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L’apport des modèles expérimentaux dans l’étude de la douleur orofaciale chez l’humain

Contribution of experimental human models to the study of clinical orofacial pain

  • Article de Synthèse / Review Article
  • Published:
Douleur et Analgésie

Résumé

La modélisation de la douleur clinique orofaciale à travers le développement de modèles expérimentaux chez l’humain a connu, au fil des dernières décennies, un essor considérable. La diversité de ces modèles trouve son utilité dans l’étude des mécanismes impliqués dans l’apparition et dans la modulation des différents types de douleurs orofaciales observés en clinique. Cet article fait le point sur les modèles qui ont été développés, en soulignant leurs apports quant à la mise à jour de certains mécanismes tout en indiquant les avantages et les limites de ces modèles.

Abstract

We have witnessed over the past few decades tremendous efforts towards the development of human experimental models for the study of clinical orofacial pain. The different models are used to elucidate the mechanisms involved in the initiation and modulation of various types of orofacial pain. This article reviews the models that have been developed, stressing how they have contributed to the acquisition of new knowledge while pointing out their advantages and limitations.

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Références

  1. Ahlquist ML, Franzen OG (1994) Encoding of the subjective intensity of sharp dental pain. Endod Dent Traumatol 10:153–166

    Article  PubMed  CAS  Google Scholar 

  2. Ahlquist ML, Franzen OG (1994) Inflammation and dental pain in man. Endod Dent Traumatol 10:201–209

    Article  PubMed  CAS  Google Scholar 

  3. Alstergreen P, Ernberg M, Hajati AK, et al (2008) Glutamate-induced temporomandibular joint pain is partially mediated by NMDA receptors. Abstract no 169 at the IADR general session, Toronto, Canada

  4. Andersen H, Arendt-Nielsen L, Svensson P, et al (2008) Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans. Exp Brain Res 191:371–382

    Article  PubMed  Google Scholar 

  5. Arima T, Svensson P, Arendt-Nielsen L (2000) Capsaicin-induced muscle hyperalgesia in the exercised and non-exercised human masseter muscle. J Orofac Pain 14:213–223

    PubMed  CAS  Google Scholar 

  6. Arima T, Svensson P, Arendt-Nielsen L (1999) Experimental grinding in healthy subjects: a model for postexercise jaw muscle soreness? J Orofac Pain 13:104–114

    PubMed  CAS  Google Scholar 

  7. Ayesh EE, Jensen TS, Svensson P (2007) Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints. J Dent Res 86:1187–1192

    Article  PubMed  CAS  Google Scholar 

  8. Ayesh EE, Jensen TS, Svensson P (2007) Somatosensory function following painful repetitive electrical stimulation of the human temporomandibular joint and skin. Exp Brain Res 179:415–425

    Article  PubMed  CAS  Google Scholar 

  9. Baad-Hansen L, Jensen TS, Svensson P (2003) A human model of intraoral pain and heat hyperalgesia. J Orofac Pain 17:333–340

    PubMed  Google Scholar 

  10. Baad-Hansen L, Juhl GI, Jensen TS, et al (2006) Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain. Pain 129:46–54

    Article  PubMed  Google Scholar 

  11. Baad-Hansen L, List T, Jensen TS, Svensson P (2006) Increased pain sensitivity to intraoral capsaicin in patients with atypical odontalgia. J Orofac Pain 20:107–114

    PubMed  Google Scholar 

  12. Baad-Hansen L, List T, Kaube H, et al (2006) Blink reflexes in patients with atypical odontalgia and matched healthy controls. Exp Brain Res 172:498–506

    Article  PubMed  Google Scholar 

  13. Baad-Hansen L, Poulsen HF, Jensen HM, et al (2005) Lack of sex differences in modulation of experimental intraoral pain by diffuse noxious inhibitory controls (DNIC). Pain 116:359–365

    Article  PubMed  Google Scholar 

  14. Bentsen B, Wenzel A, Svensson P (2003) Comparison of the effect of video glasses and nitrous oxide analgesia on the perceived intensity of pain and unpleasantness evoked by dental scaling. Eur J Pain 7:49–53

