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Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris

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Abstract

Nuclear factor kappa-beta (NF-κB) is a critical transcription factor modulating the expression of many genes involved in the pathogenesis of psoriasis. SUMO4 is a negative regulator of NF-κB in the cell-signaling pathway. Two functional polymorphisms of the NFKB1 and SUMO4 genes have been found to be associated with the risks of some autoimmune-related diseases, but no published study has investigated the role of these polymorphisms in the etiology of psoriasis in the Chinese population. In this hospital-based, case–control study of 519 Chinese psoriasis vulgaris patients and 541 matched controls, we genotyped the NFKB1-94 ins/delATTG and the SUMO4 rs237025 A>G polymorphisms and assessed their respective associations with psoriasis vulgaris risk. We found that the genotype distribution of NFKB1-94 ins/delATTG polymorphism was statistically different between psoriasis patients and controls (P = 0.031). But the difference was not still statistically significant after correction for multiple comparisons. The frequency of wild WW genotype in psoriasis patients was statistically higher than that in controls (35.8 vs. 29.0%, respectively, P = 0.021). The W allele frequency in cases was also significantly higher than that in controls (59.7 vs. 54.1%, P = 0.008). Compared with the DD genotype, a significantly increased psoriasis risk was associated with the NFKB1 WW genotype (adjusted OR = 1.57, 95% CI = 1.10–2.24). In addition, the WW genotype frequency was also statistically higher in the psoriatic subgroups of onset age ≤40, PASI >20, male patients and sporadic patients than that in controls. But, no associations of the SUMO4 rs237025 A>G polymorphism with the susceptibility of psoriasis were detected. In conclusion, we found a marginal association between the NFKB1-94 ins/delATTG WW genotype and the increased psoriasis vulgaris risk and the association was more evident in the subgroups of onset age ≤40, PASI >20, male patients and sporadic patients in Chinese.

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Abbreviations

NF-κB:

Nuclear factor kappa-B

IκB:

Inhibitor-kappa

SUMO:

Small ubiquitin-related modifier

SNP:

Single nucleotide polymorphisms

PASI:

Psoriasis area and severity index

PCR:

Polymerase chain reaction

RFLP:

Restriction fragment length polymorphism

OR:

Odds ratio

CI:

Confidence interval

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Authors and Affiliations

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 710032, Xi’an, China

    Hong Li, Lin Gao, Zhu Shen, Chun Ying Li, Kai Li, Miao Li, Ya Jie Lv, Cheng Xin Li, Tian Wen Gao & Yu Feng Liu

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  1. Hong Li
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  2. Lin Gao
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  3. Zhu Shen
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Correspondence to Yu Feng Liu.

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H. Li, L. Gao and Z. Shen should be considered co-first authors.

Grant support: National Natural Science Foundation of China (No.30600558 and 30330510).

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Li, H., Gao, L., Shen, Z. et al. Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris. Arch Dermatol Res 300, 425–433 (2008). https://doi.org/10.1007/s00403-008-0843-4

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  • DOI: https://doi.org/10.1007/s00403-008-0843-4

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