Skip to main content

Advertisement

Log in

Yield of Practice-Based Depression Screening In VA Primary Care Settings

  • Original Research
  • Published:
Journal of General Internal Medicine Aims and scope Submit manuscript

Abstract

Background

Many patients who should be treated for depression are missed without effective routine screening in primary care (PC) settings. Yearly depression screening by PC staff is mandated in the VA, yet little is known about the expected yield from such screening when administered on a practice-wide basis.

Objective

We characterized the yield of practice-based screening in diverse PC settings, as well as the care needs of those assessed as having depression.

Design

Baseline enrollees in a group randomized trial of implementation of collaborative care for depression.

Participants

Randomly sampled patients with a scheduled PC appointment in ten VA primary care clinics spanning five states.

Measurements

PHQ-2 screening followed by the full PHQ-9 for screen positives, with standardized sociodemographic and health status questions.

Results

Practice-based screening of 10,929 patients yielded 20.1% positive screens, 60% of whom were assessed as having probable major depression based on the PHQ-9 (11.8% of all screens) (n = 1,313). In total, 761 patients with probable major depression completed the baseline assessment. Comorbid mental illnesses (e.g., anxiety, PTSD) were highly prevalent. Medical comorbidities were substantial, including chronic lung disease, pneumonia, diabetes, heart attack, heart failure, cancer and stroke. Nearly one-third of the depressed PC patients reported recent suicidal ideation (based on the PHQ-9). Sexual dysfunction was also common (73.3%), being both longstanding (95.1% with onset >6 months) and frequently undiscussed and untreated (46.7% discussed with any health care provider in past 6 months).

Conclusions

Practice-wide survey-based depression screening yielded more than twice the positive-screen rate demonstrated through chart-based VA performance measures. The substantial level of comorbid physical and mental illness among PC patients precludes solo management by either PC or mental health (MH) specialists. PC practice- and provider-level guideline adherence is problematic without systems-level solutions supporting adequate MH assessment, PC treatment and, when needed, appropriate MH referral.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

Similar content being viewed by others

References

  1. Lowe B, Unutzer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004;42:1194–1201.

    Article  PubMed  Google Scholar 

  2. Katon WJ, Unutzer J, Simon G. Treatment of depression in primary care: Where we are, where we can go. Med Care. 2004;42(12):1153–7.

    Article  PubMed  Google Scholar 

  3. Perez-Stable E, Mirana J, Munoz RF, Ying Y-W. Depression in medical outpatients: Under-recognition and misdiagnosis. Arch Intern Med. 1990;150:1083–8.

    Article  PubMed  CAS  Google Scholar 

  4. Young AS, Klap R, Sherbourne CD, Wells KB. The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psychiatry. 2001;58(1):55–61.

    Article  PubMed  CAS  Google Scholar 

  5. Olfson M, Marcus SC, Druss B, Elinson L, Tanielian T, Pincus HA. National trends in the outpatient treatment of depression. JAMA. 2002;287(2):203–9.

    Article  PubMed  Google Scholar 

  6. Egede LE. Failure to recognize depression in primary care: Issues and challenges. J Gen Intern Med. 2007;22:701–3.

    Article  PubMed  Google Scholar 

  7. Edlund MJ, Unutzer J, Wells KB. Clinician screening and treatment of alcohol, drug and mental problems in primary care. Med Care. 2004;42(12):1158–66.

    Article  PubMed  Google Scholar 

  8. Pignone MP, Gaynes BN, Rushton JL, et al. Screening for depression in adults: A summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2002;136:765–76.

    PubMed  Google Scholar 

  9. Fickel JJ, Yano EM, Parker LE, Rubenstein LV. Clinic-level process of care for depression in primary care settings. Adm Policy Ment Health. 2009;36:144–58.

    Article  PubMed  Google Scholar 

  10. Campbell DG, Felker BL, Liu C-F, et al. Prevalence of depression-PTSD co-morbidity: Implications for clinical practice guidelines and primary care-based interventions. J Gen Intern Med. 2007;22(6):711–8.

    Article  PubMed  Google Scholar 

  11. Chaney EF, Rubenstein LV, Liu C-F, Yano EM, Bolkan C, Lee ML, Simon BF, Lanto AB, Felker B, Uman J. Implementing collaborative care for depression treatment in primary care: A cluster randomized evaluation of a quality improvement practice redesign. Implement Sci. 2011:[in press].

