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Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

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Abstract

Background

Different studies have evaluated changes in adipo/cytokine levels after bariatric surgery and have given conflicting results. The adipo/cytokines, leptin and chemerin, and the orexigenic hormone, ghrelin, have been shown to play a role in the regulation of metabolism and appetite. The aims of our study were to test the levels of these molecules after bariatric surgery and to compare the results between Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy.

Methods

We analysed circulating levels of chemerin, ghrelin and leptin in 30 morbidly obese women (body mass index of >40 kg/m2). Subjects were studied at three time points: baseline (before the surgery started), and after 6 and 12 months.

Results

After surgery, chemerin (baseline, 95.03 ± 23.79; after 12 months, 76.80 ± 21.51; p = 0.034) and leptin levels (baseline, 248.17 ± 89.16; after 12 months, 63.85 ± 33.48; p < 0.001) were significantly lower than their baseline levels, whereas ghrelin was higher (baseline, 0.87 ± 0.38; after 12 months, 1.08 ± 0.31; p = 0.010). Fasting glucose, insulin and homeostasis model assessment of insulin resistance levels were markedly lower postoperatively. High-density lipoprotein levels moderately increased and triglyceride levels sharply decreased. There were no differences between the types of bariatric surgery in terms of weight reduction, general metabolic state or adipo/cytokine levels after surgery.

Conclusions

Our study demonstrates a marked decrease in fasting leptin and chemerin levels, and an increase in ghrelin levels, after bariatric surgery-induced weight loss, independently of the type of surgery performed. Further studies are needed on the interrelation between the changes in the circulating levels of these molecules and the efficacy of the bariatric surgery procedures to induce the beneficial metabolic changes and to sustain body weight loss.

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Acknowledgments

This study was supported by the Ministerio de Ciencia e Innovación of the government of Spain (grant number SAF 2008-02278 to CR), the Fondo de Investigación Sanitaria (grant number PS09/01778 to TA), by funds from Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR 2009 SGR 959 to CR), Grup de Recerca en Medicina Aplicada URV (2010PFR-URV-B2-14 to CR) and by the Fundación Biociencia.

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Authors and Affiliations

  1. Grup d’Estudi de Malalties Metabòliques Associades a Insulin Resistència (GEMMAIR), Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Tarragona, Spain

    Ximena Terra, Teresa Auguet, Esther Guiu-Jurado, Alba Berlanga, Josep Maria Orellana-Gavaldà, Carmen Aguilar & Cristóbal Richart

  2. Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Tarragona, Spain

    Teresa Auguet, Jose Antonio Porras, Jordi Llutart & Cristóbal Richart

  3. Servei de Cirurgia, Hospital Sant Joan de Reus, Tarragona, Spain

    Mercè Hernández, Fàtima Sabench & Daniel Del Castillo

  4. Servei Anatomia Patològica, Hospital Universitari Joan XXIII Tarragona, Tarragona, Spain

    Salomé Martinez

  5. Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, c/ Mallafré Guasch, 4, 43007, Tarragona, Catalonia, Spain

    Teresa Auguet

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  1. Ximena Terra
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  2. Teresa Auguet
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Corresponding author

Correspondence to Teresa Auguet.

Additional information

X. Terra and T. Auguet contributed equally to this work.

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Terra, X., Auguet, T., Guiu-Jurado, E. et al. Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy. OBES SURG 23, 1790–1798 (2013). https://doi.org/10.1007/s11695-013-1033-9

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