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Acid Phosphatase as a Marker in Malaria

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Abstract

The serum acid phosphatase (ACP) activity and Hemoglobin (Hb) levels were measured in malaria patients and nonmalarial fever patients. The results were compared with normal healthy control subjects. ACP was significantly increased (P < 0.001) in all the malaria patients. ACP was significantly higher in Plasmodium falcifarum malaria and mixed malaria when compared to Plasmodium vivax malaria. Hb levels were significantly decreased in all the malaria patients which indicates that malaria parasite uses host erythrocyte Hb as a major nutrient source. There is negative correlation(r = −0.478) between ACP and Hb in malaria patients, which is highly significant. These results suggest that the measurement of ACP could be used as a marker for malaria.

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References

  1. George YS, Lois MJ, Hary LR. Th estimation of serum inorganic phosphate in acid and alkaline phosphatase activity. J Biol Chem. 1942;142:921–33.

    Google Scholar 

  2. Dissing J. Immunochemical characterization of human red cell acid phosphatase isoenzymes. Biochem Genet. 1987;25:11–2.

    Google Scholar 

  3. Vasudevan DM, Sreekumari S. Text book of biochemistry. 3rd ed ed. New Delhi: Jaypee Brothers Medical Publishers (P) Limited; 2001. p. 50–2.

    Google Scholar 

  4. Palmarino R, Agostino R, Zgloria F, Lucarelli P, Businco L, Antognoni G, Maggioni G, Workman PL, Bottini E. Red cell acid phosphatase: another polymorphism correlated with malaria. Am J Phys Anthrpol. 2005;43(2):177–85.

    Article  Google Scholar 

  5. White NJ. The pathophysiology of malaria. Adv Parasitol. 1992;31:34–173.

    Article  Google Scholar 

  6. Bruce-Chwatt LJ. History of malaria from prehistory to eradication. Malaria, principles and practices of malariology. Edinburgh: Churchill Livingstone; 1988. p. 1–59.

    Google Scholar 

  7. Bergmeyer HV. Methods of enzymatic analysis. Weinheiam: Verlag Chemie; 1984. p. 92.

    Google Scholar 

  8. Varley H. Practical Clinical Biochemistry. 5th ed. In: Determination of serum acid phosphatase. London: William Heinemann Medical Books Ltd; 1980. p 913–915.

  9. Anderson HR, Nielsen JB, Nielsen F, Philippe G. Antioxidative enzyme activities in human erythrocytes. Clin Chem. 1997;43(4):562–8.

    Google Scholar 

  10. Gupta CM. Red cell membrane alterations in malaria. Ind J Biochem Biophys. 1988;25:20–4.

    CAS  Google Scholar 

  11. Prassannachandra, D’Souza V, D’Souza B. Comparative study on lipid peroxidation and antioxidants vitamins E & C in falciparum and vivax malaria. Ind J Clin Biochem. 2006;21(2):103–6.

    Article  Google Scholar 

  12. Goldberg DE, Slater AF, Cerani A, Henderson GB. Hemoglobin degradation in malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proc Natl Acad Sci. 1990;87(8):2931–5.

    Article  PubMed  CAS  Google Scholar 

  13. Kremsner PG, Greve B, Lell B, Luckner D, Schmid D. Malarial anemia in African children associated with high oxygen radical production. Lancet. 2000;355:40–1.

    Article  PubMed  CAS  Google Scholar 

  14. Bhabhani SD, Nilini KN. Evidence for erythrocyte lipid peroxidation in acute falciparum malaria. Trans R Soc Trop Med Hyg. 1999;93:58–62.

    Article  Google Scholar 

  15. Clark IA, Hunt NH. Evidence for reactive oxygen intermediates causing the hemolysis and parasite death in malaria. Infect Immun. 1983;39:1–6.

    PubMed  CAS  Google Scholar 

  16. D’Souza B, D’Souza V, Swagatha H, Vijayalaxmi K, Namratha AS. Erythrocyte superoxide dismutase and catalase and their correlation with malondialdehyde in falciparum and vivax malaria. Biomed Res. 2009;20(1):25–7.

    Google Scholar 

  17. Garba IH, Gatsing D, Uborn G. Elevated total and isoenzyme forms of acid phosphatase in falciparum malaria. Comput Rendus Biol. 2006;329(2):75–8.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Manipal University, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore, 575004, India

    Benedicta D’Souza,  Sreekantha & Vivian D’Souza

  2. Department of Medicine, Manipal University, Kasturba Medical College, Manipal, India

    Rajeevalochana Parthasarathy

Authors
  1. Benedicta D’Souza
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  2. Rajeevalochana Parthasarathy
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  3. Sreekantha
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  4. Vivian D’Souza
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Correspondence to Benedicta D’Souza.

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D’Souza, B., Parthasarathy, R., Sreekantha et al. Acid Phosphatase as a Marker in Malaria. Ind J Clin Biochem 26, 396–399 (2011). https://doi.org/10.1007/s12291-011-0137-z

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  • DOI: https://doi.org/10.1007/s12291-011-0137-z

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