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Physical Activity in the Prevention of Weight Gain: the Impact of Measurement and Interpretation of Associations

  • Etiology of Obesity (T Gill, Section Editor)
  • Published:
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Abstract

Purpose of Review

To what extent do different methods of physical activity measurement and statistical analysis influence the reported associations between physical activity and weight gain?

Recent Findings

The obesity epidemic has led to a focus on lifestyle approaches to the prevention of weight gain. Physical activity is one such approach. A number of studies have reported beneficial associations between higher levels of physical activity and weight gain at the population level. However, limitations of physical activity measurement and analytical models in some of these studies are likely to have resulted in overestimation of the strength of association.

Summary

Understanding the limitations of assessment methods and analytical models used in epidemiological research should facilitate more realistic appraisal for physical activity to prevent weight gain at the population level and inform approaches to future research.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Sallis RE. Exercise is medicine and physicians need to prescribe it! Br J Sports Med. 2009;43(1):3–4.

    Article  CAS  PubMed  Google Scholar 

  2. Academy of Medical Royal Colleges. Exercise: the miracle cure and the role of the doctor in promoting it. London: Academy of Medical Royal Colleges; 2015. p. 58.

    Google Scholar 

  3. Galgani J, Ravussin E. Energy metabolism, fuel selection and body weight regulation. Int J Obes. 2009;32(S7):S109.

    Article  CAS  Google Scholar 

  4. Jéquier E, Tappy L. Regulation of body weight in humans. Physiol Rev. 1999 Apr 1;79(2):451–80.

    Article  PubMed  Google Scholar 

  5. Donnelly JE, Honas JJ, Smith BK, Mayo MS, Gibson CA, Sullivan DK, et al. Aerobic exercise alone results in clinically significant weight loss for men and women: Midwest exercise trial 2. Obesity. 2013;21(3):E219–28.

    Article  PubMed  Google Scholar 

  6. Malhotra R, Østbye T, Riley CM, Finkelstein EA. Young adult weight trajectories through midlife by body mass category. Obesity. 2013;21(9):1923–34.

    PubMed  Google Scholar 

  7. Luís Griera J, María Manzanares J, Barbany M, Contreras J, Amigó P, Salas-Salvadó J. Physical activity, energy balance and obesity. Public Health Nutr. 2007;10(10A):1194–9.

    Article  PubMed  Google Scholar 

  8. Hall KD, Heymsfield SB, Kemnitz JW, Klein S, Schoeller DA, Speakman JR. Energy balance and its components: implications for body weight regulation. Am J Clin Nutr. 2012;95(4):989–94.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Adams SA, Matthews CE, Ebbeling CB, Moore CG, Cunningham JE, Fulton J, et al. The effect of social desirability and social approval on self-reports of physical activity. Am J Epidemiol. 2005;161(4):389–98.

    Article  PubMed  Google Scholar 

  10. Shim J-S, Oh K, Kim HC. Dietary assessment methods in epidemiologic studies. Epidemiol Health. 2014;36:e2014009.

    Article  PubMed  PubMed Central  Google Scholar 

  11. •• Shephard RJ. Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med. 2003;37(3):197–206 discussion 206. A comprehensive review that discusses several limitations to assessing physical activity by questionnaires in large-scale observational studies.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Church TS. The role of exercise and physical activity in weight loss and maintenance. Prog Cardiovasc Dis. 2014 Jan 1;56(4):441–7.

    Article  PubMed  Google Scholar 

  13. • 2018 Physical Activity Guidelines Advisory Committee. 2018 Physical Activity Guidelines Advisory Committee scientific report. Washington, DC: U.S. Department of Health and Human Services; 2018. Details the review process and evidence that inform the current US physical activity guidelines.

  14. Bea JW, Cussler EC, Going SB, Blew RM, Metcalfe LL, Lohman TG. Resistance training predicts 6-yr body composition change in postmenopausal women. Med Sci Sports Exerc. 2010;42(7):1286–95.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Brien SE, Katzmarzyk PT, Craig CL, Gauvin L. Physical activity, cardiorespiratory fitness and body mass index as predictors of substantial weight gain and obesity: the Canadian Physical Activity Longitudinal Study. Can J Public Health. 2007;98(2):121–4.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Drenowatz C, Gribben N, Wirth MD, Hand GA, Shook RP, Burgess S, et al. The association of physical activity during weekdays and weekend with body composition in young adults. J Obes. 2016;2016:8236439.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Drenowatz C, Hill JO, Peters JC, Soriano-Maldonado A, Blair SN. The association of change in physical activity and body weight in the regulation of total energy expenditure. Eur J Clin Nutr. 2017 Mar;71(3):377–82.

