Skip to main content
Log in

Die EXIT-Prozedur als anästhesiologische Herausforderung

Fallbericht und Literaturübersicht

Anesthesiological management of the EXIT procedure

Case report and literature review

  • Kasuistiken
  • Published:
Der Anaesthesist Aims and scope Submit manuscript

Zusammenfassung

Bei der EXIT-Prozedur („ex-utero intra-partum treatment“) erfolgt eine invasive Versorgung des Feten im Rahmen einer Sectio caesarea noch vor Unterbindung der Nabelschnur. Die Aufrechterhaltung der plazentaren Perfusion für die Dauer des Eingriffs erfordert ein spezielles anästhesiologisches und operatives Vorgehen. Berichtet wird der Fall einer 33-jährigen Patientin, bei der aufgrund eines großen Halstumors des Feten mit 36 Schwangerschaftswochen (SSW) eine EXIT-Prozedur in Allgemeinanästhesie zur kindlichen Atemwegssicherung durchgeführt wurde. Das anästhesiologische Vorgehen und die interdisziplinäre Aufgabenstellung werden im Kontext der Literaturdaten diskutiert.

Abstract

The ex-utero intra-partum (EXIT) procedure enables the surgeon to perform invasive procedures in an infant during cesarean section before clamping the umbilical cord. Specific anesthesiological concepts are necessary for ensuring sufficient umbilical perfusion. We report the case of a 33-year-old female undergoing cesarean section in the 36th week of pregnancy because of a large fetal cervical tumor. The EXIT procedure was performed in order to secure the infant’s airway during delivery. The anesthesiological management and interdisciplinary tasks are discussed in the literature review.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Bealer JF, Skarsgard ED, Hedrick MH et al. (1995) The PLUG odyssey: adventures in experimental tracheal occlusion. J Pediatr Surg 30:361–365

    Google Scholar 

  2. Biehl DR, Yarnell R, Wade JG, Sitar D (1983) The uptake of isoflurane by the foetal lamb in utero: effect on regional blood flow. Can Anaesth Soc J 30:581–586

    Google Scholar 

  3. Bouchard S, Johnson MP, Flake AW et al. (2002) The EXIT procedure: experience and outcome in 31 cases. J Pediatr Surg 37:418–426

    Google Scholar 

  4. Cox PBW, Gogarten W, Stümper D, Marcus MAE (2004) Fetal surgery, anaesthesiological considerations. Curr Opin Anaesthesiol 17:235–240

    Google Scholar 

  5. Dahlgren G, Törnberg DC, Pregner K, Irestedt L (2004) Four cases of the EXIT procedure: anesthetic implications. Int J Obstet Anesth 13:178–182

    Google Scholar 

  6. Gaiser R, Kurth CD (1999) Anesthetic considerations for fetal surgery. Semin Perinatol 23:507–514

    Google Scholar 

  7. Gaiser R, Kurth CD, Cohen D, Crombleholme T (1999) The cesarean delivery of a twin gestation under 2 minimal alveolar anesthetic concentration isoflurane: one normal and one with a large neck mass. Anesth Analg 88:584–586

    Google Scholar 

  8. Gogarten W, Aken H van, Marcus MAE (2000) Fetal surgery: general or regional anaesthesia? Curr Opin Anaesthesiol 13:277–281

    Google Scholar 

  9. Harrison MR, Adzick NS, Flake AW et al. (1996) Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg 31:1339–1348

    Google Scholar 

  10. Hinrose S, Farmer DL, Lee H, Nobuhara KK, Harrison MR (2004) The ex utero intrapartum treatment procedure: looking back at the EXIT. J Pediatr Surg 39:375–380

    Google Scholar 

  11. Katz VL, Farmer RM (1999) Controversies in tocolytic therapy. Clin Obstet Gynecol 42:802–819

    Google Scholar 

  12. Leva E, Pansini L, Fava G, Maestri L, Pansini A, Selvaggio G (2005) The role of the surgeon in the case of a giant neck mass in the EXIT procedure. J Pediatr Surg 40:748–750

