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Immune Dysregulation in Patients with Severe Acute Pancreatitis

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Abstract

To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-4 (IL-4) were determined on admission and days 3, 7, and 14. For comparison, patients were analyzed through infection group versus non-infection group, multiple organ dysfunction syndrome (MODS) group versus non-MODS group. There were sixteen patients with secondary infection, twenty-two with MODS, and nine deaths. The infection group had higher levels of ET than the non-infection group on days 3 and 7. The dynamic cytokine levels of patients in the MODS group were unanimous with those outcomes in the infection group. The levels of cytokines in the infection group were different from the non-infection group, with more levels of TNF-α, IL-6 on days 3 and 7 and less on days 14, and more levels of IL-10, IL-4 on days7 and 14. The levels of TNF-α, IL-6 in the MODS group were different from the non-MODS group, with more levels on days 3 and 7, and less levels on days 14. Immune dysregulation may play an important role in infection and organ dysfunction for patients with SAP.

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Acknowledgment

This work was supported by the National Science and Technology Support Program of China (grant no. 2006BAI04A15). We thank all the volunteers.

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Authors and Affiliations

  1. National Medical Center of Biliopancreatic Diseases, Nankai Hospital, Nankai Clinical School, Tianjin Medical University, Tianjin, People’s Republic of China

    YinFeng Shen, NaiQiang Cui, Bing Miao & ErPeng Zhao

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  1. YinFeng Shen
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  2. NaiQiang Cui
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  3. Bing Miao
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  4. ErPeng Zhao
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Correspondence to NaiQiang Cui.

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None of the authors have identified a conflict of interest, and the material was not presented at any annual meetings and journals.

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Shen, Y., Cui, N., Miao, B. et al. Immune Dysregulation in Patients with Severe Acute Pancreatitis. Inflammation 34, 36–42 (2011). https://doi.org/10.1007/s10753-010-9205-4

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