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Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy

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Abstract

Amino-functionalized superparamagnetic iron oxide nanoparticles (SPION) were synthesized by coprecipitation method. The particles were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron micrographs (SEM), transmission electron micrographs (TEM) and atomic force micrographs (AFM). The size of the modified particles varied in the range 10–15 nm and did not change significantly after modification. Hepama-1, an excellent humanized monoclonal antibody directed against liver cancer, was conjugated to the SPION to prepare immuno-magnetic nanoparticles (IMN). A direct labeling method was employed to radiolabel IMN with rhenium-188. The radiolabeling efficiency was about 90% with good in vitro stability. 188Re labeled IMN could markedly kill SMMC-7721 liver cancer cells. Such SPION might be very useful for bio-magnetically targeted radiotherapy in liver cancer treatment.

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References

  1. C. E. SJÖGREN, C. JOHANSSON, A. NAVESTAD, P. C. SONTUM, K. B. SABO and A. K. FAHLVIK, Magn. Reson. Imaging. 15 (1997) 55

    Article  Google Scholar 

  2. J. ROGER, J. PONS, R. MASSART, A. HALBREICH and J. BACRI, J. Appl. Phys. 5 (1999) 321

    CAS  Google Scholar 

  3. D. K. KIM, Y. ZHANG, W. VOIT, K. V. RAO, J. KEHR and B. BJELK, Sci. Mater. 44 (2001) 1713

    CAS  Google Scholar 

  4. D. K. KIM, M. MIKHAYLOVA, Y. ZHANG and M. MUHAMMED, Chem. Mater. 15 (2003) 1617

    Article  CAS  Google Scholar 

  5. D. K. KIM, Ph.D. Thesis. Royal Institute of Technology, Stockholm (2002)

  6. K. J. WIDDER, R. M. MORRIS, G. A. POORE, D. P. HOWARD and A. E. SENYEI, Eur. J. Cancer Clin. Oncol. 19 (1983) 135

    Article  CAS  Google Scholar 

  7. K. J. WIDDER, P. A. MARINO, R. M. MORRIS, D. P. HOWARD, G. A. POORE and A. E. SENYEI, Eur. J. Cancer Clin. Oncol. 19 (1983) 141

    Article  CAS  Google Scholar 

  8. K. J. WIDDER and A. E. SENYEI, Pharmacol. Ther. 20 (1983) 377

    Article  CAS  Google Scholar 

  9. M. RETTENMAIER, J. STRATTON, P. DISAIA, M. BERMAN, A. SENYEI and K. WIDDER, Gynecol. Oncol. 20 (1985) 268

    Article  Google Scholar 

  10. V. W. LIN, I. HSIAO, D. GOODWIN and I. PERKASHE, Arch. Phys. Med. Rehabil. 82 (2001) 969

    Article  CAS  Google Scholar 

  11. C. ALEXIOU, W. ARNOLD, P. HULIN, R. J. KLEIN, H. RENZ, F. G. PARAK, C. BERGEMANN and A. S. LÜBBE, J. Magnetism Magn. Mater. 225 (2001) 187

    Article  CAS  Google Scholar 

  12. J. F. YU, U. O. HÄFELI, M. SANDS and Y. Dong, Appl. Radiat. Isot. 58 (2003) 567

    Article  CAS  Google Scholar 

  13. U. O. HÄFELI, W. K. ROBERTS, G. J. PAUER, S. K. KRAEFT and R. M. MACKLIS, Appl. Radiat. Isot. 54 (2001) 869

    Article  Google Scholar 

  14. U. HÄFELI, G. PAUER, S. FAILING and G. TAPOLSKY, J. Magnetism Magn. Mater. 225 (2001) 73

    Article  Google Scholar 

  15. W. K. ROBERTS and U. O. HÄFELI, Appl. Radiat. Isot. 51 (1999) 543

    Article  CAS  Google Scholar 

  16. U. O. HÄFELI, S. M. SWEENEY, B. A. BERESFORD, J. L. HUMM and R. M. MACKLIS, Nucl. Med. Biol. 22 (1995) 147

    Article  Google Scholar 

  17. U. O. HÄFELI and G. J. PAUER, J. Magnetism Magn. Mater. 194 (1999) 76

    Article  Google Scholar 

  18. G. L. GRIFFITHS, D. M. GOLDENBERG, F. KNAPP, A. P. CALLAHAN, Ch. CHANG and H. J. HANSEN, Cancer Res. 51 (1991) 4594

    CAS  Google Scholar 

  19. T. MOSSMAN, J. Immunol. Methods 65 (1983) 55

    Article  Google Scholar 

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Acknowledgments

The research program was supported by National Natural Science Foundation of China (Grant No. 10405034 and 20501022) and the Knowledge Innovation Project of Chinese Academy of Sciences (Grant No. JCXI-SW-08).

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Authors and Affiliations

  1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 2019 Jialuo Road, Shanghai, 201800, P.R. China

    Sheng Liang, Yongxian Wang, Junfeng Yu, Chunfu Zhang, Jiaoyun Xia & Duanzhi Yin

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  1. Sheng Liang
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  2. Yongxian Wang
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  3. Junfeng Yu
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  4. Chunfu Zhang
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  6. Duanzhi Yin
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Correspondence to Sheng Liang.

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Liang, S., Wang, Y., Yu, J. et al. Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy. J Mater Sci: Mater Med 18, 2297–2302 (2007). https://doi.org/10.1007/s10856-007-3130-6

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