    Google Scholar 

  13. MacKenzie TC, Crombleholme TM, Flake AW (2002) The ex-utero intrapartum treatment. Curr Opin Pediatr 14:453–458

    Google Scholar 

  14. Mayer DC, Weeks SK (1992) Antepartum uterine relaxation with nitroglycerin at Cesarian delivery. Can J Anaesth 39:166–169

    Google Scholar 

  15. Mychaliska GB, Bealer JF, Rosen MA, Adzick NS, Harrison MR (1997) Operating on placental support: the ex utero intra partum procedure. J Pediatr Surg 32:227–231

    Google Scholar 

  16. Myers LB, Bulich LA, Mizrahi A et al. (2003) Ultrasonographic guidance for location of the trachea during the EXIT procedure for cervical teratoma. J Pediatr Surg 38:E12

    Google Scholar 

  17. Naden RP, Rosenfeld CR (1981) Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep. J Clin Invest 68:468–474

    Google Scholar 

  18. Noah MM, Norton ME, Sandberg P et al. (2002) Short-term maternal outcomes that are associated with the EXIT procedure, as compared with caesarean delivery. Am J Obstet Gynecol 186:773–777

    Google Scholar 

  19. Ogamo M, Sugiyama T, Maeda Y et al. (2005) The EXIT procedure in giant fetal neck masses. Fetal Diagn Ther 20:214–218

    Google Scholar 

  20. Palahniuk RJ, Shnider SM (1974) Maternal and fetal cardiovascular and acid-base changes during halothane and isoflurane anesthesia in the pregnant ewe. Anesthesiology 41:462–472

    Google Scholar 

  21. Peng ATC, Gorman RS, Shulman SM (1989) Intravenous nitroglycerine for uterine relaxation in the postpartum patient with retained placenta. Anesthesiology 71:172–173

    Google Scholar 

  22. Rosen MA (2001) Anesthesia for fetal procedures and surgery. Yonsei Med J 42:669–680

    Google Scholar 

  23. Rosenfeld CR, Naden RP (1989) Uterine and nonuterine vascular responses to to angiotensin II in bovine pregnancy. Am J Physiol 257:H17–24

    Google Scholar 

  24. Schwartz DA, Moriarty KP, Tashjian DB et al. (2001) Anesthetic management of the EXIT procedure. J Clin Anesth 13:387–391

    Google Scholar 

  25. Simone CA de, Norris MC, Leighton BL (1990) Intravenous nitroglycerin aids manual extraction of a retained placenta (letter). Anesthesiology 73:787

    Google Scholar 

  26. Sipes SL, Chestnut DH, Vincent RD, Weiner CP, Thompson CS, Chatterjee P (1991) Does magnesium sulfate alter the maternal cardiovascular response to vasopressor agents in gravid ewes? Anesthesiology 75:1010–1018

    Google Scholar 

  27. Stevens GH, Schoot BC, Smets MJW et al. (2002) The ex utero intrapartum treatment (EXIT) procedure in fetal neck masses: a case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 100:246–250

    Google Scholar 

  28. Tong C, Eisenach JC (1992) The vascular mechanism of ephedrine’s beneficial effect on uterine perfusion during pregnancy. Anesthesiology 76:792–798

    Google Scholar 

  29. Vincent R, Werhan C, Norman P et al. (1998) Prophylactic angiotensin II infusion during spinal anesthesia for elective cesarean delivery. Anesthesiology 88:1475–1479

    Google Scholar 

  30. Wagner W, Harrison MR (2002) Fetal operations in the head and neck area: current state. Head Neck 24:482–490

    Google Scholar 

Download references

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C. Kill.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kill, C., Gebhardt, B., Schmidt, S. et al. Die EXIT-Prozedur als anästhesiologische Herausforderung. Anaesthesist 54, 1105–1110 (2005). https://doi.org/10.1007/s00101-005-0898-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00101-005-0898-y

Schlüsselwörter

Keywords

Navigation