  12. Bonner L, Felker B, Chaney E, et al. Suicide risk response: Enhancing patient safety through development of effective institutional policies. In K Henriksen, JB Battles, E Marks & DI Lewin (Eds), Advances in Patient Safety: From Research to Implementation. Vol. 3, 507–519, 2005.

  13. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire. JAMA. 1999;282:1737–44.

    Article  PubMed  CAS  Google Scholar 

  14. Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: Validity of a two-item depression screener. Med Care. 2003;41(11):1284–92.

    Article  PubMed  Google Scholar 

  15. Li C, Friedman B, Conwell Y, Fiscella K. Validity of the Patient Health Questionnaire 2 (PHQ-2) in identifying major depression in older people. J Am Geriatrics Soc. 2007;55(4):596–602.

    Article  Google Scholar 

  16. Corson K, Gerrity MS, Dobscha SK. Screening for depression and suicidality in a VA primary care setting: 2 items are better than 1 item. Am J Manag Care. 2004;10(11 Pt 2):839–45.

    PubMed  Google Scholar 

  17. National Institute of Mental Health. Depression. Available at http://www.nimh.nih.gov/health/publications/depression/complete-index.shtml. Accessed June 20, 2011.

  18. Henkel V, Mergl R, Kohnen R, Maier W, Moller H-J, Hegerl U. Identifying depression in primary care: A comparison of different methods in a prospective cohort study. BMJ. 2003;326:200–1.

    Article  PubMed  Google Scholar 

  19. Pinto-Meza A, Serrano-Blanco A, Penarrubia MT, Blanco E, Haro JM. Assessing depression in primary care with the PHQ-9: Can it be carried out over the telephone? J Gen Intern Med. 2005;20:738–42.

    Article  PubMed  Google Scholar 

  20. Ware JE, Kosinski M, Bayliss MS, McHorney CA, Rogers WH, Raczek A. Comparison of methods for scoring and statistical analysis of SF-36 health profile and summary measures: Summary of results from the Medical Outcomes Study. Med Care. 1995;33:264–79.

    Article  Google Scholar 

  21. Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.

    Article  PubMed  Google Scholar 

  22. Fan VS, Au D, Heagerty P, Deyo RA, McDonell MB, Fihn SD. Validation of case-mix measures derived from self-reports of diagnosis and health. J Clin Epidemiol. 2002;55(4):371–80.

    Article  PubMed  Google Scholar 

  23. Prins A, Ouimette P, Kimerling R, et al. The primary care PTSD screen (PC-PTSD): Development and operating characteristics. Prim Care Psychiatry. 2003;9:9–14.

    Article  Google Scholar 

  24. Das AK, Olfson M, Gameroff MJ, et al. Screening for bipolar disorder in a primary care practice. JAMA. 2005;293:956–63.

    Article  PubMed  CAS  Google Scholar 

  25. Dawson DA, Grant BF, Stinson FS, Zhou Y. Effectiveness of the derived Alcohol Use Disorders Identification Test (AUDIT-C) in screening for alcohol use disorders and risk drinking in the US general population. Alcohol Clin Exp Res. 2005;29(5):844–54.

    Article  PubMed  Google Scholar 

  26. Bradley KA, Bush KR, Epler AJ, et al. Two brief alcohol-screening tests from the Alcohol Use Disorders Identification Test (AUDIT), validation in a female Veterans Affairs patient population. Arch Intern Med. 2003;163(7):821–29.

    Article  PubMed  Google Scholar 

  27. Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.

    Article  PubMed  CAS  Google Scholar 

  28. Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095–105.

    Article  PubMed  Google Scholar 

  29. Rogers WH, Kazis LE, Miller DR, et al. Comparing the health status of VA and non-VA ambulatory patients: the veterans’ health and medical outcomes studies. J Ambul Care Manage. 2004;27(3):249–62.

    PubMed  Google Scholar 

  30. Katon W. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Bio Psychiatry. 2003;54:216–26.

    Article  Google Scholar 

  31. Kirchner JE, Curran GM, Aikens J. Detecting depression in VA primary care clinics. Psych Services. 2004;55(4):350.

    Article  Google Scholar 

  32. Desai MM, Rosenheck RA, Craig TJ. Case-finding for depression among medical outpatients in the Veterans Health Administration. Med Care. 2006;44(2):175–81.

