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Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress

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Abstract

Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given sodium arsenite (10 mg/kg body weight) in combination with arjunolic acid (10 mg/kg body weight) orally for two estrous cycles. Electrozymographic analysis explored that arjunolic acid co-treatment counteracted As3+-induced ROS production in uterine tissue by stimulating the activities of endogenous enzymatic antioxidants. Arjunolic acid was able to enhance the protection against mutagenic uterine DNA breakage, necrosis, and ovarian–uterine tissue damages in arsenicated rats by improving the ovarian steroidogenesis. The mechanisms might be coupled with the augmentation of antioxidant defense system, partly through the elimination of arsenic with the involvement of S-adenosyl methionine pool where circulating levels of vitamin B12, folic acid, and homocysteine play critical roles as evidenced from our present investigation.

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  1. Department of Biomedical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, 721102, India

    Moulima Maity, Hasina Perveen, Moumita Dash, Suryashis Jana, Shamima Khatun, Arindam Dey & Sandip Chattopadhyay

  2. Clinical Nutrition and Dietetics Division (Funded under UGC Innovative Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India

    Moulima Maity, Hasina Perveen, Moumita Dash, Suryashis Jana, Shamima Khatun, Arindam Dey & Sandip Chattopadhyay

  3. Department of Microbiology, Vidyasagar University, Midnapore, West Bengal, 721102, India

    Amit Kumar Mandal

  4. Chemical Biology Laboratory, Department of Sericulture, Raiganj University, Uttar Dinajpur, West Bengal, 733134, India

    Amit Kumar Mandal

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Maity, M., Perveen, H., Dash, M. et al. Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress. Biol Trace Elem Res 182, 78–90 (2018). https://doi.org/10.1007/s12011-017-1077-0

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