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PET and PET-CT of Lung Cancer

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Positron Emission Tomography

Part of the book series: Methods in Molecular Biology ((MIMB,volume 727))

Abstract

Accurate staging is essential to offer the patient the most effective available treatment and the best estimate of prognosis. In non-small cell lung cancer (NSCLC), surgical resection offers the best chance of cure in the early stages, either alone or in combination with chemo- or radiotherapy at the more advanced stages. However, many patients present with metastatic disease at the time of diagnosis. Both computed tomography (CT) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) play an important role in the diagnosis and staging of lung cancer. CT provides excellent morphologic information but has significant limitations in differentiating between benign and malignant lesions either in an organ or in lymph nodes. FDG-PET is highly accurate in the detection of mediastinal lymph node metastases as well as extratharacic metastases. However, due to the poor anatomic information provided by PET, additional morphologic information is needed to properly locate a lesion. Imaging with PET integrated with computed tomography (PET/CT) offers essential advantages in comparison to PET alone, CT alone, or visual correlation of separate PET and CT. A combined PET/CT system provides PET and CT images perfectly coregistered so that lesions can be exactly localized.

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Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, University Hospital of Zürich, Zürich, Switzerland

    Hans C. Steinert

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  1. Hans C. Steinert
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Correspondence to Hans C. Steinert .

Editor information

Editors and Affiliations

  1. Dept. Radiology, University of Iowa, Hawkins Drive 200, Iowa City, 52242-1009, Iowa, USA

    Malik E. Juweid

  2. , Dept. Nuclear Medicine & PET Research, VU University Medical Centre, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands

    Otto S. Hoekstra

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© 2011 Humana Press

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Steinert, H.C. (2011). PET and PET-CT of Lung Cancer. In: Juweid, M., Hoekstra, O. (eds) Positron Emission Tomography. Methods in Molecular Biology, vol 727. Humana Press. https://doi.org/10.1007/978-1-61779-062-1_3

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  • DOI: https://doi.org/10.1007/978-1-61779-062-1_3

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-061-4

  • Online ISBN: 978-1-61779-062-1

  • eBook Packages: Springer Protocols

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