    Article  PubMed  Google Scholar 

  33. Kirkcaldy RD, Tynes LL. Depression screening in a VA primary care clinic. Psych Services. 2006;57(12):1694–6.

    Article  Google Scholar 

  34. Oslin DW, Ross J, Sayers S, Murphy J, Kane V, Katz IR. Screening, assessment and management of depression in VA primary care clinics: The Behavioral Health Laboratory. J Gen Intern Med. 2006;21(1):46–50.

    Article  PubMed  Google Scholar 

  35. The Management of Major Depressive Disorder Working Group. Veterans Health Administration/Department of Defense clinical practice guidelines for the management of major depressive disorder in adults. Version 2.0, February 2000, Washington DC.

  36. Angst J, Angst F, Stassen HH. Suicide risk in patients with major depressive disorder. J Clin Psych. 1999;60(Suppl 2):57–62.

    Google Scholar 

  37. Foster T, Gillespie K, McClelland R, Patterson C. Risk factors for suicide independent of DSM-III-R Axis I disorder. Brit J Psychiatry. 1999;175:175–9.

    Article  CAS  Google Scholar 

  38. Uebelacker LA, German NM, Gaudiano BA, Miller IW. Patient health questionnaire depression scale as a suicide screening instrument in depression primary care patients: A cross-sectional study. Prim Care Companion CNS Disord. 2011;13(1).

  39. Schulberg HC, Lee PW, Bruce ML, et al. Suicidal ideation and risk levels among primary care patients with uncomplicated depression. Ann Fam Med. 2005;3(6):523–528.

    Article  PubMed  Google Scholar 

  40. Veterans Health Administration. Suicide prevention. Available at www.mentalhealth.va.gov/suicide_prevention/index.asp, accessed June 22, 2011.

  41. Nutting PA, Dickinson LM, Rubenstein LV, Keeley RD, Smith JL, Elliott CE. Improving detection of suicidal ideation among depressed patients in primary care. Ann Fam Med. 2005;3(6):529–36.

    Article  PubMed  Google Scholar 

  42. Trude S, Stoddard JJ. Referral gridlock: Primary care physicians and mental health services. J Gen Intern Med. 2003;18:442–9.

    Article  PubMed  Google Scholar 

  43. Rubenstein LV, Parker LE, Meredith LS, et al. Understanding team-based quality improvement for depression in primary care. Health Serv Res. 2002;37(4):1009–29.

    Article  PubMed  Google Scholar 

  44. Gilbody S, Whitty P, Grimshaw J, Thomas R. Educational and organizational interventions to improve the management of depression in primary care: A systematic review. JAMA. 2003;289(23):3145–51.

    Article  PubMed  Google Scholar 

  45. Katon W, Schulberg H. Epidemiology of depression in primary care. Gen Hosp Psychiatry. 1992;14:237–47.

    Article  PubMed  CAS  Google Scholar 

  46. Felker BL, Hedrick SC, Chaney EF, et al. Identifying depressed patients with a high risk of comorbid anxiety in primary care. Primary Care Companion J Clin Psychiatry. 2003;5:104–10.

    Article  PubMed  Google Scholar 

  47. Weilburg JB, Stafford RS, O’Leary KM, Meigs JB, Finkelstein SN. Costs of antidepressant medications associated with inadequate treatment. Am J Manag Care. 2004;10(6):357–65.

    PubMed  Google Scholar 

  48. Frank RG, McGuire TG, Normand ST, Goldman HH. The value of mental health care at the system level: The case of treating depression. Health Affairs. 1999;18(5):71–88.

    Article  PubMed  CAS  Google Scholar 

  49. Rost K, Pyne JM, Dickinson LM, LoSasso AT. Cost-effectiveness of enhancing primary care depression management on an ongoing basis. Ann Fam Med. 2005;3(1):7–14.

    Article  PubMed  Google Scholar 

  50. Klinkman MS. The role of algorithms in the detection and treatment of depression in primary care. J Clin Psychiatry. 2003;64(Suppl 2):19–23.

    PubMed  Google Scholar 

  51. Zlotnick C, Rodriquez BF, Wiesberg RB, et al. Chronicity in posttraumatic stress disorder and predictors of the course of posttraumatic stress disorder among primary care patients. J Nerv Ment Dis. 2004;192:153–9.

    Article  PubMed  Google Scholar 

  52. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51:8–19.

    Article  PubMed  CAS  Google Scholar 

  53. Glied S. Too little time? The recognition and treatment of mental health problems in primary care. Health Serv Res. 1998;33(4):891–910.

