Skip to main content
SpringerLink
Log in

Coupling of liquid chromatograph with ion-mobility spectrometer

  • Original Research
  • Published:
International Journal for Ion Mobility Spectrometry

Abstract

The paper presents the results of studying the system of a liquid chromatograph (LC) coupling with an ion-mobility spectrometer (IMS) with orthogonal electrostatic deflection of ions obtained by the electrospray method at high flow rates of the liquid under analysis (200 to 300 microL/min), which ensures stable operation of the LC/IMS analytical setup without separating the liquid flow leaving the liquid chromatograph column.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Aleksandrov ML, Gall’ LN, Krasnov NV, Nikolaev VI, Pavlenko VA, Shkurov VA (1984) Ion extraction from solution at the atmospheric pressure as a new mass-spectroscopy technique. J Anal Chem (in Russian) 9:1596–1602

    Google Scholar 

  2. Clinton A, Christopher K, Osgood M, Wu J, Wu C (2009) High resolution electrospray ionization ion mobility spectrometry. Int J Ion Mobil Spectrom 12:33–37

    Article  Google Scholar 

  3. Dahl DA (2000) SIMION 7 User’s Manual. Idaho National Engineering Lab

  4. Eiceman GA, Karpas Z (2005) Ion mobility spectrometry, 2nd edn. Taylor and Francis, Boca Raton

    Book  Google Scholar 

  5. Gieniec J, Cox HL Jr, Dole M (1972) Enhanced Electrospray Ionization for mass spectrometry and ion mobility spectrometry. Conference on MS and Allied Topics, Dallas, 216

    Google Scholar 

  6. Hill HH Jr, Siems WF, Eatherton RL, St. Louis RH, Morrissey MA, Shumate CB, McMinn DG (1992) Gas, supercritical fluid, and liquid chromatographic detection of trace organics by ion mobility spectrometry. Instr. for Trace Organic Monitoring, Lewis: Chelsea, Mich, 49–64

  7. Kebarle P, Ho Y (1997) In: Cole RB (ed) Electrospray ionization mass spectrometry: fundamentals, instrumentation and applications. Wiley, New York

    Google Scholar 

  8. Krasnov NV, YaI P, Samokish AV, Samokish VA, Khasin YI (2007) The resolving power of the ion mobility spectrometer with double consecutive ion separation at corona discharge ionization. Nauchnoe Priborostroenie (Research Instrumentation in Russian) 1:40–48

    Google Scholar 

  9. Kurnin IV, Samokish VA, Krasnov NV (2010) Simulation of operation of the ion-mobility spectrometer with the Bradbury-Nielsen ion gate. Nauchnoe Priborostroenie (Research Instrumentation in Russian ) 3:14–21

    Google Scholar 

  10. McDaniel EW, Mason EA (1976) The mobility and diffusion of ions in gases. Willey, New York, 1973

    Google Scholar 

  11. Reese CS, Taraszewsky SJ, Limero TF (1999) Near-real-time analysis of toxicologically important compounds using the volatile organic analyzer for the international space station, in: Proceedings of the 8th International Conference on IMS, Buxton, UK

  12. Shumate CB, Hill HH Jr (1989) Coronaspray nebulization and ionization of liquid samples for ion mobility spectrometry. Anal Chem 61:601–606

    Article  CAS  Google Scholar 

  13. Smith RD, Loo JA, Loo RRO, Bussmann M, Udseth HR (1991) Hydrogen/Deuterium exchange electrospray ionization mass spectrometry: a method for probing protein conformational changes in solution. Mass Spectrom Rev 10:359–451

    Article  CAS  Google Scholar 

  14. Smith RD, Loo JA, Loo RRO, Udseth HR (1992) Combined ion mobility/time-of-flight mass spectrometry study of electrospray-generated ions. Mass Spectrom Rev 11:434–443

    Google Scholar 

  15. Tadjimukhamedov FK, Stone JA, Papanastasiou D, Rodriguez JE, Mueller W, Sukumar H, Eiceman GA (2008) Liquid chromatography/electrospray ionization/ion mobility spectrometry of chlorophenols with full flow from large bore LC columns. Int J Ion Mobil Spectrom 11:51–60

    Article  CAS  Google Scholar 

  16. Wittmer D, Chen YH, Luckenbill WK, Hill HH Jr (1994) Electrospray ionization Ion mobility spectrometry. Anal Chem 66:2348–2355

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The work was performed under the State Contract in the scope of Federal Program “National System of Chemical and Biological Safety of the Russian Federation (2009–2014)”.

Author information

Authors and Affiliations

  1. Institute for Analytical Instrumentation of Russian Academy of Sciences, 26 Rizhsky pr., 190103, Saint Petersburg, Russia

    Igor V. Kurnin, Alexey A. Kayumov, Marat Z. Muradymov, Nikolay V. Krasnov & Andrey V. Samokish

Authors
  1. Igor V. Kurnin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexey A. Kayumov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marat Z. Muradymov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nikolay V. Krasnov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Andrey V. Samokish
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Igor V. Kurnin.

Additional information

The paper presents the results of studying the system of a liquid chromatograph (LC) coupling with an ion-mobility spectrometer (IMS) with orthogonal electrostatic deflection of ions obtained by the electrospray method at high flow rates of the liquid under analysis (200 to 300 microL/min), which ensures stable operation of the LC/IMS analytical setup without separating the liquid flow leaving the liquid chromatograph column.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurnin, I.V., Kayumov, A.A., Muradymov, M.Z. et al. Coupling of liquid chromatograph with ion-mobility spectrometer. Int. J. Ion Mobil. Spec. 16, 169–176 (2013). https://doi.org/10.1007/s12127-012-0110-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12127-012-0110-4

Keywords

Search

Navigation