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Salmonella infections in a cancer center

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Abstract

Data concerning 40 patients hospitalized in a cancer center andSalmonella infection were analyzed. Hematological malignancy was present in 24 patients (60%) and solid tumor in 14 patients (35%). Among the predisposing factors, antineoplastic chemotherapy was the most frequent (60%) followed by antacid use (47.5%), corticosteroids (37.5%), granulocytopenia below 500 neutrophils/μl (15%), surgery (10%) and splenectomy (2.5%). Bacteremia was the most frequent clinical syndrome accounting for 42.5% of the patients. Focal infection, enteritis and carrier state accounted for the remaining 30%, 20% and 7.5% respectively.Salmonella typhimurium andS. dublin represented 65% of the isolates, with clear association between serotypedublin and bacteremia. AllS. dublin isolates were resistant to chloramphenicol. Amongdublin andtyphimurium serotypes, 20% the isolates were resistant to the traditional antibiotics used in salmonellosis (ampicillin, chloramphenicol, cotrimoxazole). All strains were susceptible in vitro to cephalosporins. The frequency of relapse was 15% and the overall mortality (within 30 days) attributed toSalmonella infection was 15%.

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Author information

Author notes

  1. P. van der Auwera

    Present address: F. Hoffmann-La Roche SA, Clinical Research, CH-4002, Basel, Switzerland

  2. F. Meunier

    Present address: EORTC Central Office, Avenue E. Mounier, 83, B-1200, Brussels, Belgium

Authors and Affiliations

  1. Servicio Medecina Interna, Hospital Dipreca, Avenida Vital Apoquindo 1200, Los Condes, Santiago, Chile

    L. M. Noriega

  2. Service de Médecine Interne Institut Jales Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Rue Héger Bordet 1, B-1000, Bruxelles, Belgium

    P. van der Auwera, D. Daneau, F. Meunier & M. Aoun

  3. Laboratoire d'Investigation, Clinique Henri Tagnon, Clinique des Maladies Infecticuses Institut Jales Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Rue Héger Bordet 1, B-1000, Bruxelles, Belgium

    P. van der Auwera, D. Daneau, F. Meunier & M. Aoun

  4. Laboratoire de Microbiologie, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Rue Héger Bordet 1, B-1000, Bruxelles, Belgium

    P. van der Auwera, D. Daneau, F. Meunier & M. Aoun

Authors
  1. L. M. Noriega
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  4. F. Meunier
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  5. M. Aoun
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Noriega, L.M., van der Auwera, P., Daneau, D. et al. Salmonella infections in a cancer center. Support Care Cancer 2, 116–122 (1994). https://doi.org/10.1007/BF00572093

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