    Article  CAS  PubMed  Google Scholar 

  18. French SA, Mitchell NR, Hannan PJ. Decrease in television viewing predicts lower body mass index at 1-year follow-up in adolescents, but not adults. J Nutr Educ Behav. 2012;44(5):415–22.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Gebel K, Ding D, Bauman AE. Volume and intensity of physical activity in a large population-based cohort of middle-aged and older Australians: prospective relationships with weight gain, and physical function. Prev Med. 2014;60:131–3.

    Article  PubMed  Google Scholar 

  20. Gradidge PJ-L, Norris SA, Micklesfield LK, Crowther NJ. The role of lifestyle and psycho-social factors in predicting changes in body composition in black South African women. PLoS One. 2015;10(7):e0132914.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Hankinson AL, Daviglus ML, Bouchard C, Carnethon M, Lewis CE, Schreiner PJ, et al. Maintaining a high physical activity level over 20 years and weight gain. JAMA. 2010;304(23):2603–10.

    Article  CAS  PubMed  Google Scholar 

  22. Lee I-M, Djoussé L, Sesso HD, Wang L, Buring JE. Physical activity and weight gain prevention. JAMA. 2010;303(12):1173–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. MacInnis RJ, Hodge AM, Dixon HG, Peeters A, Johnson LE, English DR, et al. Predictors of increased body weight and waist circumference for middle-aged adults. Public Health Nutr. 2014;17(5):1087–97.

    Article  PubMed  Google Scholar 

  24. Mortensen LH, Siegler IC, Barefoot JC, Grønbæk M, Sørensen TIA. Prospective associations between sedentary lifestyle and BMI in midlife. Obesity. 2006;14(8):1462–71.

    Article  PubMed  Google Scholar 

  25. Shibata A, Oka K, Sugiyama T, Salmon J, Dunstan DW, Owen N. Physical activity, television viewing time, and 12-year changes in waist circumference. Med Sci Sports Exerc. 2016;48(4):633–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Sims ST, Larson JC, Lamonte MJ, Michael YL, Martin LW, Johnson KC, et al. Physical activity and body mass: changes in younger versus older postmenopausal women. Med Sci Sports Exerc. 2012;44(1):89–97.

    Article  PubMed  Google Scholar 

  27. Smith KJ, Gall SL, McNaughton SA, Cleland VJ, Otahal P, Dwyer T, et al. Lifestyle behaviours associated with 5-year weight gain in a prospective cohort of Australian adults aged 26-36 years at baseline. BMC Public Health. 2017;17(1):54.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Adair LS, Gultiano S, Suchindran C. 20-year trends in Filipino women’s weight reflect substantial secular and age effects. J Nutr. 2011;141(4):667–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Basterra-Gortari FJ, Bes-Rastrollo Pardo-Fernández M, Forga L, Martinez JA, Martínez-González MA. Changes in weight and physical activity over two years in Spanish alumni. Med Sci Sports Exerc. 2009;41(3):516–22.

  30. Blanck HM, McCullough ML, Patel AV, Gillespie C, Calle EE, Cokkinides VE, et al. Sedentary behavior, recreational physical activity, and 7-year weight gain among postmenopausal U.S. women. Obesity. 2007;15(6):1578–88.

    Article  PubMed  Google Scholar 

  31. Botoseneanu A, Liang J. The effect of stability and change in health behaviors on trajectories of body mass index in older Americans: a 14-year longitudinal study. J Gerontol Ser A. 2012;67(10):1075–84.

    Article  Google Scholar 

  32. Brown WJ, Kabir E, Clark BK, Gomersall SR. Maintaining a healthy BMI. Am J Prev Med. 2016;51(6):e165–78.

    Article  PubMed  Google Scholar 

  33. Chiriboga DE, Ma Y, Li W, Olendzki BC, Pagoto SL, Merriam PA, et al. Gender differences in predictors of body weight and body weight change in healthy adults. Obesity. 2008;16(1):137–45.

    Article  PubMed  Google Scholar 

  34. Colchero MA, Caballero B, Bishai D. The effect of income and occupation on body mass index among women in the Cebu Longitudinal Health and Nutrition Surveys (1983–2002). Soc Sci Med. 2008;66(9):1967–78.

