J. Bone Jt. Surg., Br. Vol. 81, 155–162.

    Google Scholar 

  • Nakashima, Y., Sun, D.H., Trindade, M.C., Maloney, W.J., Goodman, S.B., Schurman, D.J., Smith, R.L. 1999b. Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro, J. Bone Jt. Surg., Am. Vol. 81, 603–615.

    Google Scholar 

  • Nelson, R.D., Quie, P.G., Simmons, R.L. 1975. Chemotaxis under agarose, a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes, J. Immunol. 115, 1650–1656.

    Google Scholar 

  • Neo, M., Nakamura, T., Ohtsuki, C, Kokubo, T., Yamamuro, T. 1993. Apatite formation on three kinds of bioactive materials at an early stage in vivo: a comparative study by transmission electron microscopy, J. Biomed. Mater. Res. 27, 999–1006.

    Google Scholar 

  • Nichols, K.G., Puleo, D.A. 1997. Effect of metal ions on the formation and function of osteoclastic cells in vitro, J. Biomed. Mater. Res. 35, 265–271.

    Article  Google Scholar 

  • Nordsletten, L., Hogasen, A.K.M., Konttinen, Y.T., Santavirta, S., Aspenberg, P., Aasen, A.O. 1996. Human monocytes stimulation by particles of hydroxyapatite, silicon carbide and diamond: in vitro studies of new prosthesis coatings, Biomaterials 17, 1521–1527.

    Article  Google Scholar 

  • Papatheofanis, F.J., Barmada, R. 1991. Polymorphonuclear leukocyte degranulation with exposure to polymethylmethacrylate nanoparticles, J. Biomed. Mater. Res. 25, 761–771.

    Article  Google Scholar 

  • Pazzaglia, U.E., Ghisellini, F., Barbieri, D., Ceciliani, L. 1988. Failure of the stem in total hip replacement. A study of aetiology and mechanism of failure in 13 cases, Arch. Orthop. Trauma Surg. 107, 195–202.

    Article  Google Scholar 

  • Petty, W. 1978. The effect of methylmethacrylate on chemotaxis of polymorphonuclear leucocytes, J. Bone Jt. Surg. 60, 492–497.

    Google Scholar 

  • Picker, L.J., Treer, J.R., Ferguson-Darnell, B., Collins, P.A., Bergstresser, P.R., Terstappen L.W.M.M. 1993. Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte associated antigen, a tissue-selective homing receptor for skin homing T-cell, J. Immunol. 150, 1122–1136.

    Google Scholar 

  • Pitzalis, C., Cauli, A., Pipitone, N., Smith, C., Barker, J., Marchesoni, A., Yanni, G., Panayi, G.S. 1996. Cutaneous lymphocytes antigen-positive T lymphocytes preferentially migrate to the skin but not the joint in psoriatic arthritis, Arthritis Rheum. 39, 137–145.

    Google Scholar 

  • Pizzoferrato, A., Vespucci, A., Tarabusi, C., Ciapetti, G., Stea, S. 1984. Chemotactic response of macrophages from biomaterial injected mice, in: Biomaterials and Biomechanics 1983, Advances in Biomaterials 5 (P. Ducheyne, G. Van der Perre, A.E. Aubert, eds.), pp. 301–306, Elsevier Science Publishers B.V., Amsterdam.

    Google Scholar 

  • Pizzoferrato, A. Vespucci, S., Ciapetti, G., Stea, S. 1986. Chemotactic behavior of macrophages under biomaterial influence, in: Techniques of Biocompatibility Testing, Vol. II (D.F. Williams, ed.), pp. 110–121, CRC Press, Inc., Boca Raton.

    Google Scholar 

  • Pizzoferrato, A., Vespucci, A., Ciapetti, G., Stea, S., Tarabusi, C. 1987. The effect of injections of powdered biomaterials on mouse peritoneal cell populations, J. Biomed. Mater. Res. 21, 419–428.

    Article  Google Scholar 

  • Pizzoferrato, A., Ciapetti, G., Stea, S., Toni, A. 1991. Cellular events in the mechanisms of prosthesis loosening, Clin Mater. 7, 51–81.

    Article  Google Scholar 

  • Pollice, P.F., Hsu, J., Hicks, D.G., Bukata, S., Rosier, R.N., Reynolds, P.R., Puzas, J.E., O’Keefe, R.J. 1998. Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway, J. Orthop. Res. 16, 697–704.

