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Changes in lipid distribution during aging and its modulation by calorie restriction

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Abstract

Adipogenesis and ectopic lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic diseases with age. However, at present, information on the age-related molecular changes in lipid redistribution patterns and their potential nutritional interventions is sparse. We investigated the mechanism underlying age-related lipid redistribution and its modulation using 5-, 17-, and 24-month-old male Fischer 344 rats fed ad libitum (AL) or a 3-week-long CR (40% less than AL) diet. Results revealed that the activities of adipogenic transcription factors were decreased in the white adipose tissue (WAT) of aged AL rats. In contrast, the skeletal muscle of aged AL rats showed increased fat accumulation through decreased carnitine palmitoyltransferase-1 activity, which was blunted by short-term CR. This study suggests an age-related shift in lipid distribution by reducing the adipogenesis of WAT while increasing intramyocellular lipid accumulation, and that CR can modulate age-related adipogenesis and ectopic lipid accumulation.

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Acknowledgments

This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. 2007-00376). We are thankful to the Aging Tissue Bank for supplying irradiated tissue.

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Authors and Affiliations

  1. Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung-gu, Busan, 609-735, Korea

    Ji Young Kim, Dae Hyun Kim, Jaehun Choi, Byung Pal Yu & Hae Young Chung

  2. Longevity Life Science and Technology Institutes, College of Pharmacy, Pusan National University, Busan, 609-735, South Korea

    Ji Young Kim, Byung Pal Yu & Hae Young Chung

  3. Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, South Korea

    Jin-Kyu Park & Kyu-Shik Jeong

  4. Department of Aging and Geriatrics, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, 32610-0267, USA

    Christiaan Leeuwenburgh & Hae Young Chung

  5. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229-3900, USA

    Byung Pal Yu

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  1. Ji Young Kim
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Kim, J.Y., Kim, D.H., Choi, J. et al. Changes in lipid distribution during aging and its modulation by calorie restriction. AGE 31, 127–142 (2009). https://doi.org/10.1007/s11357-009-9089-0

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