    Article  PubMed  Google Scholar 

  15. Bird SE, Williams K, Kula K (2007) Preoperative acetaminophen vs ibuprofen for control of pain after orthodontic separator placement. Am J Orthod Dentofacial Orthop 132:504–510

    Article  PubMed  Google Scholar 

  16. Bowley JF, Gale EN (1987) Experimental masticatory muscle pain. J Dent Res 66:1765–1769

    PubMed  CAS  Google Scholar 

  17. Bradley RL, Ellis PE, Thomas P, et al (2007) A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofacial Orthop 132:511–517

    Article  PubMed  Google Scholar 

  18. Cairns BE, Svensson P, Wang K, et al (2003) Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol 90:2098–2105

    Article  PubMed  CAS  Google Scholar 

  19. Castrillon EE, Cairns BE, Ernberg M, et al (2008) Effect of peripheral NMDA receptor blockade with ketamine on chronic myofascial pain in temporomandibular disorder patients: a randomized, double blinded, placebo-controlled trial. J Orofac Pain 22:122–130

    PubMed  Google Scholar 

  20. Christensen LV (1971) Facial pain and internal pressure of masseter muscle in experimental bruxism in man. Arch Oral Biol 16:1021–1031

    Article  PubMed  CAS  Google Scholar 

  21. Claffey E, Reader A, Nusstein J, et al (2004) Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis. J Endod 30:568–571

    Article  PubMed  Google Scholar 

  22. Clark GT, Adler RC, Lee JJ (1991) Jaw pain and tenderness levels during and after repeated sustained maximum voluntary protrusion. Pain 45:17–22

    Article  PubMed  CAS  Google Scholar 

  23. Dao TT, Lund JP, Lavigne GJ (1994) Pain responses to experimental chewing in myofascial pain patients. J Dent Res 73:1163–1167

    PubMed  CAS  Google Scholar 

  24. Dionne RA (2001) Pharmacologic advances in orofacial pain: from molecules to medicine. J Dent Educ 65:1393–1403

    PubMed  CAS  Google Scholar 

  25. Edwards RR, Fillingim RB, Yamauchi S, et al (1999) Effects of gender and acute dental pain on thermal pain responses. Clin J Pain 15:233–237

    Article  PubMed  CAS  Google Scholar 

  26. Ernberg M, Alstergren P, Hajati AK, et al (2008) NMDA antagonist effects on TMJ pain induced by hypertonic saline. Abstract no 278 at the IADR general session, Toronto, Canada

  27. Gazerani P, Arendt-Nielsen L (2005) The impact of ethnic differences in response to capsaicin-induced trigeminal sensitization. Pain 117:223–229

    Article  PubMed  CAS  Google Scholar 

  28. Gazerani P, Kaeseler AO, Arendt-Nielsen L (2005) A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences Pain 118:155–163

    CAS  Google Scholar 

  29. Gazerani P, Staahl C, Drewes AM, et al (2006) The effects of botulinum toxin type A on capsaicin-evoked pain, flare and secondary hyperalgesia in an experimental human model of trigeminal sensitization. Pain 122:315–325

    Article  PubMed  CAS  Google Scholar 

  30. Gazerani P, Wang K, Cairns BE, et al (2006) Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women. Pain 124:338–348

    Article  PubMed  CAS  Google Scholar 

  31. Gobel H, Cordes P (1990) Circadian variation of pain sensitivity in pericranial musculature. Headache 30:418–422

    Article  PubMed  CAS  Google Scholar 

  32. Gordon SM, Dubner R, Dionne RA (1999) Antihyperalgesic effect of the N-methyl-D-aspartate receptor antagonist dextromethorphan in the oral surgery model. J Clin Pharmacol 39:139–146

    Article  PubMed  CAS  Google Scholar 

  33. Gracely RH (2005) Assessment and psychology of pain. In: McMahon SB, Koltzenburg M (eds) Wall and Melzack’s Textbook of Pain. Elsevier Churchill Livingstone 267–289

  34. Gracely RH, Dubner R, McGrath PA (1982) Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs. Anesth Analg 61:751–755

    Article  PubMed  CAS  Google Scholar 

  35. Jaberzadeh S, Svensson P, Nordstrom MA, et al (2003) Differential modulation of tremor and pulsatile control of human jaw and finger by experimental muscle pain. Exp Brain Res 150:520–524

