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Biological effects of citalopram in a suspended sediment-water system on Daphnia magna

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Abstract

Suspended sediment (SPS) plays an important role in the aquatic ecosystems. Selective serotonin uptake inhibitors (SSRIs) are commonly used antidepressants and are frequently detected in aquatic environments. However, the biological effects of SSRIs in the presence of SPS are not well understood. To fill this gap, an SPS-water system was constructed to investigate the effects of citalopram (CIT) on Daphnia magna in the presence of SPS with different concentrations (0.1, 0.5, 1 g l−1) and organic carbon contents (0.5, 1, 1.5, 2%). A dialysis bag was applied in the exposure system to control the same dissolved concentration of CIT and prevent SPS from entering into the bag. The dissolved CIT concentration obviously decreased in the SPS-water system during the exposure period. The presence of SPS significantly increased the immobilization of D. magna, and the immobilization rates were positively correlated with the SPS concentration and negatively correlated with the organic carbon content in SPS. For a single exposure, CIT significantly increased superoxide dismutase (SOD) activity and inhibited acetylcholinesterase (AChE) activity in D. magna, while SPS itself did not change the SOD and AChE activities. In the SPS-water system, SOD activity was significantly suppressed, indicating that the SPS-CIT combination could result in oxidative damage. However, SPS did not enhance the neurotoxicity of D. magna that was induced by CIT. These results suggest that SPS exerts a vital role on the biological effects of CIT and the contaminants sorbed on SPS should be taken into consideration.

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Acknowledgements

This study was supported by the National Science Funds for Creative Research Groups of China (Grant No. 51421006), the Yarlung Zangbo Scholars of XiZang Agricultural and Animal Husbandry College (Grant No. 2015XYA01), the National Natural Science Foundation of China (Grant No. 516030611), the Fundamental Research Funds for the Central Universities (Grant No. 2016B43914), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. Key Laboratory for Integrated Regulation and Resources Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China

    Haohan Yang, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Binni Ma & Huike Dong

  2. College of Hydraulic and Civil Engineering, XiZang Agricultural and Animal Husbandry College, Linzhi, 860000, China

    Guanghua Lu

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  1. Haohan Yang
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  2. Guanghua Lu
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Correspondence to Guanghua Lu.

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Yang, H., Lu, G., Yan, Z. et al. Biological effects of citalopram in a suspended sediment-water system on Daphnia magna . Environ Sci Pollut Res 24, 21180–21190 (2017). https://doi.org/10.1007/s11356-017-9763-1

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