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Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran

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Abstract

The increase in the prevalence of antibiotic resistance in Helicobacter pylori had a drastic effect on successful treatment. Up-to-date information on H. pylori antibiotic therapy in Iran is still limited. In this study, we aim to determine the prevalence of antibiotic resistance among the H. pylori strains. Furthermore, the possibility of using fluoroquinolones for antibiotic treatment was investigated. Antral biopsy specimens obtained from dyspeptic patients were investigated for H. pylori. Bacterial culture and susceptibility tests were done based on standard methods. H. pylori ATCC 43504 was used as a quality control. In the current study, 30 H. pylori strains were selected randomly and retested to confirm our susceptibility tests. Of 170 patients, 150 were identified as positive for H. pylori (88.2%). In this study, 150 single colonies of H. pylori strains [81 women (54%), 69 men (46%); mean age 38.6; aged 21–70 years] were collected. Primary resistance of H. pylori isolates were clarithromycin (34%), metronidazole (78.6%), tetracycline (9.3%), amoxicillin (10%), levofloxacin (5.3%) and moxifloxacine (4.6%). In conclusion, our results show that we are confronting a new generation of resistant strains of H. pylori in Iran. This alarming finding indicates an urgent need for introduction of new effective antibiotics in our country. Since the majority of clinicians prefer to continue with the ineffective antibiotics as therapeutic regimens, they must also be prepared to deal with treatment failures.

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Acknowledgments

This project was supported financially by M Sc thesis at Tarbiat Modares University at 2007.

Conflict of interest

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Authors and Affiliations

  1. Department of Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Amin Talebi Bezmin Abadi & Ashraf Mohabbati Mobarez

  2. Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA

    Ali Ghasemzadeh

  3. Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Tarang Taghvaei

  4. Endoscopic Room, Tooba Clinic, Khazar Blv, Sari, Mazandaran, Iran

    Tarang Taghvaei

Authors
  1. Amin Talebi Bezmin Abadi
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  2. Ali Ghasemzadeh
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  3. Tarang Taghvaei
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  4. Ashraf Mohabbati Mobarez
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Correspondence to Tarang Taghvaei.

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Talebi Bezmin Abadi, A., Ghasemzadeh, A., Taghvaei, T. et al. Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran. Intern Emerg Med 7, 447–452 (2012). https://doi.org/10.1007/s11739-011-0563-1

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  • DOI: https://doi.org/10.1007/s11739-011-0563-1

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