Summary
The prediction of B-cell epitopes is desirable for designing peptide-based vaccines, or generating antibodies especially if the purified protein is difficult to obtain and immunization has to be performed with protein-derived synthetic peptides. A number of freely available tools predict epitopes from protein sequence or structural information. The handling of these tools is described and the predictive power is assessed using test data based on the proteome of HIV, where comprehensive epitope mapping data are available.
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The author thanks Dr. Tatiana Reimer and Prof. Maik Kschischo for their advice.
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© 2009 Humana Press, a part of Springer Science+Business Media, LLC
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Reimer, U. (2009). Prediction of Linear B-cell Epitopes. In: Schutkowski, M., Reineke, U. (eds) Epitope Mapping Protocols. Methods in Molecular Biology™, vol 524. Humana Press. https://doi.org/10.1007/978-1-59745-450-6_24
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DOI: https://doi.org/10.1007/978-1-59745-450-6_24
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