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Cortical inhibition is reduced following short-term training in young and older adults

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Abstract

The purpose of this study was to investigate age-related differences in short-term training adaptations in cortical excitability and inhibition. Thirty young (21.9 ± 3.1 years) and 30 older (72.9 ± 4.6 years) individuals participated in the study. Each participant was randomly assigned to a control (n = 30) or a resistance training (n = 30) group, with equal numbers of young and older subjects in each group. Participants completed 2 days of testing, separated by 2 weeks during which time the training group participated in resistance training of the ankle dorsiflexor muscles three times per week. During each testing session, transcranial magnetic stimulation was used to generate motor evoked potentials (MEPs) and silent periods in the tibialis anterior. Hoffmann reflexes (H-reflexes) and compound muscle action potentials (M-waves) were also evoked via electrical stimulation of the peroneal nerve. At baseline, young subjects had higher maximum voluntary contraction (MVC) force (p = 0.002), larger M-wave amplitude (p < 0.001), and longer duration silent periods (p = 0.01) than older individuals, with no differences in the maximal amplitude of the MEP (p = 0.23) or H-reflex (p = 0.57). In the trained group, MVC increased in both young (17.4 %) and older (19.8 %) participants (p < 0.001), and the duration of the silent period decreased by ~15 and 12 ms, respectively (p < 0.001). Training did not significantly impact MEP (p = 0.69) or H-reflex amplitudes (p = 0.38). There were no significant changes in any measures in the control group (p ≥ 0.19) across the two testing sessions. These results indicate that a reduction in cortical inhibition may be an important neural adaptation in response to training in both young and older adults.

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Acknowledgments

This work was partially funded by a grant from the American College of Sports Medicine (AD Christie).

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Authors and Affiliations

  1. Department of Kinesiology, University of Massachusetts, Amherst, MA, 01003, USA

    Anita Christie & Gary Kamen

  2. Department of Human Physiology, University of Oregon, Eugene, OR, 97403, USA

    Anita Christie

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  1. Anita Christie
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  2. Gary Kamen
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Correspondence to Anita Christie.

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Christie, A., Kamen, G. Cortical inhibition is reduced following short-term training in young and older adults. AGE 36, 749–758 (2014). https://doi.org/10.1007/s11357-013-9577-0

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