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Are biomarkers correlated with recurrence patterns in patients with resectable gastric adenocarcinoma

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Abstract

The aims of this study are to analyze the failure patterns in radical resected gastric adenocarcinoma, and to evaluate the correlation between recurrence patterns and potentially prognostic factors, including clinical pathological characteristic and biomarkers. Between Jan 2004 and Jun 2006, 84 patients were enrolled into the database analysis, including 8 with clinical stage I, 20 with clinical stage II, 21 with clinical stage IIIA, 22 with clinical stage IIIB and 13 with clinical stage IV, male 61 and female 23. The collected biomarkers including: preoperative tumor markers: CEA, AFP, CA199, CA50, CA72-4 and CA24-2; postoperative immunohistochemical (IHC) markers: Bax, Bcl-2, P27, CyclinD1, TOPO2, MDR, GST-π, Ki67, epidermal growth factor receptor (EGFR), P21, P53, proliferating cell nuclear antigen (PCNA), C-myc and Neu. Three-year local control rate (LCR), disease-free survival (DFS) and over-all survival (OS) were 66, 61 and 64% respectively. Logistic regression analysis showed cyclinD1 and CEA were correlated with prognosis; cyclinD1, CEA were correlated with loco-regional recurrence; PCNA was correlated with remote metastasis; bcl-2, ki67, c-myc2 and Neu were correlated with lymph node metastasis. The present study indicate that patterns of recurrence are variable and may be associated with specific biomarkers, in addition, high level of CEA and low-expressed of cyclinD1 resulted in poor prognosis.

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Authors and Affiliations

  1. Department of Radiation Oncology, Shanghai Cancer Center, Fudan University, 270 Dong-an Road, Shanghai, 200032, People’s Republic of China

    Gui-Chao Li, Zhen Zhang & Xue-Jun Ma

  2. Department of Abdominal Surgery, Shanghai Cancer Center, Fudan University, 270 Dong-an Road, Shanghai, 200032, People’s Republic of China

    Wei-Lie Gu & Ya-Nong Wang

  3. Department of Medical Oncology, Gastric Cancer Multidisciplinary Treatment Group, Shanghai Cancer Center, Fudan University, 270 Dong-an Road, Shanghai, 200032, People’s Republic of China

    Jin Li

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  1. Gui-Chao Li
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  2. Zhen Zhang
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  4. Wei-Lie Gu
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  6. Jin Li
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Correspondence to Zhen Zhang.

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We declare that out study has not been supported by any Commercial Sponsorship.

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Li, GC., Zhang, Z., Ma, XJ. et al. Are biomarkers correlated with recurrence patterns in patients with resectable gastric adenocarcinoma. Mol Biol Rep 39, 399–405 (2012). https://doi.org/10.1007/s11033-011-0751-0

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  • DOI: https://doi.org/10.1007/s11033-011-0751-0

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