    PubMed  Google Scholar 

  36. Jantsch HH, Kemppainen P, Ringler R, et al (2005) Cortical representation of experimental tooth pain in humans. Pain 118:390–399

    Article  PubMed  CAS  Google Scholar 

  37. Jeffcoat MK, Geurs NC, Magnusson I, et al (2001) Intrapocket anesthesia for scaling and root planing: results of a double blind multicenter trial using lidocaine prilocaine dental gel. J Periodontol 72:895–900

    Article  PubMed  CAS  Google Scholar 

  38. Jensen R, Olesen J (1996) Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia 16:175–182

    Article  PubMed  CAS  Google Scholar 

  39. Juhl GI, Jensen TS, Norholt SE, et al (2008) Central sensitization phenomena after third molar surgery: a quantitative sensory testing study. Eur J Pain 12:116–127

    Article  PubMed  Google Scholar 

  40. Juhl GI, Svensson P, Norholt SE, et al (2006) Long-lasting mechanical sensitization following third molar surgery. J Orofac Pain 20:59–73

    PubMed  Google Scholar 

  41. Kardelis AC, Meinberg TA, Sulte HR, et al (2002) Effect of narcotic pain reliever on pulp tests in women. J Endod 28:537–539

    Article  PubMed  Google Scholar 

  42. Klein T, Magerl W, Rolke R, et al (2005) Human surrogate models of neuropathic pain. Pain 115:227–233

    Article  PubMed  Google Scholar 

  43. Lee MH, Zarestsky HH, Ernst M, et al (1985) The analgesic effects of aspirin and placebo on experimentally induced tooth pulp pain. J Med 16:417–428

    PubMed  CAS  Google Scholar 

  44. Litkowski LJ, Christensen SE, Adamson DN, et al (2005) Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7,5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. Clin Ther 27:418–429

    Article  PubMed  CAS  Google Scholar 

  45. Lund JP, Donga R, Widmer CG, Stohler CS (1991) The pain-adaptation model: a discussion of the relationship between chronic musculoskeletal pain and motor activity. Can J Physiol Pharmacol 69:683–694

    PubMed  CAS  Google Scholar 

  46. May A, Kaube H, Büchel C, et al (1998) Experimental cranial pain elicited by capsaicin: a PET study. Pain 74:61–66

    Article  PubMed  CAS  Google Scholar 

  47. Mehlisch DR, Desjardins PJ, Daniels S, et al (2004) The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain. J Am Dent Assoc 135:1578–1590

    PubMed  CAS  Google Scholar 

  48. Michelotti A, Farella M, Martina R (1999) Sensory and motor changes of the human jaw muscles during induced orthodontic pain. Eur J Orthod 21:397–404

    Article  PubMed  CAS  Google Scholar 

  49. Nekoofar MH, Sadeghipanah M, Dehpour AR (2003) Evaluation of meloxicam (a cox-2 inhibitor) for management of postoperative endodontic pain: a double blind placebo-controlled study. J Endod 29:634–637

    Article  PubMed  Google Scholar 

  50. Ngom PI, Dubray C, Woda A (2001) A human oral capsaicin pain model to assess topical anesthetic-analgesic drugs. Neurosci Lett 316:149–152

    Article  PubMed  CAS  Google Scholar 

  51. Norholt SE (1998) Treatment of acute pain following removal of mandibular third molars. Use of the dental pain model in pharmacological research and development of a comparable animal model. Int J Oral Maxillofac Surg 27(Suppl 1):1–41

    Article  PubMed  Google Scholar 

  52. Phillips C, Essick G, Preisser JS, et al (2007) Sensory retraining after orthognathic surgery: effect on patients’ perception of altered sensation. J Oral Maxillofac Surg 65:1162–1173

    Article  PubMed  Google Scholar 

  53. Reid KI, Carlson C, Rayens MK, et al (1996) The influence of cutaneous tissue afferents on masticatory pain-pressure thresholds. J Orofac Pain 10:324–329

    PubMed  CAS  Google Scholar 

  54. Sadeghein A, Shahidi N, Dehpour AR (1999) A comparison of ketorolac tromethamine and acetaminophen codeine in the management of acute apical periodontitis. J Endod 25:257–259

