Zusammenfassung
Bei der EXIT-Prozedur („ex-utero intra-partum treatment“) erfolgt eine invasive Versorgung des Feten im Rahmen einer Sectio caesarea noch vor Unterbindung der Nabelschnur. Die Aufrechterhaltung der plazentaren Perfusion für die Dauer des Eingriffs erfordert ein spezielles anästhesiologisches und operatives Vorgehen. Berichtet wird der Fall einer 33-jährigen Patientin, bei der aufgrund eines großen Halstumors des Feten mit 36 Schwangerschaftswochen (SSW) eine EXIT-Prozedur in Allgemeinanästhesie zur kindlichen Atemwegssicherung durchgeführt wurde. Das anästhesiologische Vorgehen und die interdisziplinäre Aufgabenstellung werden im Kontext der Literaturdaten diskutiert.
Abstract
The ex-utero intra-partum (EXIT) procedure enables the surgeon to perform invasive procedures in an infant during cesarean section before clamping the umbilical cord. Specific anesthesiological concepts are necessary for ensuring sufficient umbilical perfusion. We report the case of a 33-year-old female undergoing cesarean section in the 36th week of pregnancy because of a large fetal cervical tumor. The EXIT procedure was performed in order to secure the infant’s airway during delivery. The anesthesiological management and interdisciplinary tasks are discussed in the literature review.
Literatur
Bealer JF, Skarsgard ED, Hedrick MH et al. (1995) The PLUG odyssey: adventures in experimental tracheal occlusion. J Pediatr Surg 30:361–365
Biehl DR, Yarnell R, Wade JG, Sitar D (1983) The uptake of isoflurane by the foetal lamb in utero: effect on regional blood flow. Can Anaesth Soc J 30:581–586
Bouchard S, Johnson MP, Flake AW et al. (2002) The EXIT procedure: experience and outcome in 31 cases. J Pediatr Surg 37:418–426
Cox PBW, Gogarten W, Stümper D, Marcus MAE (2004) Fetal surgery, anaesthesiological considerations. Curr Opin Anaesthesiol 17:235–240
Dahlgren G, Törnberg DC, Pregner K, Irestedt L (2004) Four cases of the EXIT procedure: anesthetic implications. Int J Obstet Anesth 13:178–182
Gaiser R, Kurth CD (1999) Anesthetic considerations for fetal surgery. Semin Perinatol 23:507–514
Gaiser R, Kurth CD, Cohen D, Crombleholme T (1999) The cesarean delivery of a twin gestation under 2 minimal alveolar anesthetic concentration isoflurane: one normal and one with a large neck mass. Anesth Analg 88:584–586
Gogarten W, Aken H van, Marcus MAE (2000) Fetal surgery: general or regional anaesthesia? Curr Opin Anaesthesiol 13:277–281
Harrison MR, Adzick NS, Flake AW et al. (1996) Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg 31:1339–1348
Hinrose S, Farmer DL, Lee H, Nobuhara KK, Harrison MR (2004) The ex utero intrapartum treatment procedure: looking back at the EXIT. J Pediatr Surg 39:375–380
Katz VL, Farmer RM (1999) Controversies in tocolytic therapy. Clin Obstet Gynecol 42:802–819
Leva E, Pansini L, Fava G, Maestri L, Pansini A, Selvaggio G (2005) The role of the surgeon in the case of a giant neck mass in the EXIT procedure. J Pediatr Surg 40:748–750
MacKenzie TC, Crombleholme TM, Flake AW (2002) The ex-utero intrapartum treatment. Curr Opin Pediatr 14:453–458
Mayer DC, Weeks SK (1992) Antepartum uterine relaxation with nitroglycerin at Cesarian delivery. Can J Anaesth 39:166–169
Mychaliska GB, Bealer JF, Rosen MA, Adzick NS, Harrison MR (1997) Operating on placental support: the ex utero intra partum procedure. J Pediatr Surg 32:227–231
Myers LB, Bulich LA, Mizrahi A et al. (2003) Ultrasonographic guidance for location of the trachea during the EXIT procedure for cervical teratoma. J Pediatr Surg 38:E12
Naden RP, Rosenfeld CR (1981) Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep. J Clin Invest 68:468–474
Noah MM, Norton ME, Sandberg P et al. (2002) Short-term maternal outcomes that are associated with the EXIT procedure, as compared with caesarean delivery. Am J Obstet Gynecol 186:773–777
Ogamo M, Sugiyama T, Maeda Y et al. (2005) The EXIT procedure in giant fetal neck masses. Fetal Diagn Ther 20:214–218
Palahniuk RJ, Shnider SM (1974) Maternal and fetal cardiovascular and acid-base changes during halothane and isoflurane anesthesia in the pregnant ewe. Anesthesiology 41:462–472
Peng ATC, Gorman RS, Shulman SM (1989) Intravenous nitroglycerine for uterine relaxation in the postpartum patient with retained placenta. Anesthesiology 71:172–173
Rosen MA (2001) Anesthesia for fetal procedures and surgery. Yonsei Med J 42:669–680
Rosenfeld CR, Naden RP (1989) Uterine and nonuterine vascular responses to to angiotensin II in bovine pregnancy. Am J Physiol 257:H17–24
Schwartz DA, Moriarty KP, Tashjian DB et al. (2001) Anesthetic management of the EXIT procedure. J Clin Anesth 13:387–391
Simone CA de, Norris MC, Leighton BL (1990) Intravenous nitroglycerin aids manual extraction of a retained placenta (letter). Anesthesiology 73:787
Sipes SL, Chestnut DH, Vincent RD, Weiner CP, Thompson CS, Chatterjee P (1991) Does magnesium sulfate alter the maternal cardiovascular response to vasopressor agents in gravid ewes? Anesthesiology 75:1010–1018
Stevens GH, Schoot BC, Smets MJW et al. (2002) The ex utero intrapartum treatment (EXIT) procedure in fetal neck masses: a case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 100:246–250
Tong C, Eisenach JC (1992) The vascular mechanism of ephedrine’s beneficial effect on uterine perfusion during pregnancy. Anesthesiology 76:792–798
Vincent R, Werhan C, Norman P et al. (1998) Prophylactic angiotensin II infusion during spinal anesthesia for elective cesarean delivery. Anesthesiology 88:1475–1479
Wagner W, Harrison MR (2002) Fetal operations in the head and neck area: current state. Head Neck 24:482–490
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Kill, C., Gebhardt, B., Schmidt, S. et al. Die EXIT-Prozedur als anästhesiologische Herausforderung. Anaesthesist 54, 1105–1110 (2005). https://doi.org/10.1007/s00101-005-0898-y
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DOI: https://doi.org/10.1007/s00101-005-0898-y