    Article  Google Scholar 

  • Prabhu, A., Shelburne, C.E., Gibbons, D.F. 1998. Cellular proliferation and cytokine responses of murine macrophage cell line J774A.1 to polymethylmethacrylate and cobalt-chrome alloy particles, J. Biomed. Mater. Res. 42, 655–663.

    Article  Google Scholar 

  • Rader, C.P., Sterner, T., Jakob, F., Schutze, N., Eulert, J. 1999a. Cytokine response of human macrophage-like cells after contact with polyethylene and pure titanium particles, J. Anhroplasty 14, 840–848.

    Google Scholar 

  • Rader, C.P., Baumann, B., Sterner, T., Rolf, O., Hendrich, C, Schultze, N., Jakob, F. 1999b. secretion by human macrophage-like cells in response to wear particles and its modification by drugs, Biomed. Tech. (Berl.) 44, 135–141.

    Google Scholar 

  • Radin, S. and Ducheyne, P. 1994. Changes in characteristics arising from processing and the effect on in-vitro stability of calcium phosphate ceramics, in: Characterization and Performance of Calcium Phosphate Coatings for Implants, (E. Horowitz, J.E. Parr, eds.) pp. 111–123, ASTM STP 1196, American Society for Testing and Materials, Philadelphia.

    Google Scholar 

  • Ragab, A.A., Van De Motter, R., Lavish, S.A., Goldberg, V.M., Ninomiya, J.T., Carlin, C.R., Greenfield, E.M. 1999. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces, J. Orthop. Res. 17, 803–809.

    Article  Google Scholar 

  • Ramsey, W.S. 1972. Analysis of individual leucocyte behaviour during chemotaxis, Exp. Cell Res. 70, 129–139.

    Article  Google Scholar 

  • Remes, A., Williams, D.F. 1991a. Neutrophil polarization and immunoelectrophoresis assay in the study of complement activation by biomaterials, Biomaterials 12, 607–613.

    Google Scholar 

  • Remes, A., Williams, D.F. 1991b. Relationship between chemotaxis and complement activation by ceramic biomaterials, Biomaterials, 12, 661–667.

    Google Scholar 

  • Remes, A., Williams, D.F. 1992. Immune response in biocompatibility, Biomaterials 13, 731–743.

    Article  Google Scholar 

  • Rodgers, K., Klykken, P., Jacobs, J., Frondoza, C., Tomazic, V., Zelikoff, J. 1997. Immunotoxicity of medical devices, Fund. Appl. Tox. 36, 1–14.

    Google Scholar 

  • Rogers, S.D., Howie, D.W., Graves, S.E., Pearcy, M.J., Haynes, D.R. 1997. In vitro human monocytes response to wear particles of titanium alloy containing vanadium or niobium, J. Bone Jt. Surg., Br. Vol. 79, 311–315.

    Google Scholar 

  • Romagnani, S. 1992. Induction of Thl and Th2 response, a key role for the immune response? Immunol. Today 13, 379–381.

    Article  Google Scholar 

  • Rooker, G.D., Wilkinson, J.D. 1980. Metal sensitivity in patients undergoing hip replacement. A prospective study, J. Bone Jt. Surg., Br. Vol. 62, 502–505.

    Google Scholar 

  • Rose, N.R. 1997. Immunologic diagnosis of autoimmune disease, in: Handbook of Human Immunology, (M.S. Lefell, A.D. Donnenberg, N.R. Rose, eds.), pp. 111–123, CRC Press, Boca Raton.

    Google Scholar 

  • Ross, L., Benghuzzi, H., Tucci, M., Callender, M., Cason, Z., Spence, L. 1996. The effect of HA, TCP and ALCAP bioceramic capsules on the viability of human monocyte and monocyte derived macrophages, Biomed. Sci. Instrum. 32, 71–79.

    Google Scholar 

  • Rostoker, G., Robin, J., Binet, O., Blamoutier, J., Paupe, J., Leissana Leibowitch, M., Beduelle, J., Sonneck, J.M., Garrel, J.B., Millet P. 1987. Dermatitis due to orthopedic implants. A review of the literature and report of three cases, J. Bone Jt. Surg., Am. Vol. 9, 1408–1412.