    PubMed  CAS  Google Scholar 

  54. Robbins JM, Kirmayer LJ, Cathebras P, Yaffe MJ, Dworkind M. Physician characteristics and the recognition of depression and anxiety in primary care. Med Care. 1994;32(8):795–812.

    Article  PubMed  CAS  Google Scholar 

  55. Wittchen HU, Kessler RC, Beesdo K, Krause P, Hofler M, Hoyer J. Generalized anxiety and depression in primary care: Prevalence, recognition and management. J Clin Psychiatry. 2002;63:24–34.

    PubMed  Google Scholar 

  56. Lecrubier Y. Posttraumatic stress disorder in primary care: A hidden diagnosis. J Clin Psychiatry. 2004;65(suppl 1):49–54.

    PubMed  Google Scholar 

  57. Ramaswamy S, Madaan V, Qadri F, et al. A primary care perspective on posttraumatic stress disorder for the Department of Veterans Affairs. Prim Care Companion J Clin Psychiatry. 2005;7(4):180–7.

    Article  PubMed  Google Scholar 

  58. Zeiss AM, Karlin BE. Integrating mental health and primary care services in the Department of Veterans Affairs health care system. J Clin Psychol Med Settings. 2008;15:73–8.

    Article  PubMed  Google Scholar 

  59. Katon WJ, Von Korff M, Lin E, et al. Collaborative management to achieve treatment guidelines: Impact on depression in primary care. JAMA. 1995;273(13):1026–31.

    Article  PubMed  CAS  Google Scholar 

  60. Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127(12):1097–1102.

    Google Scholar 

  61. Post EP, Van Stone WW. The Veterans Health Administration’s primary care-mental health integration initiative. N C Med J. 2008;69(1):49–52.

    PubMed  Google Scholar 

  62. Neumeyer-Gromen A, Lampert T, Soz D, Stark K, Kallischnigg G, Math D. Disease management programs for depression: A systematic review and meta-analysis of randomized controlled trials. Med Care. 2004;42:1211–21.

    Article  PubMed  Google Scholar 

  63. Rost K, Zhang M, Fortney J, Smith J, Coyne J, Smith GR. Persistently poor outcomes of undetected major depression in primary care. Gen Hosp Psych. 1998;20:12–20.

    Article  CAS  Google Scholar 

  64. Wells KB, Hayes RD, Burnam A, et al. Detection of depressive disorder for patients receiving prepaid or fee-for-service care: Results from the Medical Outcomes Study. JAMA. 1989;262:3298–303.

    Article  PubMed  CAS  Google Scholar 

  65. Bradley KA, Maynard C, Kivlahan DR, et al. The relationship between alcohol screening questionnaires and mortality among male VA outpatients. J Stud Alcohol. 2001;62:826–33.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This project was funded by the Department of Veterans Affairs (VA) Health Services Research and Development (HSR&D) Service and the Quality Enhancement Research Initiative (QUERI) (Project #MHI 99–375 and MNT 01–027). The manuscript reflects baseline data from a group randomized trial (Trial Registration No. NCT00105820). Dr. Yano is funded under a VA HSR&D Research Career Scientist award (Project #05–195). Dr. Campbell was funded by a VA Office of Academic Affiliations (OAA) Associated Health Postdoctoral Fellowship Program at the Northwest Center for Outcomes Research at the time the study was conducted; he is now Assistant Professor at the University of Montana.

We would like to acknowledge key intervention team members, including Susan Vivell, PhD, MBA, and Brad Felker, MD, as well as project support staff, Carol Simons, Laura Rabuck, MPA, and Debbie Mittman, MPA. Special recognition goes to the frontline efforts of the original network-level depression care managers, including Karen Vollen, RN, Barbara Revay, RN, and Bill Raney, as well as the site principal investigators at participating facilities.

An earlier version of this work was presented as a poster at the national meeting of the Society for General Internal Medicine (SGIM), New Orleans, LA, May 13, 2005.

The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or the United States government.

Conflict of Interest

None disclosed.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Elizabeth M. Yano PhD, MSPH.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yano, E.M., Chaney, E.F., Campbell, D.G. et al. Yield of Practice-Based Depression Screening In VA Primary Care Settings. J GEN INTERN MED 27, 331–338 (2012). https://doi.org/10.1007/s11606-011-1904-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11606-011-1904-5

Keywords

Navigation