Skip to main content

Advertisement

Log in

Increased expression of tumor necrosis factor-α messenger RNA in the intestinal mucosa of inflammatory bowel disease, particularly in patients with disease in the inactive phase

  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Background:

Background:

Tumor necrosis factor-α (TNF-α), may be involved in the pathogenesis of inflammatory bowel diseases (IBDs). The aim of this study was to evaluate the effect of TNF-α on the inflammatory activity of IBD.

Methods:

TNF-α mRNA expression in intestinal mucosal biopsy specimens from IBD patients [ulcerative colitis (UC), n= 54; and Crohn's disease (CD), n= 11] was analyzed using a competitive polymerase chain reaction. The degree of macrophage infiltration was analyzed by immunohistochemistry, using an anti-human CD68 antibody.

Results:

TNF-α mRNA expression was increased in UC patients, corresponding to the inflammatory activity. However, in CD, TNF-α mRNA expression was not correlated with the endoscopic findings.

Conclusions:

We clarified that TNF-α mRNA expression was responsible for the inflammatory activity in UC. However, TNF-α mRNA expression was not correlated with the mucosal injury in CD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: February 9, 2001 / Accepted: September 28, 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akazawa, A., Sakaida, I., Higaki, S. et al. Increased expression of tumor necrosis factor-α messenger RNA in the intestinal mucosa of inflammatory bowel disease, particularly in patients with disease in the inactive phase. J Gastroenterol 37, 345–353 (2002). https://doi.org/10.1007/s005350200048

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s005350200048

Navigation