    Google Scholar 

  • Rovira, A., Amedee, J., Bareille, R., Rabaud, M. 1996. Colonization of a calcium phosphate/ elastin-solubilized peptide-collagen composite material by human osteoblasts, Biomaterials 17, 1535–1540.

    Article  Google Scholar 

  • Sabokbar, A., Pandey, R., Quinn, J.M., Athanasou, N.A. 1998. Osteoclastic differentiation by mononuclear phagocytes containing biomaterial particles, Arch. Orthop. Trauma Surg. 117, 136–140.

    Article  Google Scholar 

  • Sasaoka, K, Seto, K, Tsugita, M., Tsuru, S. 1989. An immunological study of tricalcium phosphate supplied by three different manufacturers, J. Clin. Lab. Immunol. 30, 197–202.

    Google Scholar 

  • Savarino, L., Granchi, D., Ciapetti, G., Stea, S., Donati, M.E., Zinghi, G., Fontanesi, G., Rotini, R., Montanaro, L. 1999. Effects of metal ions on white blood cells of patients with failed total joint arthroplasties, J. Biomed. Mater. Res. 47, 543–550.

    Article  Google Scholar 

  • Savio, J.A., Overcamp, L.M., Black, J. 1994. Size and shape of biomaterial wear debris, Clin. Mater. 15, 101–147.

    Google Scholar 

  • Schedle, A., Samorapoompichit, P., Rausch-Fan, X.H., Franz, A., Füreder, W., Sperr, W.R., Sperr, W., Ellinger, A., Slavicek, R., Boltz-Nitulescu, G., Valent, P. 1995. Response of L929 fibroblast, human gingival fibroblasts and human tissue mast cells to various metal cations, J. Dent. Res. 74, 1513–1515.

    Google Scholar 

  • Schedle, A., Samorapoompichit, P., Füreder, W., Rausch-Fan, X.H., Franz, A., Sperr, W.R., Sperr, W., Slavicek, R., Simak, S., Klepekto, W., Ellinger, A., Ghannadan, M., Baghes-tanian, M., Valent, P. 1998. Metal ion-induced toxic histamine release from human basophils and mast cells, J. Biomed. Mater. Res. 39, 560–567.

    Article  Google Scholar 

  • Shahgaldi, B.F., Heatley F.W., Dewar A., Corrin, B. 1995. In vivo corrosion of cobalt-chromium and titanium wear particles. J. Bone Jt. Surg., Br. Vol. 77, 962–966.

    Google Scholar 

  • Shanbhag, A., Jacobs, J.J., Black, J., Galante, J.O., Glant, T.T. 1994. Macrophage/particle interactions: effect of size, composition and surface area, J. Biomed. Mater. Res. 28, 81–90.

    Article  Google Scholar 

  • Shanbhag, A., Jacobs, J.J., Black, J., Galante, J.O., Glant, T.T. 1995. Human monocyte response to particulate biomaterials generated in vivo and in vitro, J. Orthop. Res. 13, 792–801.

    Article  Google Scholar 

  • Stea, S., Visentin, M., Granchi, D., Melchiorri, C., Soldati, S., Sudanese, A., Toni, A., Montanaro, L., Pizzoferrato, A. 1999. Wear debris and cytokine production in the interface membrane of loosened prostheses, J. Biomat. Sci., Polym. Ed. 10, 236–247.

    Google Scholar 

  • Stea, S., Visentin, M., Granchi, D., Cenni, E., Ciapetti, G., Sudanese, A., Toni, A. 2000, Apoptosis in peri-implant tissue, Biomaterials 21, 1393–1398.

    Article  Google Scholar 

  • Stern, I.J., Kapsalis, A.A., DeLuca, B.L., Pieczynski, W. 1972. Immunogenic effects of foreign materials on plasma proteins, Nature 238, 151–152.

    Article  Google Scholar 

  • Sun, Z.L., Wataha, J.C., Hanks, C.T. 1997. Effects of metal ions on osteoblast-like cell metabolism, J. Biomed. Mater. Res. 34, 29–37.

    Google Scholar 

  • Takebe, J., Itoh, S., Ariake, T., Shioji, H., Shioyama, T., Ishibashi, K., Ishizawa, H. 1998. The effect on immunocytes of anodic oxide titanium after hydrothermal treatment, J. Biomed. Mater. Res. 42, 272–277.

    Article  Google Scholar 

  • Tang, L., Eaton, J.W. 1993. Fibrin(ogen) mediates acute inflammatory responses to biomaterials, J. Exp. Med. 178, 2147–2156.

    Article  Google Scholar 

  • Tang, L., Jennings, T.A., Eaton, J.W. 1998. Mast cell mediate acute inflammatory responses to implanted biomaterials, Proc. Natl. Acad. Sci. USA 95, 8841–8846.

    Google Scholar 

  • Thompson, G.J., Puleo, D.A. 1995. Effects of sublethal metal ion concentrations on osteogenic cells derived from bone marrow stromal cells, J. Appl. Biomater. 6, 249–258.

    Article  Google Scholar 

  • Timbrell, J.A. 1991. Principles of Biochemical Toxicology, Taylor & Francis, London.

    Google Scholar 

  • Tofe, A.J., Brewster, G.A., Bowerman, M.A., Myers, R.N., Hurson, S.M. 1994. Hydroxylapatite powders for implant coatings, in: Characterization and Performance of Calcium Phosphate Coatings for Implants (E. Horowitz, J.E. Parr, eds.), pp. 9–15, ASTM STP 1196, American Society for Testing and Materials, Philadelphia.

    Google Scholar 

  • Tomei, L.D., Cope, F.O. (eds.), 1991. Apoptosis: The Molecular Basis of Cell Death, Curent communication on cell and molecular biology, Vol. 3, Cold Spring Arbor, NY.

    Google Scholar 

  • Toumbis, C.A., Kronick, J.L., Wooley, P.H., Nasser S. 1997. Total joint arthroplasty and the immune response, Semin. Arthritis Rheum. 27, 44–47.

    Article  Google Scholar 

  • Trindade, M.C., Nakashima, Y., Lind, M., Sun, D.H., Goodman, S.B., Maloney, W.J., Schurman, D.J., Smith R.L. 1999. Interleukin-4 inhibits granulocyte-macrophage colony-stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethyl methacrylate particle challenge in vitro, J. Orthop. Res. 17, 797–802.

    Article  Google Scholar 

  • U.S. Department of Health and Human Services, Food and Drug Administration—Center for Devices and Radiological Health, Guidance for industry and FDA reviewers, Immunotoxicity Testing Guidance, Document issued on May 6, 1999, Pages 1–16.

    Google Scholar 

  • Van Raemdonck, W., Ducheyne, P., De Meester, P. 1984. Calcium-phosphate ceramics, in: Metal and Ceramic Biomaterials, Vol. II, Strength and Surface (P. Ducheyne, G.W. Hastings, eds.), pp. 143–166, CRC Press, Boca Raton.

    Google Scholar 

  • Vermes, I., Haanen, C, Steffen-Nakken, H., Reutelingsperger, C. 1995, A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V, J. Immunol. Methods 184, 39–51.

    Article  Google Scholar 

  • Vitale, M., Neri, L.M., Comani, S., Falcieri, E., Rizzoli, R., Rana, R., Papa, S. 1989. Natural killer function in flow cytometry. II. Evaluation of NK lytic activity by means of target cell morphological changes detected by right angle light scatter, J. Immunol. Methods 121, 115–120.

    Article  Google Scholar 

  • Vroman, L., Adams, A.L., Brakman, M. 1985. Lack of exchange among plasma proteins in narrow spaces on glass, demonstrated with metal oxide coatings, Haemostasis 15, 300–303.

    Google Scholar 

  • Wagner, M., Klein, C.L., van Kooten, T.G., Kirkpatrick, C.J. 1998. Mechanisms of cell activation by heavy metal ions, J. Biomed. Mater. Res. 42, 443–452.

    Article  Google Scholar 

  • Walivaara, B., Askendal, A., Krozer, A., Lundstrom, I., Tengvall, P. 1996. Blood protein interactions with chromium surfaces, J. Biomater. Sci., Polym. Ed. 81, 49–62.

    Google Scholar 

  • Wang, J.S., Goodman, S., Aspenberg, P. 1994. Bone formation in the presence of phagocytosable hydroxyapatite particles, Clin Orthop. 304, 272–279.

