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Rare primary extranodal lymphomas: diffuse large B-cell lymphomas of the genital tract

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Abstract

Primary non-Hodgkin’s lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of uterine lymphoma and one case of prostate lymphoma in this paper. The symptoms and the differential diagnosis are also discussed. Because of the low incidence, there is no widely accepted consensus on its treatment. We demonstrate that the rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone; R-CHOP) chemoimmunotherapy is a good and tolerable treatment option in all cases. The two young patients are disease-free nowadays; the older patient with poor prognostic histological-type lymphoma relapsed in a short time and died after second relapse. A multicenter analysis is necessary to evaluate the long-term results of chemoimmunotherapy in these rare extranodal lymphoma entities.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Hematology, Kaposi Mór Teaching Hospital, Tallián Gy. str. 20-32, 7400, Kaposvár, Hungary

    Péter Rajnics, Balázs Kollár, Zsuzsanna Kertész & Miklós Egyed

  2. First Department of Internal Medicine, Division of Hematology, Semmelweis University of Budapest, Budapest, Hungary

    Judit Demeter

  3. Department of Pathology, St. László Hospital, Budapest, Hungary

    Judit Csomor

  4. Laboratory of Tumor Pathology and Molecular Diagnostics, Institute of Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary

    László Krenács

  5. Department of Pathology, University of Pécs, Pécs, Hungary

    László Pajor

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  1. Péter Rajnics
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Rajnics, P., Demeter, J., Csomor, J. et al. Rare primary extranodal lymphomas: diffuse large B-cell lymphomas of the genital tract. Ann Hematol 88, 1223–1228 (2009). https://doi.org/10.1007/s00277-009-0741-7

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