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The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally

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Abstract

Glatiramer acetate (GA) significantly ameliorates multiple sclerosis and was initially discovered through its effects on the animal model experimental autoimmune encephalomyelitis (EAE). Guillain-Barré syndrome (GBS) is a relatively common demyelinating disease of peripheral nerves for which there is a parallel animal model, experimental autoimmune neuritis (EAN). We review the treatments found useful in EAN with special emphasis on the need for quick onset of action and the relevance of treatments used for EAE and multiple sclerosis. We evaluated the effect of GA administered by a novel intraperitoneal route in EAN. GA significantly ameliorated the severity of disease in rats (F = 6.3, p = 0.01 by analysis of variance (ANOVA)) and course of disease (F = 4.9, p = 0.02 by repeated-measures ANOVA with a day × treatment interaction term). Neurophysiology data supported the trend for the beneficial effect of GA. Myelin-induced immune cell proliferation was significantly modulated by GA (p < 0.025). This report describes a novel route of administration of GA and a rapid beneficial effect of GA in EAN. GA may be useful in human diseases, such as GBS, where the intravenous route may offer a rapid onset of drug action.

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Acknowledgments

The study was supported by a grant from Teva Pharmaceuticals. We thank Dr. Liat Hayardeni for her very helpful critical discussion and review of the manuscript.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel

    Ramona Aronovich & Joab Chapman

  2. Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

    Joab Chapman

  3. Department of Neurology and Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel

    Aviva Katzav & Joab Chapman

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  1. Ramona Aronovich
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  2. Aviva Katzav
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  3. Joab Chapman
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Correspondence to Joab Chapman.

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Ramona Aronovich and Aviva Katzav contributed equally to this study.

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Aronovich, R., Katzav, A. & Chapman, J. The Strategies Used for Treatment of Experimental Autoimmune Neuritis (EAN): A Beneficial Effect of Glatiramer Acetate Administered Intraperitoneally. Clinic Rev Allerg Immunol 42, 181–188 (2012). https://doi.org/10.1007/s12016-010-8246-7

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