    Google Scholar 

  • Wang, J.Y., Tsukayama, D.T., Wicklund, B.H., Gustilo, R.B. 1996. Inhibition of T and B cell proliferation by titanium, cobalt, and chromium: role of IL-2 and IL-6, J. Biomed. Mater. Res. 32, 655–661.

    Article  Google Scholar 

  • Wang, J.Y., Wicklund, B.H., Gustilo, R.B., Tsukayama D.T. 1997a. Prosthetic metals impair murine immune response and cytokine release in vivo and in vitro, J. Orthop. Res. 15, 688–699.

    Article  Google Scholar 

  • Wang, W., Ferguson, D.J., Quinn, J.M., Simpson, A.H., Athanasou, N.A. 1997b. Biomaterial particle phagocytosis by bone-resorbing osteoclasts, J. Bone Jt. Surg., Br. Vol. 79, 849–856.

    Google Scholar 

  • Williams, D.F. 1982. Tissue reaction to metallic corrosion products and wear particles in clinical orthopaedics, in: Biocompatibility of Orthopaedic Implants, Vol. I (D.F. Williams, ed.), CRC Press, Inc., Boca Raton.

    Google Scholar 

  • Williams, D.F., Black, J., Doherty, P.J. 1993. Second consensus conference on definitions in biomaterials, in: Biomaterial-Tissue Interfaces: Advances in Biomaterials, Vol 107 (P.J. Doherty, D.F. Williams, eds.), pp. 525–533, Elsevier Applied Science, London.

    Google Scholar 

  • Winter, G.D. 1974. Tissue reactions to metallic wear and corrosion products in human patients, J. Biomed. Mater. Res. 5, 11–26.

    Google Scholar 

  • Wooley, P.H., Nasser, S., Fitzgerald, R.H. Jr. 1996. The immune response to implant materials in humans, Clin. Orthop. 326, 63–70.

    Google Scholar 

  • Wooley, P.H., Petersen, S., Song, Z., Nasser, S. 1997. Cellular immune response to orthopedic implant materials following cemented total joint replacement, J. Orthop. Res. 15, 874–880.

    Article  Google Scholar 

  • Wuyts, P., Proost, W., Put, J., Lenaerts, P., Paemen, L., Van Damme, J. 1994. Leukocyte recruitment by monocyte chemotactic proteins (MCPs) secreted by human phagocytes, J. Immunol. Methods 174, 237–247.

    Article  Google Scholar 

  • Yamaji, K., Yamane, S., Niimi, Y., Sueoka, A., Nose, Y. 1997. Strategy of leukocyte filtration for immunomodulation: development of stainless steel leukocyte filter, Ther. Apher. 1, 63–66.

    Google Scholar 

  • Yang, J., Merritt, K. 1994. Detection of antibodies against corrosion products in patients after Co-Cr total joint replacements, J. Biomed. Mater. Res. 28, 1249–1258.

    Article  Google Scholar 

  • Yang, J., Merritt, K. 1996. Production of monoclonal antibodies to study corrosion products of CoCr biomaterials, J. Biomed. Mater. Res. 31, 71–80.

    Google Scholar 

  • Zigmond, S.H., Hirsch, J.G. 1973. Leukocyte locomotion and chemotaxis. New method for evaluation, and demonstration of a cell-derived chemotactic factor, J. Exp. Med. 137, 387–410.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy

    Arturo Pizzoferrato, Elisabetta Cenni, Gabriela Ciapetti, Donatella Granchi, Lucia Savarino & Susanna Stea

Authors
  1. Arturo Pizzoferrato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elisabetta Cenni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gabriela Ciapetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Donatella Granchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lucia Savarino
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Susanna Stea
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Interuniversity Research Center for Advanced Medical Systems (C.R.I.S.M.A.) Department of Chemical and Biosystem Sciences and Technologies, University of Siena, Siena, Italy

    Rolando Barbucci

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Pizzoferrato, A., Cenni, E., Ciapetti, G., Granchi, D., Savarino, L., Stea, S. (2002). Inflammatory Response to Metals and Ceramics. In: Barbucci, R. (eds) Integrated Biomaterials Science. Springer, Boston, MA. https://doi.org/10.1007/0-306-47583-9_26

Download citation

  • DOI: https://doi.org/10.1007/0-306-47583-9_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46678-6

  • Online ISBN: 978-0-306-47583-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation