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Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks

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Abstract

We retrospectively reviewed 107 patients with 108 malignant or locally aggressive bone tumours treated between 1978 and 2009 by extracorporeal irradiation with 300 Gy to eradicate the tumour, and reimplantation of the bone as an orthotopic autograft. Patient subgroups were defined according to resection type. We describe the local recurrence rate, the graft infection rate and the factors affecting graft healing and graft survival. No local recurrences were detected in the irradiated grafts. At five-year follow-up, graft healing had occurred in 64% of patients, providing a stable and lasting reconstruction. For various reasons, 11% of grafts were removed, although no single factor was predictive of failure. All patient subgroups had comparable results. Early infection predicted the development of pseudarthrosis. Pelvic reconstructions had a worse graft survival. Rigid fixation and bridging of the graft appeared to be important technical points.

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Acknowledgments

The authors wish to thank Githa Gillis for record keeping.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium

    Bart Poffyn, Gwen Sys, Alexander Mulliez & Dirk Uyttendaele

  2. Department of Public Health, Ghent University, Gent, Belgium

    Georges Van Maele

  3. Department of Subatomic and Radiation Physics, Ghent University, Gent, Belgium

    Luc Van Hoorebeke

  4. N. Goormaghtigh Institute of Pathology, Ghent University Hospital, Gent, Belgium

    Ramses Forsyth

Authors
  1. Bart Poffyn
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  2. Gwen Sys
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  3. Alexander Mulliez
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  4. Georges Van Maele
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  5. Luc Van Hoorebeke
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  6. Ramses Forsyth
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  7. Dirk Uyttendaele
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Corresponding author

Correspondence to Gwen Sys.

Additional information

The Departments of Orthopaedic Surgery and Pathology are partners of the EuroBoNet consortium, a European Commission-granted Network of Excellence for studying the pathology and genetics of bone tumours.

This study was approved on 27 November 2007 by the Ethics Committee of the Ghent University Hospital. Work was performed at the Ghent University Hospital and Ghent University.

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Poffyn, B., Sys, G., Mulliez, A. et al. Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks. International Orthopaedics (SICOT) 35, 889–895 (2011). https://doi.org/10.1007/s00264-010-1098-1

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  • DOI: https://doi.org/10.1007/s00264-010-1098-1

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