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Malignant lymphoma arising in the submandibular gland in a patient with HIV infection and associated lymphadenopathy

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Abstract

Human immunodeficiency virus (HIV) infection is associated with an increased risk of malignant disease. However, a case of diffuse large B-cell lymphoma arising in the submandibular gland in a patient with HIV infection has never been reported. This report describes a case of a patient with HIV infection and HIV-associated lymphadenopathy who developed diffuse large B-cell lymphoma (DLBCL) arising in the submandibular gland. Both the submandibular gland and its regional lymph nodes were positive by positron emission tomography/computed tomography (PET/CT), which led to radical neck dissection. The pathological diagnosis was DLBCL in the submandibular gland, however, that of regional lymph nodes was HIV-associated lymphadenopathy and was not malignancy. PET/CT-based staging can make a false-positive result in lymph nodes of patients with HIV infection due to HIV-associated lymphadenopathy.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan

    Yoshifumi Matsumoto, Yasunao Kogashiwa & Naoyuki Kohno

  2. Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan

    Makoto Mochizuki

Authors
  1. Yoshifumi Matsumoto
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  2. Yasunao Kogashiwa
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  3. Makoto Mochizuki
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  4. Naoyuki Kohno
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Corresponding author

Correspondence to Naoyuki Kohno.

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Matsumoto, Y., Kogashiwa, Y., Mochizuki, M. et al. Malignant lymphoma arising in the submandibular gland in a patient with HIV infection and associated lymphadenopathy. Int Canc Conf J 4, 117–121 (2015). https://doi.org/10.1007/s13691-014-0182-6

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  • DOI: https://doi.org/10.1007/s13691-014-0182-6

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