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Prognostic value of cyclin E expression in breast cancer: a meta-analysis

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Tumor Biology

Abstract

Cyclin E is an important regulator of cell cycle progression. Various studies examined the relationship between cyclin E overexpression with the clinical outcome in patients with breast cancer but yielded conflicting results. Electronic databases updated to May 2013 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between cyclin E overexpression and survival of patients with breast cancer. Survival data were aggregated and quantitatively analyzed. We conducted a final analysis of 7,759 patients from 23 eligible studies and evaluated the correlation between cyclin E overexpression and survival in patients with breast cancer. Combined hazard ratios suggested that cyclin E overexpression had an unfavorable impact on overall survival (OS) (hazard ratio (HR) = 1.30, 95 % confidence interval (CI), 1.12–1.49) and breast cancer-specific survival (BCSS) (HR = 1.48, 95 % CI, 1.03–1.93), but not disease-free survival (HR = 1.11; 95 % CI, 0.96–1.27) in patients with breast cancer. Significantly, risks were found among stage I–II breast cancer for (HR = 1.75; 95 % CI, 1.30–2.19). Cyclin E overexpression is associated with poor OS and BCSS in breast cancer.

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Acknowledgments

This work was supported in part by the National Natural Science Foundation of China (81172501).

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  1. State Key Laboratory of Reproductive Medicine, Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, China

    Sheng Gao, Jing-Jing Ma & Cheng Lu

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  1. Sheng Gao
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  2. Jing-Jing Ma
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  3. Cheng Lu
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Correspondence to Cheng Lu.

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Sheng Gao and Jing-Jing Ma contributed equally to this work and should be considered as co-first authors.

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Gao, S., Ma, JJ. & Lu, C. Prognostic value of cyclin E expression in breast cancer: a meta-analysis. Tumor Biol. 34, 3423–3430 (2013). https://doi.org/10.1007/s13277-013-0915-8

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