Abstract
The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n = 40) and healthy control individuals (n = 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group (P < 0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group (P < 0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group (P < 0.05). These findings suggest that immune activity is altered in patients with TS.
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Acknowledgments
This work was supported by the Beijing Municipal Science & Technology Commission–Capital Clinical Characteristic Application Research (no. D10110705000000), the Beijing Natural Science Foundation (no. 7082045), and the Beijing An Ding Hospital Programs.
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Cheng, Yh., Zheng, Y., He, F. et al. Detection of Autoantibodies and Increased Concentrations of Interleukins in Plasma from Patients with Tourette's Syndrome. J Mol Neurosci 48, 219–224 (2012). https://doi.org/10.1007/s12031-012-9811-8
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DOI: https://doi.org/10.1007/s12031-012-9811-8