Abstract
We present a case of a subcutaneous encapsulated fat necrosis of the upper extremity that mimicked subcutaneous liposarcoma because of heterogeneous signal intensity, its relatively large size, and pronounced enhancement on magnetic resonance imaging (MRI). For this case, we present the radiologic findings including MRI, positron emission tomography-computed tomography (PET-CT), ultrasonography, and radiography. We emphasize the imaging features of this lesion, which has a fibrous capsule and briefly discuss its nomenclature and pathophysiology.
References
Hurt MA, Santa Cruz DJ. Nodular-cystic fat necrosis. A reevaluation of the so-called mobile encapsulated lipoma. J Am Acad Dermatol. 1989;21(3 Pt 1):493–8.
Schmidt-Hermes HJ, Loskant G. Calcified fat necrosis of the female breast. Med Welt. 1975;26(24):1179–80.
Canteli B, Saez F, de los Rios A, Alvarez C. Fat necrosis. Skelet Radiol. 1996;25(3):305–7.
Lopez JA, Saez F, Alejandro Larena J, Capelastegui A, Martin JI, Canteli B. MRI diagnosis and follow-up of subcutaneous fat necrosis. J Magn Reson Imaging: JMRI. 1997;7(5):929–32.
Walsh M, Jacobson JA, Kim SM, Lucas DR, Morag Y, Fessell DP. Sonography of fat necrosis involving the extremity and torso with magnetic resonance imaging and histologic correlation. J Ultrasound Med: Off J Am Inst Ultrasound Med. 2008;27(12):1751–7.
Przyjemski CJ, Schuster SR. Nodular-cystic fat necrosis. J Pediatr. 1977;91(4):605–7.
Kikuchi I, Okazaki M, Narahara S. The so-called mobile encapsulated lipoma. J Dermatol. 1984;11(4):410–2.
Sahl Jr WJ. Mobile encapsulated lipomas. Formerly called encapsulated angiolipomas. Arch Dermatol. 1978;114(11):1684–6.
Kikuchi I. Encapsulated necrosis on the legs showing a changing number of nodules. A special type of encapsulated adiponecrosis? J Dermatol. 1984;11(4):413–6.
Felipo F, Vaquero M, del Agua C. Pseudotumoral encapsulated fat necrosis with diffuse pseudomembranous degeneration. J Cutan Pathol. 2004;31(8):565–7.
Kiryu H, Rikihisa W, Furue M. Encapsulated fat necrosis—a clinicopathological study of 8 cases and a literature review. J Cutan Pathol. 2000;27(1):19–23.
Ohtake N, Gushi A, Matsushita S, Kanzaki T. Encapsulated fat necrosis in a patient with Ehlers-Danlos syndrome. J Cutan Pathol. 1997;24(3):189–92.
Takao H, Yamahira K, Watanabe T. Encapsulated fat necrosis mimicking abdominal liposarcoma: computed tomography findings. J Comput Assist Tomogr. 2004;28(2):193–4.
Yi-Hsin H, Ya-Wen H, Yi-Chin S. Multiple floating fat balls on the right lower leg. Nodular cystic fat necrosis. Indian J Dermatol Venereol Leprol. 2011;77(6):731–2.
Pujol RM, Wang CY, Gibson LE, Su WP. Lipomembranous changes in nodular-cystic fat necrosis. J Cutan Pathol. 1995;22(6):551–5.
Oh CW, Kim KH. A case of nodular cystic fat necrosis: the end stage lesion showing calcification and lipomembranous changes. J Dermatol. 1998;25(9):616–21.
Hanami Y, Hiraiwa T, Yamamoto T. Nodular cystic fat necrosis with calcification and metaplastic ossification. Am J Dermatopathol. 2012;34(7):782–4.
Brooke BS, Choti MA. Image of the month. Encapsulated fat necrosis. Arch Surg. 2011;146(12):1447–8.
Andac N, Baltacioglu F, Cimsit NC, Tuney D, Aktan O. Fat necrosis mimicking liposarcoma in a patient with pelvic lipomatosis. CT findings. Clin Imaging. 2003;27(2):109–11.
Adejolu M, Huo L, Rohren E, Santiago L, Yang WT. False-positive lesions mimicking breast cancer on FDG PET and PET/CT. AJR Am J Roentgenol. 2012;198(3):W304–14.
Belakhlef A, Jani C, Church C, Fraser R, Lakhanpal S. Fat necrosis mimicking B-cell lymphoma: a PET/CT and FDG study. Clin Nucl Med. 2008;33(4):271–2.
Barile A, Zugaro L, Catalucci A, Caulo M, Di Cesare E, Splendiani A, et al. Soft tissue liposarcoma: histological subtypes, MRI and CT findings. Radiol Med. 2002;104(3):140–9.
El Ouni F, Jemni H, Trabelsi A, Ben Maitig M, Arifa N, Ben Rhouma K, et al. Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data. Orthop Traumatol Surg Res: OTSR. 2010;96(8):876–83.
Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics: Rev Publ Radiol Soc N Am Inc. 2005;25(5):1371–95.
Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics: Rev Publ Radiol Soc N Am Inc. 2004;24(5):1433–66.
Drevelegas A, Pilavaki M, Chourmouzi D. Lipomatous tumors of soft tissue: MR appearance with histological correlation. Eur J Radiol. 2004;50(3):257–67.
Toirkens J, De Schepper AM, Vanhoenacker F, Van Dyck P, Gielen J, Creytens D, et al. A comparison between histopathology and findings on magnetic resonance imaging of subcutaneous lipomatous soft-tissue tumors. Insights Imaging. 2011;2(5):599–607.
Bancroft LW, Kransdorf MJ, Peterson JJ, Sundaram M, Murphey MD, O'Connor MI. Imaging characteristics of spindle cell lipoma. AJR Am J Roentgenol. 2003;181(5):1251–4.
Bolen JW, Thorning D. Spindle-cell lipoma. A clinical, light- and electron-microscopical study. Am J Surg Pathol. 1981;5(5):435–41.
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Lee, S.A., Chung, H.W., Cho, K.J. et al. Encapsulated fat necrosis mimicking subcutaneous liposarcoma: radiologic findings on MR, PET-CT, and US imaging. Skeletal Radiol 42, 1465–1470 (2013). https://doi.org/10.1007/s00256-013-1647-y
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DOI: https://doi.org/10.1007/s00256-013-1647-y