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Surfactant Lavage with Lidocaine Improves Pulmonary Function in Piglets after HCl-Induced Acute Lung Injury

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Abstract

Acute respiratory distress syndrome (ARDS) is associated with significant morbidity and mortality. The pathophysiology of ARDS includes abnormalities of surfactant function as well as pulmonary inflammation. Immunomodulating drugs, like Lidocaine, have shown some success in decreasing inflammation in ARDS. We attempted to combine surfactant lavage’s ability to reverse the surfactant dysfunction, while acting as a vehicle to deliver Lidocaine. Gravity-driven surfactant (Infasurf) lavage (35 ml/kg) was administered alone or mixed with Lidocaine after severe HCl acid injury (0.3 N; 3 cc/kg) in neonatal piglets. Treatment groups included: control (C) (n = 5), surfactant lavage (SL) (35 ml/kg-diluted Infasurf) (n = 7) and SL mixed with Lidocaine (SL+L) (n = 7). About 26–27% of the lavage was retained (phospholipid 73–74 mg/kg; Lidocaine 1.8 mg/kg). Oxygenation progressively increased in the SL and SL+L groups over the 4-hour period (at 240 min: C = 99 ± 14; SL = 154 ± 39; SL+L = 230 ± 40 mmHg) (p < 0.05). PaCO2 increased in all groups from 43 ± 0.3 to 55 ± 0.7 mmHg. Only SL+L showed a reduction in PaCO2 (at 240 min: C = 54 ± 4; SL = 53 ± 7; SL+L = 49 ± 2 mmHg) (p < 0.05). Finally, SL and SL + L had superior characteristics during the quasi-static pressure volume (PV) procedure as compared to Control (p < 0.05). In our HCl ALI model, SL improved oxygenation and quasi-static lung compliance over C. The pulmonary function effects of SL were further enhanced by the addition of Lidocaine to the surfactant suspension. Combining therapeutic agents with surfactant lavage may be an effective strategy in ALI.

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Acknowledgements

We thank the Dept. of Clinical Investigation for the use of their facilities and technical support, Ony Inc, for donating Infasurf surfactant, Dr Karen Thompson, Dept of Pathology, Kapiolani MC for her assistance in scoring the pathology specimens, and Dr. Timothy Haley, Tripler Army Medical Center for technical help and assistance with the experiments. Supported in part by NIH-RCMI, P20RR/11091, Advancing Newborn Medicine Fellowship Grant by Forest, Pharmaceuticals, Inc., Kapi’olani Children’s Miracle Network, and the Leahi Hawaii Community Foundation, Honolulu, HI. Infasurf donated by ONY, Inc, New York.

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Authors and Affiliations

  1. Department of Clinical Investigation, Tripler Army Medical Center, TAMC, Honolulu, Hawaii 96826, USA

    T. K. Huang, C. F. T. Uyehara, C. Y. Miyasato, D. Person & D. Easa

  2. Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii and Kapiolani Medical Center, Honolulu, Hawaii 96826, USA

    V. Balaraman

  3. Department of Pediatrics and Physiology, University of Buffalo, State University of New York, Buffalo, New York, USA

    E. Egan

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  1. T. K. Huang
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Correspondence to D. Easa.

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Huang, T., Uyehara, C., Balaraman, V. et al. Surfactant Lavage with Lidocaine Improves Pulmonary Function in Piglets after HCl-Induced Acute Lung Injury . Lung 182, 15–25 (2004). https://doi.org/10.1007/s00408-003-1041-y

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