    Article  PubMed  Google Scholar 

  35. de Munter JS, Tynelius P, Magnusson C, Rasmussen F. Longitudinal analysis of lifestyle habits in relation to body mass index, onset of overweight and obesity: results from a large population-based cohort in Sweden. Scand J Public Health. 2015;43(3):236–45.

    Article  PubMed  Google Scholar 

  36. Hamer M, Brunner EJ, Bell J, Batty GD, Shipley M, Akbaraly T, et al. Physical activity patterns over 10 years in relation to body mass index and waist circumference: the Whitehall II Cohort Study. Obesity. 2013;21(12):E755–61.

    Article  CAS  PubMed  Google Scholar 

  37. Hillemeier MM, Weisman CS, Chuang C, Downs DS, McCall-Hosenfeld J, Camacho F. Transition to overweight or obesity among women of reproductive age. J Women's Health. 2011;20(5):703–10.

    Article  Google Scholar 

  38. Kaikkonen JE, Mikkilä V, Juonala M, Keltikangas-Järvinen L, Hintsanen M, Pulkki-Råback L, et al. Factors associated with six-year weight change in young and middle-aged adults in the Young Finns Study. Scand J Clin Lab Invest. 2015;75(2):133–44.

    Article  PubMed  Google Scholar 

  39. Kelly MC, Latner JD. Evaluating patterns of weight and body composition change among college women. Eat Behav. 2015;17:157–62.

    Article  PubMed  Google Scholar 

  40. Moholdt T, Wisløff U, Lydersen S, Nauman J. Current physical activity guidelines for health are insufficient to mitigate long-term weight gain: more data in the fitness versus fatness debate (the HUNT study, Norway). Br J Sports Med. 2014;48(20):1489–96.

    Article  PubMed  Google Scholar 

  41. Parsons TJ, Manor O, Power C. Physical activity and change in body mass index from adolescence to mid-adulthood in the 1958 British cohort. Int J Epidemiol. 2006;35(1):197–204.

    Article  PubMed  Google Scholar 

  42. Rosenberg L, Kipping-Ruane KL, Boggs DA, Palmer JR. Physical activity and the incidence of obesity in young African-American women. Am J Prev Med. 2013;45(3):262–8.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Sjösten N, Kivimäki M, Singh-Manoux A, Ferrie JE, Goldberg M, Zins M, et al. Change in physical activity and weight in relation to retirement: the French GAZEL Cohort Study. BMJ Open. 2012;2(1):e000522.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Williams PT, Wood PD. The effects of changing exercise levels on weight and age-related weight gain. Int J Obes. 2006;30(3):543–51.

    Article  CAS  Google Scholar 

  45. Williams PT. Maintaining vigorous activity attenuates 7-yr weight gain in 8340 runners. Med Sci Sports Exerc. 2007;39(5):801–9.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Williams PT, Thompson PD. Dose-dependent effects of training and detraining on weight in 6406 runners during 7.4 years. Obesity. 2006;14(11):1975–84.

    Article  PubMed  Google Scholar 

  47. Britton KA, Lee I-M, Wang L, Gaziano JM, Manson JE, Buring JE, et al. Physical activity and the risk of becoming overweight or obese in middle-aged and older women. Obesity. 2012;20(5):1096–103.

    Article  CAS  PubMed  Google Scholar 

  48. Ragland DR. Dichotomizing continuous outcome variables: dependence of the magnitude of association and statistical power on the cutpoint. Epidemiology. 1992 Sep;3(5):434–40.

    Article  CAS  PubMed  Google Scholar 

  49. Kahlert D. Maintenance of physical activity: do we know what we are talking about? Prev Med Rep. 2015;2:178–80.

    Article  PubMed  PubMed Central  Google Scholar 

  50. •• Royston P, Altman DG, Sauerbrei W. Dichotomizing continuous predictors in multiple regression: a bad idea. Stat Med. 2006;25(1):127–41. An important paper that clearly describes and explains a variety of issues that may occur when categorising continuous predictor variables in regression analyses.

    Article  PubMed  Google Scholar 

  51. Lovasi GS, Underhill LJ, Jack D, Richards C, Weiss C, Rundle A. At odds: concerns raised by using odds ratios for continuous or common dichotomous outcomes in research on physical activity and obesity. Open Epidemiol J. 2012;5(1):13–7.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Hill AB. The environment and disease: association or causation? Proc R Soc Med. 1965;58(5):295.

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Bennette C, Vickers A. Against quantiles: categorization of continuous variables in epidemiologic research, and its discontents. BMC Med Res Methodol. 2012;12(1).

