Zusammenfassung
Die klinische Definition der Sepsis ist noch jung, hat sich aber trotz der wenig spezifischen Definition rasch zu einem wichtigen Konzept entwickelt. Das bessere Verständnis der wichtigen Maßnahmen zur Vermeidung von Organdysfunktionen hat erheblich zur Verbesserung der Prognose von Sepsispatienten beigetragen, auch wenn sich spezifische Eingriffe in den Entzündungsprozess bisher nicht als wirksam erwiesen haben. Die klinischen Zeichen der Sepsis sind wesentliche Charakteristika von schweren Infektionen. Im vorliegenden Beitrag wird das allgemeine und spezifische Management schwerer Infektionen, denen Kriterien der Sepsis gemeinsam sind, vorgestellt.
Abstract
The sepsis syndrome has only recently been defined as a clinical syndrome but despite its unspecific definition it has evolved rapidly into an important concept. Although specific therapeutic interventions targeting the inflammatory pathway have not yet been effective in treating sepsis, a better understanding of mechanisms leading to organ dysfunction has led to better management of patients with sepsis. Clinical signs of systemic inflammatory response syndrome (SIRS) or sepsis are hallmarks for the definition of severe infections. Current guidelines are presented for the management of a number of severe infectious syndromes.
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Salzberger, B., Hanses, F., Birkenfeld, G. et al. Schwere Infektionen. Internist 54, 925–935 (2013). https://doi.org/10.1007/s00108-012-3140-4
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DOI: https://doi.org/10.1007/s00108-012-3140-4
Schlüsselwörter
- „Systemic inflammatory response syndrome“
- Septischer Schock
- Clostridium difficile
- Bakterielle Meningitis
- Intraabdominale Infektionen