Skip to main content
SpringerLink
Log in

Effect of Tea Polyphenols on Degranulation in Human Mature Basophils Differentiated with IL-4

  • Chapter
Animal Cell Technology: Challenges for the 21st Century

  • 223 Accesses

Abstract

We examined the effects of tea polyphenols on the activation process of human mature basophils by stimulation with Ca2+ ionophore A23187 or IgE receptor crosslinking. IL-4 was used to induce differentiation in human leukemia cell line KU812 into the morphological and functional human mature basophils used in this study. Among the tea polyphenols examined, (−)-epicatechin gallate (ECG) and (−)- epigallocatechin gallate (EGCG) inhibited degranulation caused by IgE receptor crosslinking as well as by A23187. Thus, our findings suggest that the effects of ECG and EGCG may act on signaling pathway which regulates degranulation in human basophils after the increase of intracellular Ca2+ concentration.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Daeron. M. (1997) Annu. Rev. Immunol. 15, 203–234.

    Article  PubMed  CAS  Google Scholar 

  2. Beaven, M. A,, and Metzger, H. (1993) Immunol. Today 14, 222–226.

    Article  PubMed  CAS  Google Scholar 

  3. Schroeder, J. T., Kagey-Sobotka, A,, and Lichtenstein, L. M. (1995) Allergy 50, 463–472.

    PubMed  CAS  Google Scholar 

  4. Beaven. M. A., Rogers, J., Moore, J. P., Hesketh, T. R., Smith, G. A,, and Metcalfe, J. C. (1984) J. Biol. Chem. 259, 7129–7136.

    PubMed  CAS  Google Scholar 

  5. Teshima. R., Saito, Y., Ikebuchi, H., Rajiva De Silva, N., Morita, Y., Nakanishi, M., Sawada, J., and Kitani, S. (1997) J. Immunol. 159, 964–969.

    PubMed  CAS  Google Scholar 

  6. Matsuo, N., Yamada, K., Yamashita, K., Shoji, K., Mori, M., and Sugano. M. (1996) In Vitro Cell. Dev. Biol. 32, 340–344.

    CAS  Google Scholar 

  7. Matsuo, N., Yamada, K., Shoji. K., Mori, M., and Sugano, M. (1996) Allergy 52, 58–64.

    Google Scholar 

  8. Igarashi. Y., Kurosawa, M., Ishikawa, O., Miyachi, Y., Sailo, H., Ebisawa, M., Iikura. Y., M., Uzumaki, H., and Nakahata. T.(1996) Clin. Exp. Allergy 26, 597–602.

    Article  PubMed  CAS  Google Scholar 

  9. Butchers. P. R., Fullartton. J. R., Skidmore, I. F., Thomson, L. E., Vardey, C. J., and Wheeldon, A. (1979) Br. J. Pharmacol. 67, 23–32.

    PubMed  CAS  Google Scholar 

  10. Kishi, K. (1985) Leuk. Res. 9, 381–390.

    Article  PubMed  CAS  Google Scholar 

  11. Gauchat, J-F., Henchoz, S., Mazzei, G., Aubry, J. P., Brunner, T., Blasey, H., Life, P., Talabot, D.: Flores-Romo, L., Thompson, J., Kishi, K., Butterfield, J., Dahinden, C., and Bonnefoy, J-Y. (1993) Nature 365; 340–343.

    Article  PubMed  CAS  Google Scholar 

  12. Hara. T., Yamada, K., and Tachibana, H. (1998) Biochem. Biophys. Res. Commun. 247, 542–548.

    Article  PubMed  CAS  Google Scholar 

  13. Lindau, M., and Gomperts, B. D. (1991) Biochem. Biophys. Acta 1071, 429–471.

    PubMed  CAS  Google Scholar 

  14. Das, N. P. (1971) Biochem. Pharmacol. 20, 3435–3445.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate School of Bioresources and Bioenviromental Scieince, Kyushu University, Hakozuki 6-10-1, Fukuoka, 812-8581, Japan

    Hirofumi Tachibana, Yousuke Sunada & Takashi Hara

Authors
  1. Hirofumi Tachibana
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yousuke Sunada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takashi Hara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Koji Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Kouji Ikura Masaya Nagao Seiji Masuda Ryuzo Sasaki

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Tachibana, H., Sunada, Y., Hara, T., Yamada, K. (2002). Effect of Tea Polyphenols on Degranulation in Human Mature Basophils Differentiated with IL-4. In: Ikura, K., Nagao, M., Masuda, S., Sasaki, R. (eds) Animal Cell Technology: Challenges for the 21st Century. Springer, Dordrecht. https://doi.org/10.1007/0-306-46869-7_53

Download citation

  • DOI: https://doi.org/10.1007/0-306-46869-7_53

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-5805-3

  • Online ISBN: 978-0-306-46869-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation