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Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats

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Abstract

The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100–400μg) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases.

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Authors and Affiliations

  1. Department of Biochemistry, C S M Medical University, Lucknow, India

    Vishnu Kumar, Ranjana Singh, Sushma Singh, Ramesh Chander, V. K. Singh & R. K. Singh

  2. Era’s Lucknow Medical College, Lucknow, India

    Farzana Mahdi

  3. BRD Medical College, Gorakhpur, India

    Shweta Saxena

  4. Division of Biochemistry, Central Drug Research Institute, Lucknow, India

    A. K. Khanna, M. M. Khan & J. K. Saxena

  5. Department of Biochemistry, Chhatrapati Shahuji Maharaj Medical University (Formerly King George’s Medical University), Lucknow, 226003, India

    R. K. Singh

Authors
  1. Vishnu Kumar
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  2. A. K. Khanna
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  3. M. M. Khan
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  4. Ranjana Singh
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  5. Sushma Singh
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  6. Ramesh Chander
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  7. Farzana Mahdi
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  8. J. K. Saxena
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  9. Shweta Saxena
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  10. V. K. Singh
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  11. R. K. Singh
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Correspondence to R. K. Singh.

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Kumar, V., Khanna, A.K., Khan, M.M. et al. Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats. Indian J Clin Biochem 24, 65–69 (2009). https://doi.org/10.1007/s12291-009-0011-4

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  • DOI: https://doi.org/10.1007/s12291-009-0011-4

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