  54. Harrell FE Jr. Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis. 2nd ed. Cham: Springer-Verlag; 2015. 582 p. (Springer Series in Statistics).

  55. Greenland S. Avoiding power loss associated with categorization and ordinal scores in dose-response and trend analysis. Epidemiology. 1995;6(4):450–4.

    Article  CAS  PubMed  Google Scholar 

  56. May S, Bigelow C. Modeling nonlinear dose-response relationships in epidemiologic studies: statistical approaches and practical challenges. Dose-Response. 2018;3(4):474–90.

    Google Scholar 

  57. Wainer H, Gessaroli M, Verdi M. Visual revelations. CHANCE. 2013;19(1):49–52.

    Article  Google Scholar 

  58. Royston P. A strategy for modelling the effect of a continuous covariate in medicine and epidemiology. Stat Med. 2000;19(14):1831–47.

    Article  CAS  PubMed  Google Scholar 

  59. Kassirer JP, Angell M. Redundant publication: a reminder. N Engl J Med. 1995;333(7):449–50.

    Article  CAS  PubMed  Google Scholar 

  60. Ekelund U, Kolle E, Steene-Johannessen J, Dalene KE, Nilsen AKO, Anderssen SA, et al. Objectively measured sedentary time and physical activity and associations with body weight gain: does body weight determine a decline in moderate and vigorous intensity physical activity? Int J Obes. 2017;41(12):1769–74.

    Article  CAS  Google Scholar 

  61. Staiano AE, Martin CK, Champagne CM, Rood JC, Katzmarzyk PT. Sedentary time, physical activity, and adiposity in a longitudinal cohort of nonobese young adults. Am J Clin Nutr. 2018;108(5):946–52.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Dugas LR, Kliethermes S, Plange-Rhule J, Tong L, Bovet P, Forrester TE, et al. Accelerometer-measured physical activity is not associated with two-year weight change in African-origin adults from five diverse populations. PeerJ. 2017;5:e2902.

    Article  PubMed  PubMed Central  Google Scholar 

  63. • Richmond RC, Davey Smith G, Ness AR, den Hoed M, McMahon G, Timpson NJ. Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. Ludwig DS, editor. PLoS Med 2014;11(3):e1001618. This study demonstrates that increasing BMI and adiposity leads to a causal reduction in both total and moderate- to vigorous-intensity physical activity.

  64. Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1):1–22.

    Article  Google Scholar 

  65. Ekelund U, Brage S, Besson H, Sharp S, Wareham NJ. Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality? Am J Clin Nutr. 2008;88(3):612–7.

    Article  CAS  PubMed  Google Scholar 

  66. Golubic R, Ekelund U, Wijndaele K, Luben R, Khaw K-T, Wareham NJ, et al. Rate of weight gain predicts change in physical activity levels: a longitudinal analysis of the EPIC-Norfolk cohort. Int J Obes. 2013;37(3):404–9.

    Article  CAS  Google Scholar 

  67. Golubic R, Wijndaele K, Sharp SJ, Simmons RK, Griffin SJ, Wareham NJ, et al. Physical activity, sedentary time and gain in overall and central body fat: 7-year follow-up of the ProActive trial cohort. Int J Obes. 2015;39(1):142–8.

    Article  CAS  Google Scholar 

  68. Nocon M, Hiemann T, Müller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2008;15(3):239–46.

    Article  PubMed  Google Scholar 

  69. Samitz G, Egger M, Zwahlen M. Domains of physical activity and all-cause mortality: systematic review and dose–response meta-analysis of cohort studies. Int J Epidemiol. 2011;40(5):1382–400.

    Article  PubMed  Google Scholar 

  70. Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, et al. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet. 2016;388(10051):1302–10.

    Article  PubMed  Google Scholar 

  71. Ekelund U, Brown WJ, Steene-Johannessen J, Fagerland MW, Owen N, Powell KE, Bauman AE, Lee IM Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants. Br J Sports Med 2018;bjsports-2017-098963.

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  1. Department of Sports Medicine, Norwegian School of Sport Sciences, Ullevål Stadion, PO Box 4014, 0806, Oslo, Norway

    Paul Remy Jones & Ulf Ekelund

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Jones, P.R., Ekelund, U. Physical Activity in the Prevention of Weight Gain: the Impact of Measurement and Interpretation of Associations. Curr Obes Rep 8, 66–76 (2019). https://doi.org/10.1007/s13679-019-00337-1

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