    Article  PubMed  CAS  Google Scholar 

  55. Sessle BJ (2000) Acute and chronic craniofacial pain: brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates. Crit Rev Oral Biol Med 11:57–91

    Article  PubMed  CAS  Google Scholar 

  56. Sigurdsson A, Maixner W (1994) Effects of experimental and clinical noxious counterirritants on pain perception. Pain 57:265–275

    Article  PubMed  CAS  Google Scholar 

  57. Steen KH, Reeh PW (1993) Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin. Neurosci Lett 154:113–116

    Article  PubMed  CAS  Google Scholar 

  58. Stohler CS, Kowalski CJ (1999) Spatial and temporal summation of sensory and affective dimensions of deep somatic pain. Pain 79:165–173

    Article  PubMed  CAS  Google Scholar 

  59. Svensson P, Arendt-Nielsen L (1996) Effects of 5 days of repeated submaximal clenching on masticatory muscle pain and tenderness: an experimental study. J Orofac Pain 10:330–338

    PubMed  CAS  Google Scholar 

  60. Svensson P, Cairns BE, Wang K, et al (2003) Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain 104:241–247

    Article  PubMed  CAS  Google Scholar 

  61. Svensson P, Graven-Nielsen T (2001) Craniofacial muscle pain: review of mechanisms and clinical manifestations. J Orofac Pain 15:117–145

    PubMed  CAS  Google Scholar 

  62. Svensson P, Graven-Nielsen T, Arendt-Nielsen L (1998) Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles. Pain 74:93–100

    Article  PubMed  CAS  Google Scholar 

  63. Svensson P, Petersen JK, Svensson H (1994) Efficacy of a topical anesthetic on pain and unpleasantness during scaling of gingival pockets. Anesth Prog 41:35–39

    PubMed  CAS  Google Scholar 

  64. Svensson P, Wang K, Arendt-Nielsen L, et al (2008) Effects of NGF-induced muscle sensitization on proprioception and nociception. Exp Brain Res 189:1–10

    Article  PubMed  CAS  Google Scholar 

  65. Svensson P, Wang K, Sessle BJ, et al (2004) Associations between pain and neuromuscular activity in the human jaw and neck muscles. Pain 109:225–232

    Article  PubMed  Google Scholar 

  66. Uhle RA, Reader A, Nist R, et al (1997) Peripheral opioid analgesia in teeth with symptomatic inflamed pulps. Anesth Prog 44:90–95

    PubMed  CAS  Google Scholar 

  67. Vecchiet J, Cipollone F, Falasca K, et al (2003) Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 335:151–154

    Article  PubMed  CAS  Google Scholar 

  68. Wang K, Svensson P, Arendt-Nielsen L (2000) Effect of tonic muscle pain on short-latency jaw-stretch reflexes in humans. Pain 88:189–197

    Article  PubMed  CAS  Google Scholar 

  69. Wang K, Svensson P, Sessle BJ, et al (2008) Painful conditioning stimuli of trigeminal area evoke generalized DNIC response. Abstract no PT 125 at the IASP 12th World Congress on Pain, Glasgow, Scotland

  70. Woolf CJ (2004) Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 140:441–451

    PubMed  Google Scholar 

  71. Zhang X, Ashton-Miller JA, Stohler CS (1993) A closed-loop system for maintaining constant experimental muscle pain in man. IEEE Trans Biomed Eng 40:344–352

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Département de physiologie buccale, école de dentisterie, université d’Aarhus, 9, boulevard Vennelyst, DK-8000, Aarhus C, Danemark

    L. Baad-Hansen & P. Svensson

  2. Département de chirurgie maxillofaciale, hôpital universitaire d’Aarhus, Aarhus, Danemark

    P. Svensson

Authors
  1. L. Baad-Hansen
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  2. P. Svensson
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Correspondence to L. Baad-Hansen or P. Svensson.

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Baad-Hansen, L., Svensson, P. L’apport des modèles expérimentaux dans l’étude de la douleur orofaciale chez l’humain. Douleur analg 22, 121–129 (2009). https://doi.org/10.1007/s11724-009-0126-7

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  • DOI: https://doi.org/10.1007/s11724-009-0126-7

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