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First-pass perfusion of non-small-cell lung cancer (NSCLC) with 64-detector-row CT: a study of technique repeatability and intra- and interobserver variability

  • Chest Radiology
  • Published:
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Abstract

Purpose

This study was done to prospectively assess the repeatability and intra- and interobserver variability of first-pass perfusion with 64-detector-row computed tomography (CT) in non-small-cell lung cancer (NSCLC) with a maximum diameter of up to 8 cm.

Materials and methods

Twelve patients with NSCLC underwent 64-detector-row first-pass CT perfusion (CTP) of the whole tumour. Two different techniques were used according to lesion size (cine mode; sequential mode). After 24 h, each study was repeated to assess repeatability. Lesion blood volume (BV), blood flow (BF), mean transit time (MTT) and peak enhancement intensity (PEI) were automatically calculated by two chest radiologists in two different reading sessions. Intra- and interobserver variability was also assessed.

Results

The first-pass CTP technique was repeatable and precise with within-subject coefficient of variation (WCV) of 9.3, 16.4, 11.2 and 14.9 %, respectively, for BV, BF, MTT and PEI. High intra- and interobserver agreement was demonstrated for each perfusion parameter, with Cronbach’s α coefficients and intraclass correlation coefficients ranging from 0.99 to 1. Precision of measurements was slightly better for intraobserver analysis with WCV ranging between 1.05 and 3.03 %.

Conclusions

Non-small-cell lung cancer first-pass perfusion performed with 64-detector-row CT showed good repeatability and high intra- and interobserver agreement for all perfusion parameters and may be considered a reliable and robust tool for assessing tumour vascularisation.

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Conflict of interest

A. R. Larici, L. Calandriello, M. Amato, R. Silvestri, A. del Ciello, F. Molinari, C. de Waure, M. L. Vita, G. Carnassale, and L. Bonomo declare no conflict of interest.

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Authors and Affiliations

  1. Department of Bioimaging and Radiological Sciences, Catholic University, “A. Gemelli” Hospital, Largo A. Gemelli 8, 00168, Rome, Italy

    Anna Rita Larici, Lucio Calandriello, Michele Amato, Roberta Silvestri, Annemilia del Ciello, Francesco Molinari & Lorenzo Bonomo

  2. Institute of Hygiene, Catholic University, “A. Gemelli” Hospital, Largo A. Gemelli 8, 00168, Rome, Italy

    Chiara de Waure

  3. Department of Surgical Sciences, Catholic University, “A. Gemelli” Hospital, Largo A. Gemelli 8, 00168, Rome, Italy

    Maria Letizia Vita & Giulia Carnassale

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  1. Anna Rita Larici
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  2. Lucio Calandriello
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  3. Michele Amato
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  4. Roberta Silvestri
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  5. Annemilia del Ciello
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  9. Giulia Carnassale
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  10. Lorenzo Bonomo
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Correspondence to Anna Rita Larici.

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Larici, A.R., Calandriello, L., Amato, M. et al. First-pass perfusion of non-small-cell lung cancer (NSCLC) with 64-detector-row CT: a study of technique repeatability and intra- and interobserver variability. Radiol med 119, 4–12 (2014). https://doi.org/10.1007/s11547-013-0300-0

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  • DOI: https://doi.org/10.1007/s11547-013-0300-0

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